Measurement of Energy Metabolism in Infants

NCT ID: NCT02683473

Last Updated: 2025-07-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-03-16

Study Completion Date

2025-06-30

Brief Summary

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The purpose of this study is to measure energy expenditure during the first 3 months of life in infants.

Detailed Description

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This study intends to establish the feasibility of undertaking comprehensive metabolic phenotyping in infants. The overarching aim is to complete a prospective assessment of energy expenditure in the new infant metabolic chamber approximately one week apart to determine the accuracy and precision of infant protocols related to energy metabolism (sleeping metabolic rate, resting metabolic rate, diet-induced thermogenesis) and physical activity. This cross-sectional study will answer the following questions:

1. What is the test re-test reliability of measuring energy expenditure (sleeping metabolic rate, resting metabolic rate, diet-induced thermogenesis) in an infant under the same conditions, 5-7 days apart?
2. What is the reliability of 24h energy expenditure estimated by the infant metabolic chamber in comparison to a 7-day doubly labeled water study?
3. How do energy expenditure measurements in infants need to be adjusted to account for variability in infant size and body composition?

Conditions

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Infant Development Infant Overnutrition

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Infants

Infants aged 1-3 months

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Healthy, full-term infant
* Aged 1 month (28 days) to 3 months (12 weeks, 6 days) at the first visit
* Exclusively fed breast milk and/or infant formula
* Willing to accept doubly-labeled water

Exclusion Criteria

* Unable to complete 3 clinic visits within about 14 days at Pennington Biomedical Research Center
* Born preterm (\< 37 weeks gestation)
* Congenital abnormality or disability
* Gastric reflux
* Acute illness within 7 days of the study (fever, diarrhea)
* Use of medications to treat a chronic condition (does not include use of vitamin supplements or PRN medication for flatulence or reflux such as Pepcid)
Minimum Eligible Age

1 Month

Maximum Eligible Age

3 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

Sponsor Role collaborator

Pennington Biomedical Research Center

OTHER

Sponsor Role lead

Responsible Party

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Leanne Redman

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Leanne M Redman, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Pennington Biomedical Research Center

Locations

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Pennington Biomedical Research Center

Baton Rouge, Louisiana, United States

Site Status

Countries

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United States

Other Identifiers

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P30DK072476-10

Identifier Type: NIH

Identifier Source: secondary_id

View Link

PBRC 2015-061

Identifier Type: -

Identifier Source: org_study_id

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