Contrast Enhanced SWI for Carotid Plaque Imaging

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

25 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-08-31

Study Completion Date

2019-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study aims to compare image-based characteristics of carotid walls between symptomatic side and the opposite side. The design of this study is phase IV, prospective observational study.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Advanced Ultrasound Methods in the Assessment of Carotid Plaque Instability

NCT03672955

Internal Carotid Artery Stenosis With Infarction

ACTIVE_NOT_RECRUITING

New Technologies to Determine Carotid Plaque Vulnerability

NCT02224339

Atherosclerosis Carotid Artery Plaque

COMPLETED

The Evaluation of Tomographic 3D Ultrasound for the Assessment of Vascular Pathology

NCT04318171

Carotid Artery Plaque

COMPLETED

Risk Assessment of Carotid Plaques Using 3D Contrast-Enhanced Ultrasound

NCT04643431

Carotid Atherosclerosis

ACTIVE_NOT_RECRUITING PHASE4

Mechanism and Predictor of Side Branch Jailing

NCT00553670

Bifurcating Coronary Artery Lesions Main Branch Stent Implantation Side Branch Jailing

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Atherosclerosis of craniocervical arteries are one of most important causes of stroke. Carotid artery is the most frequent site of atherosclerosis. Recent research in carotid artery covers not only morphology of lumen but also direct visualization of carotid plaque or vessel wall. Vulnerable carotid plaques share pathologic features of intra-plaque inflammation and hemorrhage. There have been reports about post-contrast SWI in the field of vascular imaging. We hypothesized SWI is so sensitive to gadolinium based contrast agent and hemorrhage that contrast-enhanced SWI can visualize vulnerable carotid plaque. The purpose of this study is to investigate gadolinium-enhanced SWI in detection of vulnerable carotid plaque and compare it with MP-RAGE and DANTE T1-SPACE. This can be used to guide proper treatment for stroke.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Carotid Plaque Imaging

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Patients with acute or recent (within 3months) stroke

Methods of carotid wall imaging

Intervention Type OTHER

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Methods of carotid wall imaging

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients with acute or recent (within 3months) stroke or TIA
* 50-99% stenosis of internal carotid artery by NASCET criteria
* Written informed consent, prior to registration

Exclusion Criteria

* Hemorrhagic stroke
* Previous history of carotid endarterectomy (CEA), angioplasty, or stenting
* Contraindication for MR imaging
* Hypersensitivity to gadolinium based contrast media
* Pregnant or lactating women
* Patients under age of 19-year-old
* Renal condition : eGFR \< 60
* Patients unable and/or unwilling to comply with treatment or study instructions.

Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No