Impact of Tiotropium Add-on Therapy in Patients With Asthma

NCT ID: NCT03964220

Last Updated: 2020-11-03

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

7857 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-03-15

Study Completion Date

2019-09-20

Brief Summary

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To evaluate the effectiveness of add on therapy with Tiotropium Respimat® compared to increasing the dose of ICS in patients with a diagnosis of Asthma and on ICS/LABA therapy

Detailed Description

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Conditions

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Asthma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patients with Asthma

Tiotropium Respimat®

Intervention Type DRUG

Tiotropium Respimat® 1.25 mcg (on top of baseline Inhaled Corticosteroid/Long-acting beta-agonist )

Inhaled Corticosteroid/Long-acting beta-agonist

Intervention Type DRUG

baseline low dose to medium/high dose, baseline medium dose ICS/LABA to high dose ICS/LABA, additional prescription/refill of high-dose-ICS/LABA following the first prescription of baseline high dose ICS/LABA

Interventions

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Tiotropium Respimat®

Tiotropium Respimat® 1.25 mcg (on top of baseline Inhaled Corticosteroid/Long-acting beta-agonist )

Intervention Type DRUG

Inhaled Corticosteroid/Long-acting beta-agonist

baseline low dose to medium/high dose, baseline medium dose ICS/LABA to high dose ICS/LABA, additional prescription/refill of high-dose-ICS/LABA following the first prescription of baseline high dose ICS/LABA

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with least one asthma diagnosis in the inpatient setting or at least two separate instances of asthma diagnosis (separated by at least 30 days) recorded in the outpatient or emergency room setting will be included.
* Patients will be required to be already on Inhaled Corticosteroid/Long-acting beta-agonist (ICS/LABA).
* Patients will be required to have available records 12 months prior to the index date.

Exclusion Criteria

* Patients below the age of 6 years on the Inhaled Corticosteroid/Long-acting beta-agonist initiation (ICS/LABAi) date will be excluded.
* Patients with a diagnosis of COPD at any time during the study period will be excluded.
* Those who are on biologics at baseline will be removed.
* After the PSM process, unmatched patients will be excluded.
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boehringer Ingelheim

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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eMax Health

White Plains, New York, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Related Links

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Other Identifiers

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0205-0543

Identifier Type: -

Identifier Source: org_study_id