The Maternal Cellular Immune System and Cytomegalovirus Intrauterine Infection
NCT ID: NCT01081379
Last Updated: 2019-11-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2014-02-28
2022-08-31
Brief Summary
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Detailed Description
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Our hypothesis is that there is a correlation between cellular immune response of the mother to CMV infection and viral transmission to the fetus.
Pregnant women with primary CMV infection (40% of whom are expected to be transmitters)and with pre-conception immunity will participate in this study.
Blood from these women will be incubated with CMV peptides and T cell activation will be measured by the secretion of various cytokines.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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pre-conception immunity
pre-conception immunity- pregnant women with CMV seropositive
No interventions assigned to this group
primary CMV infection
primary CMV infection- pregnant women with primary CMV infection (defined as CMV IgG sero-conversion, the presence of low avidity IgG antibodies or the presence of IgM with no previous IgG antibodies).
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* CMV IgG sero-conversion or the presence of low avidity IgG antibodies or the presence of IgM with no previous IgG antibodies.
Exclusion Criteria
* Other pregnancy complications
18 Years
50 Years
FEMALE
Yes
Sponsors
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Shaare Zedek Medical Center
OTHER
Responsible Party
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Yedidia Yifat
Yechiel Schlesinger, MD, Shaare Zedek Medical Center.
Principal Investigators
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Yechiel Schlesinger, M.D.
Role: PRINCIPAL_INVESTIGATOR
Shaare Zedek Medical Center
Locations
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Shaare Zedek Medical Center
Jerusalem, , Israel
Countries
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Central Contacts
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Other Identifiers
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Schlesinger - CMV
Identifier Type: -
Identifier Source: org_study_id
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