Exploring the Mechanisms of Resistance of Stem Cells Myeloproliferative Opposite of Tyrosine Kinase Inhibitors in 3d Model Niche Endosteal
NCT ID: NCT02766153
Last Updated: 2024-02-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
200 participants
OBSERVATIONAL
2016-05-31
2020-12-31
Brief Summary
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Work in the group Bipoa "Bio Engineering and Pathophysiology Osteo-Articular" helped develop a 3D model of ex vivo bone formation, which can mimic the endosteal niche. the goal is to apply this model to the SMP of hematopoiesis by referring to normal hematopoiesis. it will be tested the hypothesis that the endosteal ex vivo recess of the 3D modeling allows to highlight a special interaction can promote the persistence of the leukemia stem cell despite the use of effective therapies.
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Detailed Description
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Conditions
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Study Design
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OTHER
PROSPECTIVE
Study Groups
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patients
No interventions assigned to this group
healthy volunteers
intrafamily marrow donors
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
18 Years
ALL
Yes
Sponsors
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Centre National de la Recherche Scientifique, France
OTHER
Centre Hospitalier Universitaire de Nice
OTHER
Responsible Party
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Locations
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CHU de Nice
Nice, , France
Countries
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Other Identifiers
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14-PP-02
Identifier Type: -
Identifier Source: org_study_id
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