Effect of Burn Size on Cytomegalovirus Reactivation and Correlates of T Cell Immune Function in Burned Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-03-31

Study Completion Date

2011-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to evaluate the effect of burn injury on the human immune system with a focus on cytomegalovirus (CMV) reactivation and the immunologic correlates of latent viral reactivation.

Subjects will be patients admitted to the North Carolina Jaycee Burn Center with burn injury.

Blood samples will be collected over time and will be evaluated for CMV reactivation and immune cell phenotype.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Immune Response and Cytomegalovirus in Intensive Care Unit (ICU) Patients

NCT00699868

Cytomegalovirus Infection

COMPLETED NA

The Maternal Cellular Immune System and Cytomegalovirus Intrauterine Infection

NCT01081379

Pregnant Women Cytomegalovirus Infections

UNKNOWN

Immunological Characteristics of Maternal-fetal Transmission of Cytomegalovirus in Pregnancy

NCT02129465

Pregnancy Cytomegalovirus Infections Congenital Infection

UNKNOWN

Cytomegalovirus (CMV) Transmission by Frozen Breast Milk in Preterms

NCT00668798

Cytomegalovirus

SUSPENDED

Biomarkers of Cytomegalovirus Fetal Infection and Disease

NCT03090841

Cytomegalovirus Congenital

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The purpose of this research study is to learn about infections and the immune system in people who suffer from burn injuries. The immune system changes after burn injury and infection is one of the most common complications. Cytomegalovirus (CMV) is a virus that most people are exposed to early in life; once you are exposed it lays inactive in your body forever. When the immune system is suppressed, this virus can reactivate. We would like to measure how this virus makes copies of itself in the blood stream in people with a burn injury and to look at cell markers of the immune system.

This study involves baseline and weekly blood draws for approximately 8 weeks. If blood tests show CMV infection, further monitoring of blood work may be needed after eight weeks.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Burns Cytomegalovirus

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Burn injury,
* Positive CMV IgG level confirmative of previous CMV infection and latency.

Exclusion Criteria

* Immunocompromising conditions including HIV/AIDS,
* End-stage renal disease,
* End-stage liver disease,
* Pregnancy,
* Rheumatologic or collagen-vascular disease requiring chronic use of steroids,
* Chronic use of immunosuppressive agents,
* Recent chemotherapy, and
* History of solid organ or allogeneic stem cell transplant.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No