Letrozole and Sequential Clomiphene to Improve the Outcome of Embryo Transfer
NCT ID: NCT02775877
Last Updated: 2017-06-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
100 participants
INTERVENTIONAL
2016-05-31
2020-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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letrozole and clomiphene
Letrozole 5 mg tablet orally from 3-7 day of once a day menstrual cycle and clomiphene100 mg tablet orally once a day from 11-15 day of menstrual cycle.
Letrozole
clomiphene
Letrozole and human menopausal gonadotropin (HMG)
Letrozole 5 mg tablet orally from 3-7 day of once a day menstrual cycle and HMG 75u once a day by intramuscular injection from 11-15day of menstrual cycle
Letrozole
HMG
Interventions
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Letrozole
clomiphene
HMG
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* With infectious diseases or endocrine diseases
* Who refuse to participate in the experiment
20 Years
38 Years
FEMALE
Yes
Sponsors
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Navy General Hospital, Beijing
OTHER
Responsible Party
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Yunhai Chuai
Department of Obstetrics and Gynecology, Navy General Hospital, Beijing
Principal Investigators
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Aiming Wang, Dr
Role: PRINCIPAL_INVESTIGATOR
Navy General Hospital, Beijing
Locations
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Department of Obstetrics and Gynecology, Navy General Hospital.
Beijing, Beijing Municipality, China
Countries
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Central Contacts
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Facility Contacts
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References
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Kamath MS, George K. Letrozole or clomiphene citrate as first line for anovulatory infertility: a debate. Reprod Biol Endocrinol. 2011 Jun 21;9:86. doi: 10.1186/1477-7827-9-86.
Legro RS, Kunselman AR, Brzyski RG, Casson PR, Diamond MP, Schlaff WD, Christman GM, Coutifaris C, Taylor HS, Eisenberg E, Santoro N, Zhang H; NICHD Reproductive Medicine Network. The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome. Contemp Clin Trials. 2012 May;33(3):470-81. doi: 10.1016/j.cct.2011.12.005. Epub 2012 Jan 13.
Hajishafiha M, Dehghan M, Kiarang N, Sadegh-Asadi N, Shayegh SN, Ghasemi-Rad M. Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome. Drug Des Devel Ther. 2013 Dec 3;7:1427-31. doi: 10.2147/DDDT.S50972. eCollection 2013.
Legro RS, Zhang H; Eunice Kennedy Shriver NICHD Reproductive Medicine Network. Letrozole or clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med. 2014 Oct 9;371(15):1463-4. doi: 10.1056/NEJMc1409550. No abstract available.
Other Identifiers
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HL2015
Identifier Type: -
Identifier Source: org_study_id
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