Parent Education and Choice About Newborn Screening and Bloodspot Retention

NCT ID: NCT02676245

Last Updated: 2016-02-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

664 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-09-30

Study Completion Date

2014-10-31

Brief Summary

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To address the content, timing, efficacy, and impact of prenatal education about newborn screening generally and sample retention specifically.

Detailed Description

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It is widely recognized that new parents receive insufficient information about newborn screening (NBS) and little or no information regarding the retention of residual newborn screening samples. Our current research (R01 HD058854) clearly demonstrates that parents are supportive of NBS and the research use of residual specimens, but they want information before the child is born and want an informed choice regarding the retention and use of residual samples. Previous research has outlined the basic elements of what parents want to know about NBS generally. However, given that many states are adopting an "opt-out" approach for residual samples, it is unclear what basic information parents want to know to enable an informed choice about this practice. While it is recognized that retention and use of residual NBS samples is a valuable research resource, there are prevalent concerns in the NBS community that discussion of this will lead some parents to decline NBS altogether. Some authorities have suggested that discussions of NBS and residual sample retention be conducted separately to reduce the risk that parents will confuse the issues and decline NBS altogether.

To address this the project has the following specific aims:

Specific Aim 1) To determine what pregnant women, young mothers, and their partners want to know regarding the retention and use of residual bloodspot samples

Specific Aim 2) To create multimedia educational tools to be used in the prenatal care environment that will provide basic information about NBS and the core information determined through Specific Aim 1 about residual sample retention and use.

Specific Aim 3) To determine the impact of the prenatal education intervention on parental knowledge, attitudes, and decisions regarding NBS services and the retention and use of residual samples in diverse populations of English and Spanish speaking pregnant women.

Specific Aim 4) To examine the normative/ethical implications of the results of SA3 for the conduct of state NBS programs. Recommendations on the content and timing of parental NBS education will be developed.

Conditions

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Neonatal Screening

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Viewing NBS + DBS Educational Movies

Group A: pregnant women who will view the NBS and residual specimen movies and printed materials during one visit between 30 and 40 weeks gestation.

Group Type EXPERIMENTAL

Viewing Newborn Screening movie

Intervention Type BEHAVIORAL

NBS Movie and printed brochure were viewed by the participants

Viewing Residual Dried Blood Spot movie

Intervention Type BEHAVIORAL

DBS Movie and and printed brochure were viewed by the participants

Viewing NBS Educational Movie only

Group B: pregnant women who will view the NBS movie only and printed materials at one visit between 30 and 40 weeks. The movies will be presented on a tablet PC.

Group Type EXPERIMENTAL

Viewing Newborn Screening movie

Intervention Type BEHAVIORAL

NBS Movie and printed brochure were viewed by the participants

No Educational Interventions

Control Group: pregnant women who will receive no experimental intervention during pregnancy or the postpartum period but will receive whatever information is routinely provided by their OB clinic and/or delivery center.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Viewing Newborn Screening movie

NBS Movie and printed brochure were viewed by the participants

Intervention Type BEHAVIORAL

Viewing Residual Dried Blood Spot movie

DBS Movie and and printed brochure were viewed by the participants

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Adult (\> 18 years) women
* Uncomplicated pregnancy
* English and Spanish speaking
* Partners of pregnant women who have give birth.

Exclusion Criteria

* Women younger than 18 years
* Complicated pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Case Western Reserve University

OTHER

Sponsor Role collaborator

Intermountain Health Care, Inc.

OTHER

Sponsor Role collaborator

Albert Einstein College of Medicine

OTHER

Sponsor Role collaborator

University of California, San Francisco

OTHER

Sponsor Role collaborator

National Human Genome Research Institute (NHGRI)

NIH

Sponsor Role collaborator

University of Utah

OTHER

Sponsor Role lead

Responsible Party

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Jeffrey Botkin

Professor of Pediatrics, Chief Division of Medical Ethics and Humanities, Associate Vice President for Research

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jeffrey R Botkin, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

University of Utah

References

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Botkin JR, Rothwell E, Anderson RA, Goldenberg A, Kuppermann M, Dolan SM, Rose NC, Stark L. What parents want to know about the storage and use of residual newborn bloodspots. Am J Med Genet A. 2014 Nov;164A(11):2739-44. doi: 10.1002/ajmg.a.36694. Epub 2014 Aug 4.

Reference Type RESULT
PMID: 25131714 (View on PubMed)

Botkin JR, Rothwell E, Anderson RA, Rose NC, Dolan SM, Kuppermann M, Stark LA, Goldenberg A, Wong B. Prenatal Education of Parents About Newborn Screening and Residual Dried Blood Spots: A Randomized Clinical Trial. JAMA Pediatr. 2016 Jun 1;170(6):543-9. doi: 10.1001/jamapediatrics.2015.4850.

Reference Type DERIVED
PMID: 27043416 (View on PubMed)

Other Identifiers

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R01HG006266

Identifier Type: NIH

Identifier Source: secondary_id

View Link

IRB_00060088

Identifier Type: -

Identifier Source: org_study_id

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