Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The main purpose of this study is to observe the clinical effect of intrathecal administration of liposomal amphotericin B in Cryptococcal Meningitis without Acquired Immune Deficiency Syndrome (AIDS).

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Meropenem Penetration Across BBB in Patients With CNS Infection and Optimization of Meropenem Treatment

NCT02506686

Central Nervous System Infections

COMPLETED PHASE4

Etiology of Orphan Community-based Meningitis and Meningo-encephalitis.

NCT02868593

Community-based Meningitis Meningo-encephalitis

UNKNOWN NA

Establishment of Prevention and Control System of Central Nervous System Infection

NCT04722328

Central Nervous System (CNS) Infection Encephalitis Meningitis

NOT_YET_RECRUITING

Meningitis: Burden, Causes, Screening and Prevention in Rural Northern Uganda

NCT05496673

Meningitis

RECRUITING NA

Evaluation of a Serology Diagnostic Kit for the Detection of Genital Mycoplasma in Pregnancy

NCT01281319

Genital Mycoplasma Infection High Risk Pregnancy Preterm Labor

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cryptococcal Meningitis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Intrathecal administration group

Group Type EXPERIMENTAL

Liposomal amphotericin B

Intervention Type DRUG

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Liposomal amphotericin B

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Cryptococcus neoformans are found in CSF

Exclusion Criteria

* Patients with serious heart, lung, liver and renal insufficiency.
* Patients who took broad-spectrum antibiotics and corticosteroids for a long-term.
* Patients with AIDS or obvious immunodeficiency.
* Patients with long term dialysis or intravenous catheter.
* Patients with other brain organic disease such as purulent meningitis, intracranial swelling, etc.

Minimum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No