Sensitive Troponin I in Out-of-hospital Cardiac Arrest

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

159 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-10-31

Study Completion Date

2018-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Troponin is a major diagnostic criterion of acute myocardial infarction (AMI) which confirms myocardial damage and necrosis. In out-of-hospital cardiac arrest (OHCA) patients its dynamics and diagnostic value is often controversial and has not been well described. Most of prior studies were retrospective, using first generation troponin assays and assessing only admission troponin. The aim of this work is to correlate dynamics of sensitive troponin I with urgent coronary angiography.

Patients resuscitated after OHCA will be prospectively divided in three groups based on the results of their urgent angiographies. Serial assessment of sensitive troponin I will be obtained over initial 48 hours.

We expect admission troponin will not be predictive of AMI. Over next hours troponin levels will be highest in patients with acute coronary lesion, lower in stable obstructive coronary disease and insignificant in non-obstructive coronary disease. We also expect significant difference in highest values and dynamics of troponin in sub-group with spontaneous reperfusion (TIMI flow 2 and 3) comparing to patients with coronary occlusion (TIMI flow 0 and 1). In patients with non-obstructive disease we expect troponin levels to correlate with duration of cardiac arrest, number of external electric shocks and cumulative dose of adrenaline administered.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Induced Myocardial Ischemia: a Serial Troponin T and Troponin I Measurements

NCT03203057

Acute Coronary Syndrome Cardiac Ischemia

COMPLETED

High-sensitivity Troponin in Cardiac Surgery

NCT01913873

Heart; Dysfunction Postoperative, Cardiac Surgery Myocardial Infarction Myocardial Injury

COMPLETED PHASE4

Clinical and Economic Outcomes of High Sensitivity Troponin for no ST Elevation Myocardial Infarction in Patients With Chest Pain in Emergency Departments in Italy-An Observational Study

NCT03489603

NSTEMI - Non-ST Segment Elevation MI

COMPLETED

Point-of-Care Troponin Testing in the Emergency Department

NCT06845826

Acute Coronary Syndromes

NOT_YET_RECRUITING NA

Troponin POCT in the Diagnosis of an Acute Myocardial Infarction

NCT03400553

Acute Myocardial Infarction Troponin

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cardiac Arrest Acute Coronary Lesion Stable Obstructive Coronary Disease Non-obstructive Coronary Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Acute coronary syndrome culprit coronary lesion

Blood sample collection

Intervention Type OTHER

Eight blood samples in each patient within 48 hours to perform Troponin I measurement.

Stable obstructive coronary artery disease

Blood sample collection

Intervention Type OTHER

Eight blood samples in each patient within 48 hours to perform Troponin I measurement.

Non-obstructive coronary artery disease

Blood sample collection

Intervention Type OTHER

Eight blood samples in each patient within 48 hours to perform Troponin I measurement.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Blood sample collection

Eight blood samples in each patient within 48 hours to perform Troponin I measurement.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* female and male over 18 years old
* comatose survivors after out-of-hospital cardiac arrest (OHCA)
* absence of an obvious non-coronary cause
* urgent coronary angiography at admittance
* less than 3 hours from OHCA to first troponin assessment at admittance

Exclusion Criteria

* sub-acute myocardial infarction
* coronary spasms or in-stent thrombosis within first 48 hours after admission
* Coronary surgery or death within first 48 hours after admission

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No