TRIple in Asthma hiGh strenGth vErsus Ics/Laba hs and tiotRopium (TRIGGER)

NCT ID: NCT02676089

Last Updated: 2021-04-08

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE3
• Total Enrollment: 1433 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-04-06
• Study Completion Date: 2018-05-28

Brief Summary

The purpose of this study is to evaluate the superiority of CHF 5993 200/6/12.5 µg pMDI (fixed combination of extrafine beclometasone dipropionate plus formoterol fumarate plus glycopyrronium bromide) versus CHF 1535 200/6 µg pMDI (fixed combination of extrafine beclometasone dipropionate plus formoterol fumarate) and to compare the effect of CHF 5993 200/6/12.5 µg pMDI vs CHF 5993 200/6/12.5 µg plus open-label Tiotropium 2.5µg, in terms of lung functions parameters and rate of exacerbations, as well as to assess its safety and some health economics outcomes.

Conditions

Asthma

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

CHF 5993 200/6/12.5 µg

Treatment A:

CHF 5993 200/6/12.5 µg: 2 inhalations bid Total daily dose: 800/24/50 µg BDP/FF/GB

Group Type: EXPERIMENTAL

CHF 5993 200/6/12.5 µg

Intervention Type: DRUG

CHF 1535 200/6 µg

Treatment B:

CHF 1535 200/6 µg: 2 inhalations bid Total daily dose: 800/24 µg BDP/FF

Group Type: ACTIVE_COMPARATOR

CHF 1535 200/6 µg

Intervention Type: DRUG

CHF 1535 200/6 µg + Tiotropium Respimat 2.5 µg

Treatment C (open-label arm):

CHF 1535 200/6 µg: 2 inhalations bid

+ Tiotropium Respimat 2.5 µg: 2 inhalations od Total daily dose: 800/24 µg BDP/FF + 5 µg Tio

Group Type: ACTIVE_COMPARATOR

CHF 1535 200/6 µg + Tiotropium Respimat 2.5 µg

Intervention Type: DRUG

Interventions

CHF 5993 200/6/12.5 µg

Intervention Type: DRUG

CHF 1535 200/6 µg

Intervention Type: DRUG

CHF 1535 200/6 µg + Tiotropium Respimat 2.5 µg

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• History of asthma ≥ 1 year and diagnosed before 40 years old
• Uncontrolled asthma with double therapy only on high doses of Inhaled CorticoSteroid (ICS) in combination with Long-Acting Beta2 Agonist (LABA) with ACQ-7 (Asthma Control Questionnaire) ≥1.5
• Pre-bronchodilator FEV1 <80% of the predicted normal value
• Positive reversibility test
• At least 1 documented asthma exacerbation in the previous year

Exclusion Criteria

• Pregnant or lactating women
• Diagnosis of Chronic Obstructive Pulmonary Disease (COPD)
• Patients with any asthma exacerbation or respiratory tract infection in the 4 weeks prior screening
• Current smoker or ex-smoker (>= 10 packs year)
• Any change in dose, schedule or formulation of ICS + LABA combination in the 4 weeks prior screening

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Chiesi Farmaceutici S.p.A.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Georgio Walter Canonica, MD

Role: PRINCIPAL_INVESTIGATOR

University of Medicine, Genoa, Italy

Locations

Chiesi Clinical Trial Site 432702

Buenos Aires, , Argentina

Chiesi Clinical Trial Site 432704

CABA, , Argentina

Chiesi Clinical Trial Site 432705

Mar del Plata, , Argentina

Chiesi Clinical Trial Site 432701

Quilmes, , Argentina

Chiesi Clinical Trial Site 432703

San Miguel de Tucumán, , Argentina

Chiesi Clinical Trial Site 432706

San Miguel de Tucumán, , Argentina

Chiesi Clinical Trial Site 112703

Homyel, , Belarus

Chiesi Clinical Trial Site 112704

Homyel, , Belarus

Chiesi Clinical Trial Site 112701

Minsk, , Belarus

Chiesi Clinical Trial Site 112702

Minsk, , Belarus

Chiesi Clinical Trial Site 112705

Minsk, , Belarus

Chiesi Clinical Trial Site 100707

Blagoevgrad, , Bulgaria

Chiesi Clinical Trial Site 100720

Burgas, , Bulgaria

Chiesi Clinical Trial Site 100718

Gabrovo, , Bulgaria

Chiesi Clinical Trial Site 100713

Haskovo, , Bulgaria

Chiesi Clinical Trial Site 100722

Montana, , Bulgaria

Chiesi Clinical Trial Site 100702

Pleven, , Bulgaria

Chiesi Clinical Trial Site 100705

Plovdiv, , Bulgaria

Chiesi Clinical Trial Site 100708

Plovdiv, , Bulgaria

Chiesi Clinical Trial Site 100715

Plovdiv, , Bulgaria

Chiesi Clinical Trial Site 100716

Rousse, , Bulgaria

Chiesi Clinical Trial Site 100701

Sofia, , Bulgaria

Chiesi Clinical Trial Site 100703

Sofia, , Bulgaria

Chiesi Clinical Trial Site 100704

Sofia, , Bulgaria

Chiesi Clinical Trial Site 100709

Sofia, , Bulgaria

Chiesi Clinical Trial Site 100719

Sofia, , Bulgaria

Chiesi Clinical Trial Site 100706

Stara Zagora, , Bulgaria

Chiesi Clinical Trial Site 100712

Stara Zagora, , Bulgaria

Chiesi Clinical Trial Site 100710

Varna, , Bulgaria

Chiesi Clinical Trial Site 100711

Vidin, , Bulgaria

Chiesi Clinical Trial Site 100721

Vidin, , Bulgaria

Chiesi Clinical Trial Site 203711

Blansko, , Czechia

Chiesi Clinical Trial Site 203702

Brandýs nad Labem, , Czechia

Chiesi Clinical Trial Site 203708

Brno, , Czechia

Chiesi Clinical Trial Site 203707

Jindřichův Hradec, , Czechia

Chiesi Clinical Trial Site 203705

Kralupy nad Vltavou, , Czechia

Chiesi Clinical Trial Site 203709

Moravský Krumlov, , Czechia

Chiesi Clinical Trial Site 203704

Opava, , Czechia

Chiesi Clinical Trial Site 203701

Prague, , Czechia

Chiesi Clinical Trial Site 203703

Prague, , Czechia

Chiesi Clinical Trial Site 203710

Prague, , Czechia

Chiesi Clinical Trial Site 203713

Rokycany, , Czechia

Chiesi Clinical Trial Site 203706

Teplice, , Czechia

Chiesi Clinical Trial Site 203712

Varnsdorf, , Czechia

Chiesi Clinical Trial Site 276709

Berlin, , Germany

Chiesi Clinical Trial Site 276712

Berlin, , Germany

Chiesi Clinical Trial Site 276711

Bonn, , Germany

Chiesi Clinical Trial Site 276707

Frankfurt am Main, , Germany

Chiesi Clinical Trial Site 276714

Frankfurt am Main, , Germany

Chiesi Clinical Trial Site 276705

Hamburg, , Germany

Chiesi Clinical Trial Site 276703

Hanover, , Germany

Chiesi Clinical Trial Site 276708

Koblenz, , Germany

Chiesi Clinical Trial Site 276702

Leipzig, , Germany

Chiesi Clinical Trial Site 276704

Leipzig, , Germany

Chiesi Clinical Trial Site 276710

Leipzig, , Germany

Chiesi Clinical Trial Site 276715

Mainz, , Germany

Chiesi Clinical Trial Site 276701

München, , Germany

Chiesi Clinical Trial Site 276713

Münster, , Germany

Chiesi Clinical Trial Site 276716

Rosenheim, , Germany

Chiesi Clinical Trial Site 348707

Balassagyarmat, , Hungary

Chiesi Clinical Trial Site 348715

Budapest, , Hungary

Chiesi Clinical Trial Site 348721

Debrecen, , Hungary

Chiesi Clinical Trial Site 348708

Érd, , Hungary

Chiesi Clinical Trial Site 348712

Gödöllő, , Hungary

Chiesi Clinical Trial Site 348718

Hatvan, , Hungary

Chiesi Clinical Trial Site 348717

Komárom, , Hungary

Chiesi Clinical Trial Site 348709

Létavértes, , Hungary

Chiesi Clinical Trial Site 348703

Monor, , Hungary

Chiesi Clinical Trial Site 348719

Mórahalom, , Hungary

Chiesi Clinical Trial Site 348704

Nyíregyháza, , Hungary

Chiesi Clinical Trial Site 348714

Nyíregyháza, , Hungary

Chiesi Clinical Trial Site 348713

Pécs, , Hungary

Chiesi Clinical Trial Site 348702

Siófok, , Hungary

Chiesi Clinical Trial Site 348706

Szarvas, , Hungary

Chiesi Clinical Trial Site 348701

Szeged, , Hungary

Chiesi Clinical Trial Site 348705

Szentgotthárd, , Hungary

Chiesi Clinical Trial Site 348710

Vásárosnamény, , Hungary

Chiesi Clinical Trial Site 348720

Vecsés, , Hungary

Chiesi Clinical Trial Site 380704

Bologna, , Italy

Chiesi Clinical Trial Site 380703

Catania, , Italy

Chiesi Clinical Trial Site 380701

Genova, , Italy

Chiesi Clinical Trial Site 380705

Palermo, , Italy

Chiesi Clinical Trial Site 380702

Pavia, , Italy

Chiesi Clinical Trial Site 380706

Tradate, , Italy

Chiesi Clinical Trial Site 440701

Šiauliai, , Lithuania

Chiesi Clinical Trial Site 440702

Vilnius, , Lithuania

Chiesi Clinical Trial Site 440703

Vilnius, , Lithuania

Chiesi Clinical Trial Site 440705

Vilnius, , Lithuania

Chiesi Clinical Trial Site 616713

Bialystok, , Poland

Chiesi Clinical Trial Site 616718

Bialystok, , Poland

Chiesi Clinical Trial Site 616722

Bielsko-Biala, , Poland

Chiesi Clinical Trial Site 616702

Bienkówka, , Poland

Chiesi Clinical Trial Site 616727

Bydgoszcz, , Poland

Chiesi Clinical Trial Site 616701

Gdansk, , Poland

Chiesi Clinical Trial Site 616704

Giżycko, , Poland

Chiesi Clinical Trial Site 616716

Grudziądz, , Poland

Chiesi Clinical Trial Site 616725

Katowice, , Poland

Chiesi Clinical Trial Site 616729

Katowice, , Poland

Chiesi Clinical Trial Site 616719

Krakow, , Poland

Chiesi Clinical Trial Site 616734

Krakow, , Poland

Chiesi Clinical Trial Site 616736

Krakow, , Poland

Chiesi Clinical Trial Site 616707

Lodz, , Poland

Chiesi Clinical Trial Site 616708

Lodz, , Poland

Chiesi Clinical Trial Site 616711

Lodz, , Poland

Chiesi Clinical Trial Site 616726

Lodz, , Poland

Chiesi Clinical Trial Site 616733

Mrozy, , Poland

Chiesi Clinical Trial Site 616717

Ostróda, , Poland

Chiesi Clinical Trial Site 616731

Otwock, , Poland

Chiesi Clinical Trial Site 616703

Pabianice, , Poland

Chiesi Clinical Trial Site 616709

Poznan, , Poland

Chiesi Clinical Trial Site 616728

Poznan, , Poland

Chiesi Clinical Trial Site 616720

Proszowice, , Poland

Chiesi Clinical Trial Site 616723

Rzeszów, , Poland

Chiesi Clinical Trial Site 616735

Rzeszów, , Poland

Chiesi Clinical Trial Site 616721

Skierniewice, , Poland

Chiesi Clinical Trial Site 616732

Strzelce Opolskie, , Poland

Chiesi Clinical Trial Site 616712

Świdnik, , Poland

Chiesi Clinical Trial Site 616710

Tarnów, , Poland

Chiesi Clinical Trial Site 616730

Wilkowice, , Poland

Chiesi Clinical Trial Site 616705

Wroclaw, , Poland

Chiesi Clinical Trial Site 616714

Wroclaw, , Poland

Chiesi Clinical Trial Site 616715

Wroclaw, , Poland

Chiesi Clinical Trial Site 620704

Aveiro, , Portugal

Chiesi Clinical Trial Site 620703

Figueira da Foz Municipality, , Portugal

Chiesi Clinical Trial Site 620702

Lisbon, , Portugal

Chiesi Clinical Trial Site 620708

Loures, , Portugal

Chiesi Clinical Trial Site 620707

Vila Nova de Gaia, , Portugal

Chiesi Clinical Trial Site 642715

Alexandru cel Bun, , Romania

Chiesi Clinical Trial Site 642713

Arad, , Romania

Chiesi Clinical Trial Site 642722

Bacau, , Romania

Chiesi Clinical Trial Site 642717

Bragadiru, , Romania

Chiesi Clinical Trial Site 642706

Brasov, , Romania

Chiesi Clinical Trial Site 642703

Bucharest, , Romania

Chiesi Clinical Trial Site 642707

Bucharest, , Romania

Chiesi Clinical Trial Site 642708

Bucharest, , Romania

Chiesi Clinical Trial Site 642719

Bucharest, , Romania

Chiesi Clinical Trial Site 642723

Bucharest, , Romania

Chiesi Clinical Trial Site 642709

Cluj-Napoca, , Romania

Chiesi Clinical Trial Site 642714

Cluj-Napoca, , Romania

Chiesi Clinical Trial Site 642716

Cluj-Napoca, , Romania

Chiesi Clinical Trial Site 642718

Cluj-Napoca, , Romania

Chiesi Clinical Trial Site 642726

Cluj-Napoca, , Romania

Chiesi Clinical Trial Site 642712

Craiova, , Romania

Chiesi Clinical Trial Site 642704

Iași, , Romania

Chiesi Clinical Trial Site 642710

Iași, , Romania

Chiesi Clinical Trial Site 642705

Oradea, , Romania

Chiesi Clinical Trial Site 642711

Suceava, , Romania

Chiesi Clinical Trial Site 642721

Timișoara, , Romania

Chiesi Clinical Trial Site 643724

Anton, , Russia

Chiesi Clinical Trial Site 643727

Chelyabinsk, , Russia

Chiesi Clinical Trial Site 643733

Chelyabinsk, , Russia

Chiesi Clinical Trial Site 643745

Chelyabinsk, , Russia

Chiesi Clinical Trial Site 643754

Izhevsk, , Russia

Chiesi Clinical Trial Site 643713

Kazan', , Russia

Chiesi Clinical Trial Site 643719

Kazan', , Russia

Chiesi Clinical Trial Site 643741

Kazan', , Russia

Chiesi Clinical Trial Site 643746

Kazan', , Russia

Chiesi Clinical Trial Site 643704

Kemerovo, , Russia

Chiesi Clinical Trial Site 643731

Kemerovo, , Russia

Chiesi Clinical Trial Site 643702

Moscow, , Russia

Chiesi Clinical Trial Site 643705

Moscow, , Russia

Chiesi Clinical Trial Site 643706

Moscow, , Russia

Chiesi Clinical Trial Site 643718

Moscow, , Russia

Chiesi Clinical Trial Site 643722

Moscow, , Russia

Chiesi Clinical Trial Site 643735

Moscow, , Russia

Chiesi Clinical Trial Site 643743

Moscow, , Russia

Chiesi Clinical Trial Site 643707

Nizhny Novgorod, , Russia

Chiesi Clinical Trial Site 643723

Nizhny Novgorod, , Russia

Chiesi Clinical Trial Site 643744

Nizhny Novgorod, , Russia

Chiesi Clinical Trial Site 643717

Novosibirsk, , Russia

Chiesi Clinical Trial Site 643729

Orenburg, , Russia

Chiesi Clinical Trial Site 643711

Pyatigorsk, , Russia

Chiesi Clinical Trial Site 643701

Ryazan, , Russia

Chiesi Clinical Trial Site 643712

Saint Petersburg, , Russia

Chiesi Clinical Trial Site 643714

Saint Petersburg, , Russia

Chiesi Clinical Trial Site 643715

Saint Petersburg, , Russia

Chiesi Clinical Trial Site 643716

Saint Petersburg, , Russia

Chiesi Clinical Trial Site 643725

Saint Petersburg, , Russia

Chiesi Clinical Trial Site 643730

Saint Petersburg, , Russia

Chiesi Clinical Trial Site 643732

Saint Petersburg, , Russia

Chiesi Clinical Trial Site 643737

Saint Petersburg, , Russia

Chiesi Clinical Trial Site 643739

Saint Petersburg, , Russia

Chiesi Clinical Trial Site 643752

Saint Petersburg, , Russia

Chiesi Clinical Trial Site 643757

Saint Petersburg, , Russia

Chiesi Clinical Trial Site 643758

Saint Petersburg, , Russia

Chiesi Clinical Trial Site 643703

Saratov, , Russia

Chiesi Clinical Trial Site 643736

Saratov, , Russia

Chiesi Clinical Trial Site 643726

Smolensk, , Russia

Chiesi Clinical Trial Site 643740

Stavropol, , Russia

Chiesi Clinical Trial Site 643709

Tomsk, , Russia

Chiesi Clinical Trial Site 643728

Tomsk, , Russia

Chiesi Clinical Trial Site 643759

Tomsk, , Russia

Chiesi Clinical Trial Site 643755

Ufa, , Russia

Chiesi Clinical Trial Site 643708

Vladikavkaz, , Russia

Chiesi Clinical Trial Site 643738

Vladimir, , Russia

Chiesi Clinical Trial Site 643710

Voronezh, , Russia

Chiesi Clinical Trial Site 643720

Yaroslavl, , Russia

Chiesi Clinical Trial Site 643734

Yaroslavl, , Russia

Chiesi Clinical Trial Site 643742

Yaroslavl, , Russia

Chiesi Clinical Trial Site 643749

Yaroslavl, , Russia

Chiesi Clinical Trial Site 643721

Yekaterinburg, , Russia

Chiesi Clinical Trial Site 703704

Bratislava, , Slovakia

Chiesi Clinical Trial Site 703707

Bratislava, , Slovakia

Chiesi Clinical Trial Site 703702

Ilava, , Slovakia

Chiesi Clinical Trial Site 703705

Košice, , Slovakia

Chiesi Clinical Trial Site 703706

Košice, , Slovakia

Chiesi Clinical Trial Site 703701

Nové Zámky, , Slovakia

Chiesi Clinical Trial Site 703709

Prievidza, , Slovakia

Chiesi Clinical Trial Site 703703

Spišská Nová Ves, , Slovakia

Chiesi Clinical Trial Site 703708

Štúrovo, , Slovakia

Chiesi Clinical Trial Site 724702

A Coruña, , Spain

Chiesi Clinical Trial Site 724703

Badajoz, , Spain

Chiesi Clinical Trial Site 724706

Badalona, , Spain

Chiesi Clinical Trial Site 724701

Madrid, , Spain

Chiesi Clinical Trial Site 724704

Madrid, , Spain

Chiesi Clinical Trial Site 724705

Málaga, , Spain

Chiesi Clinical Trial Site 724707

Sabadell, , Spain

Chiesi Clinical Trial Site 792701

Ankara, , Turkey (Türkiye)

Chiesi Clinical Trial Site 792702

Ankara, , Turkey (Türkiye)

Chiesi Clinical Trial Site 792703

Antalya, , Turkey (Türkiye)

Chiesi Clinical Trial Site 792710

Aydin, , Turkey (Türkiye)

Chiesi Clinical Trial Site 792707

Istanbul, , Turkey (Türkiye)

Chiesi Clinical Trial Site 792706

Kocaeli, , Turkey (Türkiye)

Chiesi Clinical Trial Site 792705

Maltepe, , Turkey (Türkiye)

Chiesi Clinical Trial Site 792708

Mersin, , Turkey (Türkiye)

Chiesi Clinical Trial Site 792709

Yenişehir, , Turkey (Türkiye)

Chiesi Clinical Trial Site 804701

Dnipro, , Ukraine

Chiesi Clinical Trial Site 804711

Ivano-Frankivsk, , Ukraine

Chiesi Clinical Trial Site 804709

Kharkiv, , Ukraine

Chiesi Clinical Trial Site 804710

Kherson, , Ukraine

Chiesi Clinical Trial Site 804713

Kiev, , Ukraine

Chiesi Clinical Trial Site 804705

Kyiv, , Ukraine

Chiesi Clinical Trial Site 804712

Lviv, , Ukraine

Chiesi Clinical Trial Site 804715

Sumy, , Ukraine

Chiesi Clinical Trial Site 804703

Vinnytsia, , Ukraine

Chiesi Clinical Trial Site 804706

Vinnytsia, , Ukraine

Chiesi Clinical Trial Site 804707

Vinnytsia, , Ukraine

Chiesi Clinical Trial Site 804714

Vinnytsia, , Ukraine

Chiesi Clinical Trial Site 804704

Zaporizhzhya, , Ukraine

Chiesi Clinical Trial Site 804708

Zhytomyr, , Ukraine

Chiesi Clinical Trial Site 826702

Llanelli, , United Kingdom

Chiesi Clinical Trial Site 826703

London, , United Kingdom

Chiesi Clinical Trial Site 826704

Manchester, , United Kingdom

Chiesi Clinical Trial Site 826701

Soham, , United Kingdom

Countries

Argentina; Belarus; Bulgaria; Czechia; Germany; Hungary; Italy; Lithuania; Poland; Portugal; Romania; Russia; Slovakia; Spain; Turkey (Türkiye); Ukraine; United Kingdom

References

Virchow JC, Kuna P, Paggiaro P, Papi A, Singh D, Corre S, Zuccaro F, Vele A, Kots M, Georges G, Petruzzelli S, Canonica GW. Single inhaler extrafine triple therapy in uncontrolled asthma (TRIMARAN and TRIGGER): two double-blind, parallel-group, randomised, controlled phase 3 trials. Lancet. 2019 Nov 9;394(10210):1737-1749. doi: 10.1016/S0140-6736(19)32215-9. Epub 2019 Sep 30.

Reference Type: RESULT

PMID: 31582314 (View on PubMed)

Oba Y, Anwer S, Maduke T, Patel T, Dias S. Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying doses of inhaled corticosteroids in adolescents and adults with asthma: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2022 Dec 6;12(12):CD013799. doi: 10.1002/14651858.CD013799.pub2.

Reference Type: DERIVED

PMID: 36472162 (View on PubMed)

Orlovic M, Magni T, Lukyanov V, Guerra I, Madoni A. Cost-effectiveness of single-inhaler extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium in patients with uncontrolled asthma in England. Respir Med. 2022 Sep;201:106934. doi: 10.1016/j.rmed.2022.106934. Epub 2022 Jul 19.

Reference Type: DERIVED

PMID: 35872377 (View on PubMed)

Papi A, Singh D, Virchow JC, Canonica GW, Vele A, Georges G. Normalisation of airflow limitation in asthma: Post-hoc analyses of TRIMARAN and TRIGGER. Clin Transl Allergy. 2022 Apr 17;12(4):e12145. doi: 10.1002/clt2.12145. eCollection 2022 Apr.

Reference Type: DERIVED

PMID: 35450196 (View on PubMed)

Singh D, Virchow JC, Canonica GW, Vele A, Kots M, Georges G, Papi A. Determinants of response to inhaled extrafine triple therapy in asthma: analyses of TRIMARAN and TRIGGER. Respir Res. 2020 Oct 29;21(1):285. doi: 10.1186/s12931-020-01558-y.

Reference Type: DERIVED

PMID: 33121501 (View on PubMed)

Singh D, Virchow JC, Canonica GW, Vele A, Kots M, Georges G, Papi A. Extrafine triple therapy in patients with asthma and persistent airflow limitation. Eur Respir J. 2020 Sep 24;56(3):2000476. doi: 10.1183/13993003.00476-2020. Print 2020 Sep. No abstract available.

Reference Type: DERIVED

PMID: 32430414 (View on PubMed)

Related Links

https://www.clinicaltrialsregister.eu/ctr-search/trial/2015-000717-40/results

Study Record on EU Clinical Trials Register including results.

Other Identifiers

2015-000717-40

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

CCD-05993AB2-02

Identifier Type: -

Identifier Source: org_study_id