Different Regulation of Immune Cells in Patients With Preeclampsia

NCT ID: NCT02691364

Last Updated: 2016-02-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-04-30

Study Completion Date

2017-06-30

Brief Summary

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Adaptation of the maternal immune system to accommodate the semi-allogeneic fetus is necessary for pregnancy success. Dysregulation of this immune adaptation is implicated in reproductive disorders as infertility, recurrent miscarriage, fetal growth restriction, and preeclampsia. The mechanisms being responsible for fetal tolerance are not known. Several T cell subsets have been implicated in fetal tolerance. The effects of preeclampsia on memory cells are not known. The main objective of this study is to analyze the effect of preeclampsia on levels of immune cells.

Detailed Description

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Conditions

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Preeclampsia Pregnancy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Healthy

Healthy women

Blood withdrawal

Intervention Type PROCEDURE

Preeclamptic

Pregnant women with preeclampsia

Blood withdrawal

Intervention Type PROCEDURE

Interventions

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Blood withdrawal

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* healthy
* written informed consent
* 18-40 years

Exclusion Criteria

* smoking
* immune related disorders (other than preeclampsia)
* fever / illness within the last month
* infertility
* body mass index \<18 or \>30
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University Medical Center Groningen

OTHER

Sponsor Role lead

Responsible Party

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Jelmer Prins

MD PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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2015/612

Identifier Type: -

Identifier Source: org_study_id

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