Evaluation of Blood Flow Characteristics in Glaucoma Using Optical Coherence Tomography Angiography (OCT-A).

NCT ID: NCT02757677

Last Updated: 2022-05-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-12-31

Study Completion Date

2019-12-31

Brief Summary

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The investigators aim to evaluate the efficacy of the new Optical Coherence Tomography based Angiography (OCT-A) softwares in the diagnosis and management of glaucoma.

Detailed Description

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Conditions

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Glaucoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Longitudinal arm

Evaluate optic nerve head blood flow using the new OCT-A software in surgically and medically treated glaucoma patients and in different types of glaucoma

Optical Coherence Tomography based Angiography

Intervention Type DEVICE

A contrast-free, noninvasive technology to identify blood vessels in the eye

24-h Intraocular pressure (IOP) arm

Evaluate the correlation between circadian IOP changes and optic nerve head blood flow using the new OCT-A software

Optical Coherence Tomography based Angiography

Intervention Type DEVICE

A contrast-free, noninvasive technology to identify blood vessels in the eye

Surgery arm

Evaluate blood flow using the new OCT-A software in surgically treated glaucoma patients

Optical Coherence Tomography based Angiography

Intervention Type DEVICE

A contrast-free, noninvasive technology to identify blood vessels in the eye

Interventions

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Optical Coherence Tomography based Angiography

A contrast-free, noninvasive technology to identify blood vessels in the eye

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of open angle glaucoma (OAG) including pseudo-exfoliative and pigmentary glaucoma.
* Documented glaucomatous visual field damage (in the previous 12 months with mean defect (MD) \> 2.0 dB)
* Structural and/or functional glaucomatous damage
* Have given written informed consent, prior to any investigational procedures

Exclusion Criteria

* Patients with allergy to corneal anesthetic
* Patients not able to understand the character and individual consequences of the investigation
* Participation in other clinical research within the last 4 weeks
* Other diseases that may cause visual field loss or optic disc abnormalities
* Refractive error of \> +3.00D or \< -7.00D
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Swiss Vision Network

OTHER

Sponsor Role lead

Responsible Party

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Dr. Kaweh Mansouri

dr. Kaweh Mansouri

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kaweh Mansouri, MD

Role: PRINCIPAL_INVESTIGATOR

Glaucoma center, Montchoisi clinic, Swiss vision network

Locations

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Glaucoma center, Montchoisi clinic

Lausanne, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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GR-02

Identifier Type: -

Identifier Source: org_study_id

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