CMF Bone Stimulation as Adjunct to Surgical Treatment of Ankle Fractures

NCT ID: NCT02688855

Last Updated: 2022-03-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

217 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-23

Study Completion Date

2022-06-30

Brief Summary

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The OL1000 is intended to be used as a non-invasive adjunctive treatment for adult males or females that have sustained a closed, unstable ankle fracture that requires surgical treatment for stabilization. The initiation of the adjunctive treatment is to begin within 11 days of surgical stabilization.

Detailed Description

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Conditions

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Bimalleolar Ankle Fractures

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Investigational Group

Standard Rigid Fixation + Active OL1000 device

Group Type EXPERIMENTAL

Active Combined Magnetic Field OL1000 Bone Growth Stimulator

Intervention Type DEVICE

Active CMF OL1000 Device

Control Group

Standard Rigid Fixation + Sham OL1000 device

Group Type SHAM_COMPARATOR

Sham Combined Magnetic Field OL1000 Bone Growth Stimulator

Intervention Type DEVICE

Sham CMF OL1000

Interventions

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Active Combined Magnetic Field OL1000 Bone Growth Stimulator

Active CMF OL1000 Device

Intervention Type DEVICE

Sham Combined Magnetic Field OL1000 Bone Growth Stimulator

Sham CMF OL1000

Intervention Type DEVICE

Other Intervention Names

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CMF OL1000 CMF OL1000

Eligibility Criteria

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Inclusion Criteria

* Subject is diagnosed with an unstable, closed, isolated fracture of the ankle and underwent operative stabilization with plate(s) and/or screws (Weber Ankle Fracture Classification B and C)

Exclusion Criteria

* Subject has an open fracture
* Subject has any additional fractures of another bone besides the ankle fracture that is to be treated in the study including the contralateral ankle
* Surgical stabilization was definitively performed with an external fixation system
* Surgical stabilization was performed in such a manner that it will result in a fusion of the ankle joint
* Malreduced Ankle as described by Phillips, et al 1985 JBJS
* Surgical procedure included the use of osteoinductive materials in addition to rigid fixation
* BMI ≥ 40 kg/m2
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Encore Medical, L.P.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Arizona

Tucson, Arizona, United States

Site Status RECRUITING

Cedars-Sinai Medical Center

Los Angeles, California, United States

Site Status RECRUITING

Orthopaedic Associates of South Broward, P.A.

Hollywood, Florida, United States

Site Status RECRUITING

OrlandoHealth

Orlando, Florida, United States

Site Status WITHDRAWN

William Beaumont Hospital

Royal Oak, Michigan, United States

Site Status RECRUITING

Rutgers Biomedical Health Sciences

Newark, New Jersey, United States

Site Status RECRUITING

University of Rochester

Rochester, New York, United States

Site Status RECRUITING

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

University of Virginia

Charlottesville, Virginia, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Akujuobi Udu, MS

Role: CONTACT

248-914-0150

Jessica Knowlton, MS

Role: CONTACT

732-666-7550

Facility Contacts

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Daniel Latt, MD

Role: primary

520-626-5472

Charles Moon, MD

Role: primary

310-423-1620

Steven Steinlauf, MD

Role: primary

954-854-3463

Zachary Vaupel, MD

Role: primary

248-551-0194

Sheldon Lin, MD

Role: primary

973-972-2184

Kyle Judd, MD

Role: primary

585-276-7790

Daniel Farber, MD

Role: primary

215-829-3613

Minton Cooper, MD

Role: primary

434-243-0256

References

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Phillips WA, Schwartz HS, Keller CS, Woodward HR, Rudd WS, Spiegel PG, Laros GS. A prospective, randomized study of the management of severe ankle fractures. J Bone Joint Surg Am. 1985 Jan;67(1):67-78.

Reference Type RESULT
PMID: 3881447 (View on PubMed)

Olerud C, Molander H. A scoring scale for symptom evaluation after ankle fracture. Arch Orthop Trauma Surg (1978). 1984;103(3):190-4. doi: 10.1007/BF00435553.

Reference Type RESULT
PMID: 6437370 (View on PubMed)

Related Links

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Other Identifiers

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PS-607

Identifier Type: -

Identifier Source: org_study_id

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