Expression of HOXA10 and HOXA11 in the Endometrium of Infertility Patients With an Endometrial Polyp Before and After Polypectomy

NCT ID: NCT02761278

Last Updated: 2016-05-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-07-31

Study Completion Date

2017-07-31

Brief Summary

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The aim of this study is to measure the expression of HOXA10 and HOXA11 in the endometrium of infertility patients with an endometrial polyp before and after polypectomy. HOXA10 and HOXA11 are well-established markers of implantation. It is uncertain as to whether an endometrial polyp interferes with embryo implantation. A higher expression of HOXA10 and HOXA11 after polypectomy can indicate that endometrial polyp does interfere with embryo implantation.

Detailed Description

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Conditions

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Infertility

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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HOXA10 and HOXA11 Expression Before Polypectomy

A biopsy will taken in infertility patients with endometrial polyp before polypectomy

Group Type ACTIVE_COMPARATOR

Endometrial biopsy

Intervention Type PROCEDURE

HOXA10 and HOXA11 Expression After Polypectomy

A biopsy will taken in infertility patients with endometrial polyp 1-3 months after polypectomy

Group Type ACTIVE_COMPARATOR

Endometrial biopsy

Intervention Type PROCEDURE

Interventions

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Endometrial biopsy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Infertile women with endometrial polyp

Exclusion Criteria

* Endometriosis
* Polycystic ovary syndrome
* Hydrosalpinx
* Sub-mucus myoma
* Women who have taken hormonal therapy in the preceding month
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Hillel Yaffe Medical Center

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Guy Shrem, MD

Role: PRINCIPAL_INVESTIGATOR

Hillel Yaffe Medical Center

Central Contacts

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Guy Shrem, MD

Role: CONTACT

Other Identifiers

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HYMC-0039-16

Identifier Type: -

Identifier Source: org_study_id

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