Establishment of a Sensitive System for Analysis of Child-bearing Women Vaginal Microbiota
NCT ID: NCT02763696
Last Updated: 2017-03-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
50 participants
OBSERVATIONAL
2016-05-10
2018-12-31
Brief Summary
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The vaginal microbiota of child-bearing women of age is dominated by Lactobacillus species, including major four species: Lactobacillus crispatus, Lactobacillus jensenii, Lactobacillus gasseri and Lactobacillus iners, followed by obligate anaerobes such as Gardnerella vaginalis, Atopobium vaginae, Mobiluncus curtisii, and Prevotella .
Currently, There are almost 99% bacteria can not to be found with bacterial culture. Based on microscopy and conventional culture method to obtain vaginal microflora information have a variety of deviation. For this reason, The in-depth study of complex vaginal flora and the correct understanding of disease faces a serious obstacle. With the development of High-throughput sequencing technology， metagenomics can get all the composition and distribution of microorganisms from the sample which traditional knowledge may not be with microorganism culture method. Therefore, Re-evaluation of existing microflora diagnostic criteria for clinical diagnosis of the disease is necessary.
In this study, the investigators use high-throughput sequencing technology to detect women of childbearing age vaginal microflora of metagenomic distribution. Including bacteria, fungi, viruses, protozoa, and other microorganisms. Based on the study results of metagenomic, the investigators want to re-cognition the"normal flora"of women of childbearing age ,and develop vaginal microflora microscopic evaluation of the integrity of the reference standard.
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Detailed Description
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Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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normal women
Composition of Viginal flora of Child-Bearing women in normal woman
Composition of Viginal flora of Child-Bearing women
Use high-throughput sequencing technology to exam Composition of Viginal flora of Child-Bearing women in different menstrual cycle and type of Vaginitis
vaginitis women
Women of childbearing age with vaginitis
Composition of Viginal flora of Child-Bearing women
Use high-throughput sequencing technology to exam Composition of Viginal flora of Child-Bearing women in different menstrual cycle and type of Vaginitis
Interventions
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Composition of Viginal flora of Child-Bearing women
Use high-throughput sequencing technology to exam Composition of Viginal flora of Child-Bearing women in different menstrual cycle and type of Vaginitis
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Lactating women
* Using antibiotics or vaginal topical application of antibiotics over a month
* Have sexual activity in 3 days
19 Years
45 Years
FEMALE
Yes
Sponsors
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First Affiliated Hospital Xi'an Jiaotong University
OTHER
Responsible Party
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Principal Investigators
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Yawen Wang, Ph.D
Role: STUDY_CHAIR
First Affiliated Hospital of Xian Jiaotong University
Locations
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First Affiliated Hospital of Xian Jiaotong University
Xi'an, Shaanxi, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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XJTU1AF-CRF-2015-009
Identifier Type: -
Identifier Source: org_study_id
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