Dose-finding and Pharmacokinetic Study of DpC, Administered Orally to Patients With Advanced Solid Tumors

NCT ID: NCT02688101

Last Updated: 2019-02-21

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 14 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-04-11
• Study Completion Date: 2017-10-26

Brief Summary

Multicenter, open-label, dose-escalation and pharmacokinetic study.

Detailed Description

Multicenter, open-label, phase 1 study of DpC administered orally to patients with advanced solid tumors. The study will be conducted in two parts. In the first phase successive cohorts of patients (3+3) will receive escalating doses of DpC until the maximum tolerated dose (MTD) is reached. MTD is based on tolerability observed during the first 28 days of treatment. The second part of the study involves treatment of expansion cohorts (10-15 patients each) in specific indications to confirm the tolerability of treatment at the recommended phase 2 dose and schedule and evaluate evidence of anti-tumor activity.

Conditions

Neoplasms

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

DpC

DpC capsules, administered orally

Group Type: EXPERIMENTAL

DpC

Intervention Type: DRUG

iron chelator

Interventions

DpC

iron chelator

Intervention Type: DRUG

Other Intervention Names

Dp4cycH4mT

Eligibility Criteria

Inclusion Criteria

• Signed informed consent prior to initiation of any study-specific procedures;
• Histologically or cytologically confirmed diagnosis of an advanced or metastatic solid tumor for which standard therapy either does not exist or has proven ineffective, intolerable, or unacceptable for the patient;
• At least one measurable lesion as defined by RECIST v1.1, except for patients with castrate resistant prostate cancer, who may be enrolled with objective evidence of disease per PCWG2 criteria, and patients with ovarian cancer who may be enrolled without measurable disease but who are evaluable by CA125 per GCIC criteria;
• life expectancy at least 3 months;
• ECOG performance status 0-1;
• Adequate bone marrow reserve, cardiac, renal and liver function, defined by
• absolute neutrophil count at least 1.5 x 10(9)/L;
• platelet count at least 100 x 10(9)/L;
• hemoglobin at least 9 g/dL;
• ferritin at least 50 ug/L;
• ECHO shows ejection fraction at least 50% and no evidence of cardiac dysfunction;
• creatinine clearance >50 mL/min (Cockcroft & Gault formula);
• AST/ALT no more than 3 x ULN (5 x ULN if liver or bone involvement);
• serum albumin at least 28 g/L;
• INR no more than 1.5 x ULN;
• At least 3 weeks since chemotherapy, immunotherapy, hormone therapy, r other anticancer therapy or surgical intervention or at least 3 half-lie for monoclonal antibodies;
• Patients with castrate-resistant prostate cancer must maintain ongoing androgen deprivation therapy to provide serum testosterone <50 mg/dL;
• Patients receiving bisphosphonate or denosumab therapy must be on stable doses for at least 4 weeks before initiating study treatment.

Exclusion Criteria

• Inability to swallow oral medications or presence of a GI disorder deemed to jeopardize intestinal absorption of DpC;
• Persistent grade >1 clinically significant toxicities related to prior anticancer treatment (except alopecia);
• Known primary CNS malignancy or CNS involvement (except for brain mets that have been treated and are stable and patient is off steroids);
• History of prior to concomitant malignancies (other than fully excised non-melanoma skin cancer, cured in situ cervical carcinoma, early stage bladder cancer or DCIS of breast) within 3 years of study entry;
• History of atrial fibrillation or evidence of atrial enlargement on baseline ECHO;
• History of hemoglobinopathy;
• Current use of iron chelation therapy;
• Other serious illness or medial condition;
• Participation in another clinical trial or treatment with any investigational drug within 30 days prior to study entry;
• Current use of anticoagulants at therapeutic levels;
• Pregnant or breast-feeding patients and men and women of child-bearing potential not using effective contraception while on study treatment

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Collaborative Medicinal Development Pty Limited

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Linda Mileshkin, MD

Role: PRINCIPAL_INVESTIGATOR

Peter MacCallum Cancer Centre, Australia

Locations

Lifehouse Cancer Treatment Centre

Sydney, New South Wales, Australia

Olivia Newton John Cancer Centre

Heidelberg, Victoria, Australia

Monash Cancer Center

Melbourne, Victoria, Australia

Peter MacCallum Cancer Centre

Melbourne, Victoria, Australia

Countries

Australia

Other Identifiers

CMD-2015-001

Identifier Type: -

Identifier Source: org_study_id