Reversibility of Minimal Hepatic Encephalopathy Following Liver Transplantation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-06-30

Brief Summary

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This study included 20 patients listed for liver transplantation in addition to 20 age- and sex- matched controls. Neurological, psychiatric, laboratory and radiological examinations were performed for both patients and controls before and 6 months after liver transplantation. Assessment of cognitive functions by Trail Making Test A (TMT A), TMT B, Digit Symbol Test (DST), and Serial Dotting Test (SDT) was done before and after liver transplantation.

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Detailed Description

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Conditions

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Minimal Hepatic Encephalopathy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Patient Group

Twenty right handed patients with biopsy-proven liver cirrhosis listed for liver transplantation.

Liver transplantation

Intervention Type PROCEDURE

Control Group

Twenty age-matched healthy persons. They were similar to the patient group in respect to the number of education years, sex, and handedness.

No interventions assigned to this group

Interventions

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Liver transplantation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Right handed patients with biopsy-proven liver cirrhosis listed for liver transplantation

Exclusion Criteria

* Overt hepatic encephalopathy.
* Significant cortical atrophy or other structural brain changes revealed by conventional neuro-imaging.
* Regular use of psychotropic drugs, such as benzodiazepines.
* Known major psychiatric disorder.
* Less than 6 months of complete alcohol abstinence.
* Post-transplant toxic levels of immunosuppressive drugs.
* Patients unable to perform the tests (Illiterate or upper limb motor handicaps).

Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes