Study Results
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View full resultsBasic Information
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COMPLETED
NA
47 participants
INTERVENTIONAL
2016-04-30
2021-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Intervention light
30 minutes of intervention systematic light exposure daily for 4 weeks.
Intervention systematic light exposure
Bright light using Litebook device.
Comparison light
30 minutes of comparison systematic light exposure daily for 4 weeks.
Comparison systematic light exposure
Dim light using modified Litebook device.
Interventions
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Intervention systematic light exposure
Bright light using Litebook device.
Comparison systematic light exposure
Dim light using modified Litebook device.
Eligibility Criteria
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Inclusion Criteria
2. 1 to 5 years post-HSCT,
3. Relapse-free since most recent HSCT,
4. Age 21 or older,
5. English language proficient
6. Able to provide informed consent
7. Endorse subjective cognitive impairment.
Exclusion Criteria
2. Visual, hearing, or physical impairment sufficient to interfere with cognitive testing or participation,
3. Have a history of whole brain irradiation or surgery,
4. Active diagnosis of autoimmune and/or inflammatory disorder or disorders that may influence immune processes,
5. Chronic use of oral steroid medication,
6. History of systematic light exposure treatment,
7. Diagnosed sleep apnea or narcolepsy,
8. Use of photosensitizing medications,
9. Plan to travel across meridians during the study,
10. Work night, early morning, or swing shifts,
11. Adults unable to consent, individuals who are not yet adults, pregnant women and prisoners will be excluded from the study.
21 Years
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
Northwestern University
OTHER
Responsible Party
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Lisa M. Wu
Assistant Professor
Principal Investigators
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Lisa M Wu, PhD
Role: PRINCIPAL_INVESTIGATOR
Northwestern University
Locations
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Northwestern University Feinberg School of Medicine
Chicago, Illinois, United States
Countries
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References
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Wu LM, Valdimarsdottir HB, Amidi A, Reid KJ, Ancoli-Israel S, Bovbjerg K, Fox RS, Walker L, Matharu A, Kaseda ET, Galvin JP, Adekola K, Winkel G, Penedo F, Redd WH. Examining the Efficacy of Bright Light Therapy on Cognitive Function in Hematopoietic Stem Cell Transplant Survivors. J Biol Rhythms. 2022 Oct;37(5):471-483. doi: 10.1177/07487304221107833. Epub 2022 Jul 29.
Provided Documents
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Document Type: Study Protocol, Statistical Analysis Plan, and Informed Consent Form
Other Identifiers
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STU00201700
Identifier Type: -
Identifier Source: org_study_id
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