Carotid Ultrasound Sub-Study of the Familial Atherosclerosis Study-observational Study
NCT ID: NCT00976014
Last Updated: 2021-12-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
76 participants
OBSERVATIONAL
2006-12-26
2012-05-09
Brief Summary
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One group of subjects has had long-term intensive lipid altering therapy (lowering LDL-C plus raising HDL-C). The second group of patients has been on conventional "standard of care" treatment for carotid stenosis.
The study will look at the Carotid Intima-media Thickness (CMIT) in both groups.
Hypothesis: CIMT will differ between the two groups, such that the CIMT will be less in the subjects on intensive lipid altering therapy.
Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Intensive Lipid-lowering therapy
Subjects on intensive long-term lipid lowering therapy (lowering LDL-C plus raising of HDL-C).
No interventions assigned to this group
Usual Care
Subjects with Atherosclerosis who have been on conventional "standard of care" treatment.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Usual Care Group: Subjects who were in the FATS OS Study in the past, but have since quit the study and opted for conventional "standard of treatment".
Exclusion Criteria
MALE
No
Sponsors
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University of Washington
OTHER
Responsible Party
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Xue-Qiao Zhao
Research Professor of Medicine, Cardiology
Principal Investigators
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Xue-Qiao Zhao, MD
Role: PRINCIPAL_INVESTIGATOR
University of Washington
Locations
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University of Washington
Seattle, Washington, United States
Countries
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References
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Phan BA, Moore AB, Davis J, Pollan LJ, Neradilek B, Brown BG, Zhao XQ. Prolonged combination lipid therapy is associated with reduced carotid intima-media thickness: a case-control study of the 20-year Familial Atherosclerosis Treatment - Observational Study (FATS-OS). J Clin Lipidol. 2014 Sep-Oct;8(5):489-93. doi: 10.1016/j.jacl.2014.07.004. Epub 2014 Jul 12.
Other Identifiers
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30519
Identifier Type: -
Identifier Source: org_study_id