Comparison of Trelstar Versus Lupron or Zoladex in Advanced Prostate Cancer

NCT ID: NCT02749825

Last Updated: 2016-04-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE4

Total Enrollment

41 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-09-30

Study Completion Date

2006-07-31

Brief Summary

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This research study looks at Testosterone levels in patients receiving Trelstar versus those receiving Lupron or Zoladex. These drugs have been approved for treatment of Prostate Cancer by the FDA.

Detailed Description

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Patients who are currently receiving Lupron or Zoladex will be consented and then randomized to receive either continued treatment with the drug they have been on, or will be randomized to Trelstar for a period of 3 months. At the end of that period, testosterone and prostate serum antigen (PSA) levels will be drawn and compared to their previous levels to determine if Trelstar is as effective as the previous treatment.

Conditions

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Prostate Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Trelstar

Per prescribing information

Group Type EXPERIMENTAL

Trelstar

Intervention Type DRUG

As labeled

Lupron

Per prescribing information

Group Type ACTIVE_COMPARATOR

Lupron

Intervention Type DRUG

As labeled

Zoladex

Per prescribing information

Group Type ACTIVE_COMPARATOR

Zoladex

Intervention Type DRUG

As labeled

Interventions

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Trelstar

As labeled

Intervention Type DRUG

Lupron

As labeled

Intervention Type DRUG

Zoladex

As labeled

Intervention Type DRUG

Other Intervention Names

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Triptorelin pamoate luprolide acetate for depot suspension goserelin acetate

Eligibility Criteria

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Inclusion Criteria

* Advanced Prostate Cancer
* Currently taking Lupron or Zoladex
* Stable PSA
* Baseline testosterone below castration level
* Life expectancy \> 6 months
* Eastern Cooperative Oncology Group performance status of 0-2
* Signed, approved informed consent.

Exclusion Criteria

* Known hypersensitivity to any leuteinizing hormone releasing hormone (LHRH) agonist
* Ongoing therapy with hyperprolactinemic agents
* Antiandrogen therapy within 28 days prior to study start
* Prior Orchiectomy, hypophysectomy or adrenalectomy
* Chemotherapy, radiotherapy, or prostatectomy within 28 days prior to study start
* Use of any investigational agent 3 months prior to enrollment
* Use of systemic corticosteroids within 28 days or during study
* Other malignancies within 2 yrs prior to study start, except curatively treated skin cancers
* Severe kidney or liver failure, based on adequate lab values
* Other medical conditions which would be likely to interfere with compliance or completion of study requirements
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Manyak, Michael, M.D.

INDIV

Sponsor Role collaborator

Watson Pharmaceuticals

INDUSTRY

Sponsor Role collaborator

Pharmatech

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michael Michael Manyak, MD

Role: PRINCIPAL_INVESTIGATOR

Georege Washington University

Locations

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Arizona Urologic Specialists

Tucson, Arizona, United States

Site Status

Heritage Physician Group - Urology Department

Hot Springs, Arkansas, United States

Site Status

California Oncology of the Central Valley

Fresno, California, United States

Site Status

San Bernardino Urological Associates Medical Group

San Bernardino, California, United States

Site Status

UroSearch

Ocala, Florida, United States

Site Status

Scott A Slavis, MD, PC

Las Vegas, Nevada, United States

Site Status

Shaukat M Qureshi, MD

Pennsville, New Jersey, United States

Site Status

Brooklyn Heights Urology Associates

Brooklyn, New York, United States

Site Status

Jazrawi-Atallah, P.C.

Brooklyn, New York, United States

Site Status

Albemarle Urology Clinic, PA

Albemarle, North Carolina, United States

Site Status

Raj P. Chopra MD, PC

Bloomsburg, Pennsylvania, United States

Site Status

Countries

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United States

Related Links

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http://www.pharmatech.com

Pharmatech - The Research Link website

Other Identifiers

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PUI-02809

Identifier Type: -

Identifier Source: org_study_id

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