A Multi-Institutional Pilot Study of Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Malignant Neuro-Epithelial and Other Solid Tumors

NCT ID: NCT02653196

Last Updated: 2017-08-17

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: EARLY_PHASE1
• Total Enrollment: 1 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-09-30
• Study Completion Date: 2017-08-31

Brief Summary

There is currently no standard treatment for patients with neuro-epithelial (brain) or other solid tumors in another part of the body who do not have adequate suitable autologous hematopoietic progenitor cells available and/or whose disease has relapsed after standard treatment. Allogeneic Hematopoietic Progenitor Cell Transplant may be a consideration for treatment of patients with recurrent chemo-responsive malignant (high grade) neuro-epithelial and other solid tumors or those who do not have suitable autologous hematopoietic progenitor cell availability. The procedure in which your own blood stem cells are transplanted to you is called an autologous (from your own) progenitor cell transplant and when cells from a matched donor are transfused is called an allogeneic progenitor cell transplant. The study is being conducted to evaluate the safety and effectiveness of a combination of drugs followed by an allogeneic hematopoietic progenitor cell transplant (HPCT). This treatment regimen is experimental in that although the individual drugs are commonly used to treat your disease, the specific combination used in this protocol followed by the transplant is experimental.

Detailed Description

This is a multi-institutional Pilot clinical trial of hematopoietic stem cell transplantation (HSCT) for (i) patients with recurrent chemo-responsive malignant (high-grade) neuro-epithelial and other solid tumors which are recurrent following HSCT or (ii) for said patients without autologous hematopoietic progenitor cell availability. The stem cells will be derived from a 1) matched related donor or 2) matched unrelated donor (MUD).

This is a pilot study of a novel HSCT protocol for patients with high-grade and/or recurrent neuro-epithelial and other solid tumors. To determine the feasibility of allogeneic HSCT following thiotepa-based marrow ablative chemotherapy (MAC) for children with high-grade and/or recurrent neuro-epithelial and other solid tumors. The primary end-point for this study is to determine progression-free survival (PFS) at six months post-HSCT. Secondary end-points include: (a) overall survival (OS) at one year (b) transplant related mortality (TRM) at Day +100 (c) engraftment (d) regimen related toxicity: the frequency and severity of acute and chronic graft-versus-host disease (GVHD), sinusoidal obstructive syndrome and infections will be assessed (e) time to immune reconstitution following HSCT. Exploratory Aims include: 1) To assess the feasibility of the Taqman® Low Density Arrays (TLDA) assay as a technology for MRD detection among a subset of patients with high-grade and/or recurrent neuro-epithelial and other solid tumors. Minimal residual disease (MRD) (when applicable) in bone marrow pre- and post-HSCT, will be assessed using TLDA. Currently, for solid malignancies there is no routinely established method to detect minimal residual disease, the first indicator of therapy failure and/or recurrence of disease. 2) In an effort to minimize morbidity related to graft-versus-host disease, alemtuzumab forms an important component of the proposed MAC regimen for recipients of unrelated or related mismatched allogeneic grafts. As an exploratory aim, an alemtuzumab assay will be performed at specified intervals to explore time to drug clearance. This may provide important information regarding lymphodepletion for future trials regarding immunotherapy administered during recovery from HSCT therapy.

The main advantages of the proposed approach will: 1) Overcome the challenges in bone morrow/peripheral blood stem cell (PBSC) collection in patients heavily pre-treated and/or bone/bone marrow infiltration with tumor. 2) Eliminate the risk of graft contamination with tumor cells, and 3) Graft-versus-tumor effect (GVT) to eliminate residual disease after conditioning chemotherapy. The use of allografting with the proposed regimen combines the benefits of high dose chemotherapy and an immune approach to disease therapy.

Conditions

Neuroepithelial Tumor; Solid Tumor; Allogeneic Hematopoietic Stem Cell Transplantation

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Allogeneic Hematopoietic Stem Cell Transplant

Matched Unrelated Donor HSCT (minimum 9/10 human leukocyte antigen [HLA] match) OR Matched Related Donor HSCT (10/10 HLA match). Conditioning regimen begins 12 days prior to stem cell infusion and includes the following drugs:

Keratinocyte Growth Factor Alemtuzumab Thiotepa Etoposide Melphalan Fludarabine Tacrolimus (Cyclosporine A may be substituted for Tacrolimus) Mycophenolate mofetil

Group Type: EXPERIMENTAL

Allogeneic hematopoietic stem cell transplant following thiotepa-based marrow ablative chemotherapy

Intervention Type: PROCEDURE

Allogeneic hematopoietic stem cell transplant (HSCT) following thiotepa-based marrow ablative chemotherapy (MAC) for children with high-grade and/or recurrent neuro-epithelial and other solid tumors.

Keratinocyte Growth Factor

Intervention Type: DRUG

KGF 60 mcg/kg IV: 6 doses

Alemtuzumab

Intervention Type: DRUG

Alemtuzumab 12 mg/m2 IV: 2 doses (not given if matched related donor is 10/10 HLA matched sibling donor)

Thiotepa

Intervention Type: DRUG

Thiotepa 300 mg/m2 IV: 3 doses

Etoposide

Intervention Type: DRUG

Etoposide 100 mg/m2 IV: 3 doses

Fludarabine

Intervention Type: DRUG

Fludarabine 30 mg/m2 IV: 3 doses

Melphalan

Intervention Type: DRUG

Melphalan 70 mg/m2 IV: Day 2 doses

Tacrolimus

Intervention Type: DRUG

Tacrolimus 0.05 mg/kg/day IV (Cyclosporine may be substituted for Tacrolimus): Start Day -2, begin taper on Day +100, discontinue on Day +180

Cyclosporine A

Intervention Type: DRUG

Cyclosporine A dosed as follows: Age ≤ 6 years: 6 mg/kg/day IV in divided doses (e.g. 2 mg/kg every 8 hours) OR Age \> 6 years: 3 mg/kg/day IV in divided doses (1.5 mg/kg every 12 hours): Start Day -2, begin taper on Day +100, discontinue on Day +180

Mycophenolate mofetil

Intervention Type: DRUG

Mycophenolate mofetil 15 mg/kg every 8 hours oral or IV: Start Day 0 (4-6 hours post stem cell infusion) to Day +40, then taper weekly until discontinuation on Day +90

Interventions

Allogeneic hematopoietic stem cell transplant following thiotepa-based marrow ablative chemotherapy

Allogeneic hematopoietic stem cell transplant (HSCT) following thiotepa-based marrow ablative chemotherapy (MAC) for children with high-grade and/or recurrent neuro-epithelial and other solid tumors.

Intervention Type: PROCEDURE

Keratinocyte Growth Factor

KGF 60 mcg/kg IV: 6 doses

Intervention Type: DRUG

Alemtuzumab

Alemtuzumab 12 mg/m2 IV: 2 doses (not given if matched related donor is 10/10 HLA matched sibling donor)

Intervention Type: DRUG

Thiotepa

Thiotepa 300 mg/m2 IV: 3 doses

Intervention Type: DRUG

Etoposide

Etoposide 100 mg/m2 IV: 3 doses

Intervention Type: DRUG

Fludarabine

Fludarabine 30 mg/m2 IV: 3 doses

Intervention Type: DRUG

Melphalan

Melphalan 70 mg/m2 IV: Day 2 doses

Intervention Type: DRUG

Tacrolimus

Tacrolimus 0.05 mg/kg/day IV (Cyclosporine may be substituted for Tacrolimus): Start Day -2, begin taper on Day +100, discontinue on Day +180

Intervention Type: DRUG

Cyclosporine A

Cyclosporine A dosed as follows: Age ≤ 6 years: 6 mg/kg/day IV in divided doses (e.g. 2 mg/kg every 8 hours) OR Age \> 6 years: 3 mg/kg/day IV in divided doses (1.5 mg/kg every 12 hours): Start Day -2, begin taper on Day +100, discontinue on Day +180

Intervention Type: DRUG

Mycophenolate mofetil

Mycophenolate mofetil 15 mg/kg every 8 hours oral or IV: Start Day 0 (4-6 hours post stem cell infusion) to Day +40, then taper weekly until discontinuation on Day +90

Intervention Type: DRUG

Other Intervention Names

KGF; Kepivance; Palifermin; Campath; Campath 1H; VP-16; FLUDARA; Cyclosporine; CYA; CSA; Sandimmune; Neoral; Gengraf; MMF; Cellcept; Myfortic

Eligibility Criteria

Inclusion Criteria

• Malignant (high-grade) neuro-epithelial and other solid tumors
• Patients have to be in at least, a chemo-responsive disease status defined as; any disease regression to chemotherapy when compared to its pre-treatment evaluation
• Patients with recurrent (or refractory) chemo-responsive disease or without suitable autologous hematopoietic progenitor cell availability
• Creatinine clearance or glomerular filtration rate (GFR) ≥50 ml/min/1.73m2, and not requiring dialysis
• Diffusing capacity of lung for carbon monoxide, or DLCO, (corrected for hemoglobin) ≥ 50% predicted. If unable to perform pulmonary function tests, then oxygen (O2) saturation ≥ 92% in room air
• Bilirubin ≤3x upper limit of normal (ULN) and alanine transaminase (ALT) and aspartate transaminase (AST) ≤ 5x for age (with the exception of isolated hyperbilirubinemia due to Gilbert's syndrome)

Exclusion Criteria

• Lack of histocompatible suitable related or unrelated donor/ graft source
• End-organ failure that precludes the ability to tolerate the transplant procedure, including conditioning
• Renal failure requiring dialysis
• Congenital heart disease resulting in congestive heart failure
• Ventilatory failure
• HIV infection
• Female of reproductive potential who is pregnant, planning to become pregnant during the study, or is nursing a child

• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Children's Hospital Los Angeles

OTHER

Sponsor Role: collaborator

Nationwide Children's Hospital

OTHER

Sponsor Role: collaborator

Montefiore Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Kris M. Mahadeo

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Kris M Mahadeo, MD,MPH

Role: PRINCIPAL_INVESTIGATOR

The Children's Hospital at Montefiore

Locations

The Children's Hospital at Montefiore

The Bronx, New York, United States

Countries

United States

References

Smith MA, Seibel NL, Altekruse SF, Ries LA, Melbert DL, O'Leary M, Smith FO, Reaman GH. Outcomes for children and adolescents with cancer: challenges for the twenty-first century. J Clin Oncol. 2010 May 20;28(15):2625-34. doi: 10.1200/JCO.2009.27.0421. Epub 2010 Apr 19.

Reference Type: BACKGROUND

PMID: 20404250 (View on PubMed)

Chow KH, Gottschalk S. Cellular immunotherapy for high-grade glioma. Immunotherapy. 2011 Mar;3(3):423-34. doi: 10.2217/imt.10.110.

Reference Type: BACKGROUND

PMID: 21395383 (View on PubMed)

Daniels BP, Cruz-Orengo L, Pasieka TJ, Couraud PO, Romero IA, Weksler B, Cooper JA, Doering TL, Klein RS. Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier. J Neurosci Methods. 2013 Jan 15;212(1):173-9. doi: 10.1016/j.jneumeth.2012.10.001. Epub 2012 Oct 13.

Reference Type: BACKGROUND

PMID: 23068604 (View on PubMed)

Mitchell DA, Fecci PE, Sampson JH. Immunotherapy of malignant brain tumors. Immunol Rev. 2008 Apr;222:70-100. doi: 10.1111/j.1600-065X.2008.00603.x.

Reference Type: BACKGROUND

PMID: 18363995 (View on PubMed)

Packer RJ, Gajjar A, Vezina G, Rorke-Adams L, Burger PC, Robertson PL, Bayer L, LaFond D, Donahue BR, Marymont MH, Muraszko K, Langston J, Sposto R. Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol. 2006 Sep 1;24(25):4202-8. doi: 10.1200/JCO.2006.06.4980.

Reference Type: BACKGROUND

PMID: 16943538 (View on PubMed)

Finlay JL, Goldman S, Wong MC, Cairo M, Garvin J, August C, Cohen BH, Stanley P, Zimmerman RA, Bostrom B, Geyer JR, Harris RE, Sanders J, Yates AJ, Boyett JM, Packer RJ. Pilot study of high-dose thiotepa and etoposide with autologous bone marrow rescue in children and young adults with recurrent CNS tumors. The Children's Cancer Group. J Clin Oncol. 1996 Sep;14(9):2495-503. doi: 10.1200/JCO.1996.14.9.2495.

Reference Type: BACKGROUND

PMID: 8823328 (View on PubMed)

Sung KW, Yoo KH, Cho EJ, Koo HH, Lim DH, Shin HJ, Ahn SD, Ra YS, Choi ES, Ghim TT. High-dose chemotherapy and autologous stem cell rescue in children with newly diagnosed high-risk or relapsed medulloblastoma or supratentorial primitive neuroectodermal tumor. Pediatr Blood Cancer. 2007 Apr;48(4):408-15. doi: 10.1002/pbc.21064.

Reference Type: BACKGROUND

PMID: 17066462 (View on PubMed)

Ris MD, Packer R, Goldwein J, Jones-Wallace D, Boyett JM. Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a Children's Cancer Group study. J Clin Oncol. 2001 Aug 1;19(15):3470-6. doi: 10.1200/JCO.2001.19.15.3470.

Reference Type: BACKGROUND

PMID: 11481352 (View on PubMed)

Henon PR, Butturini A, Gale RP. Blood-derived haematopoietic cell transplants: blood to blood? Lancet. 1991 Apr 20;337(8747):961-3. doi: 10.1016/0140-6736(91)91583-g. No abstract available.

Reference Type: BACKGROUND

PMID: 1678042 (View on PubMed)

Mason WP, Grovas A, Halpern S, Dunkel IJ, Garvin J, Heller G, Rosenblum M, Gardner S, Lyden D, Sands S, Puccetti D, Lindsley K, Merchant TE, O'Malley B, Bayer L, Petriccione MM, Allen J, Finlay JL. Intensive chemotherapy and bone marrow rescue for young children with newly diagnosed malignant brain tumors. J Clin Oncol. 1998 Jan;16(1):210-21. doi: 10.1200/JCO.1998.16.1.210.

Reference Type: BACKGROUND

PMID: 9440745 (View on PubMed)

Shih CS, Hale GA, Gronewold L, Tong X, Laningham FH, Gilger EA, Srivastava DK, Kun LE, Gajjar A, Fouladi M. High-dose chemotherapy with autologous stem cell rescue for children with recurrent malignant brain tumors. Cancer. 2008 Mar 15;112(6):1345-53. doi: 10.1002/cncr.23305.

Reference Type: BACKGROUND

PMID: 18224664 (View on PubMed)

Gururangan S, Krauser J, Watral MA, Driscoll T, Larrier N, Reardon DA, Rich JN, Quinn JA, Vredenburgh JJ, Desjardins A, McLendon RE, Fuchs H, Kurtzberg J, Friedman HS. Efficacy of high-dose chemotherapy or standard salvage therapy in patients with recurrent medulloblastoma. Neuro Oncol. 2008 Oct;10(5):745-51. doi: 10.1215/15228517-2008-044. Epub 2008 Aug 28.

Reference Type: BACKGROUND

PMID: 18755919 (View on PubMed)

Butturini AM, Jacob M, Aguajo J, Vander-Walde NA, Villablanca J, Jubran R, Erdreich-Epstein A, Marachelian A, Dhall G, Finlay JL. High-dose chemotherapy and autologous hematopoietic progenitor cell rescue in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors: the impact of prior radiotherapy on outcome. Cancer. 2009 Jul 1;115(13):2956-63. doi: 10.1002/cncr.24341.

Reference Type: BACKGROUND

PMID: 19402050 (View on PubMed)

Lundberg JH, Weissman DE, Beatty PA, Ash RC. Treatment of recurrent metastatic medulloblastoma with intensive chemotherapy and allogeneic bone marrow transplantation. J Neurooncol. 1992 Jun;13(2):151-5. doi: 10.1007/BF00172764.

Reference Type: BACKGROUND

PMID: 1432032 (View on PubMed)

Secondino S, Pedrazzoli P, Schiavetto I, Basilico V, Bramerio E, Massimino M, Gambacorta M, Siena S. Antitumor effect of allogeneic hematopoietic SCT in metastatic medulloblastoma. Bone Marrow Transplant. 2008 Jul;42(2):131-3. doi: 10.1038/bmt.2008.86. Epub 2008 Mar 31. No abstract available.

Reference Type: BACKGROUND

PMID: 18372908 (View on PubMed)

Takada S, Ito K, Sakura T, Hatsumi N, Sato M, Saito T, Shiozaki H, Matsushima T, Miyawaki S. Three AML patients with existing or pre-existing intracerebral granulocytic sarcomas who were successfully treated with allogeneic bone marrow transplantations. Bone Marrow Transplant. 1999 Apr;23(7):731-4. doi: 10.1038/sj.bmt.1701635.

Reference Type: BACKGROUND

PMID: 10218852 (View on PubMed)

Kasow KA, Handgretinger R, Krasin MJ, Pappo AS, Leung W. Possible allogeneic graft-versus-tumor effect in childhood melanoma. J Pediatr Hematol Oncol. 2003 Dec;25(12):982-6. doi: 10.1097/00043426-200312000-00016.

Reference Type: BACKGROUND

PMID: 14663285 (View on PubMed)

Ueno NT, Cheng YC, Rondon G, Tannir NM, Gajewski JL, Couriel DR, Hosing C, de Lima MJ, Anderlini P, Khouri IF, Booser DJ, Hortobagyi GN, Pagliaro LC, Jonasch E, Giralt SA, Champlin RE. Rapid induction of complete donor chimerism by the use of a reduced-intensity conditioning regimen composed of fludarabine and melphalan in allogeneic stem cell transplantation for metastatic solid tumors. Blood. 2003 Nov 15;102(10):3829-36. doi: 10.1182/blood-2003-04-1022. Epub 2003 Jul 24.

Reference Type: BACKGROUND

PMID: 12881308 (View on PubMed)

Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A, Posati S, Rogaia D, Frassoni F, Aversa F, Martelli MF, Velardi A. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science. 2002 Mar 15;295(5562):2097-100. doi: 10.1126/science.1068440.

Reference Type: BACKGROUND

PMID: 11896281 (View on PubMed)

Venstrom JM, Zheng J, Noor N, Danis KE, Yeh AW, Cheung IY, Dupont B, O'Reilly RJ, Cheung NK, Hsu KC. KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma. Clin Cancer Res. 2009 Dec 1;15(23):7330-4. doi: 10.1158/1078-0432.CCR-09-1720. Epub 2009 Nov 24.

Reference Type: BACKGROUND

PMID: 19934297 (View on PubMed)

Aoyama Y, Yamamura R, Shima E, Nakamae H, Makita K, Kho G, Ohta K, Yamane T, Takubo T, Hino M. Successful treatment with reduced-intensity stem cell transplantation in a case of relapsed refractory central nervous system lymphoma. Ann Hematol. 2003 Jun;82(6):371-3. doi: 10.1007/s00277-003-0651-z. Epub 2003 Apr 29.

Reference Type: BACKGROUND

PMID: 12719887 (View on PubMed)

Varadi G, Or R, Kapelushnik J, Naparstek E, Nagler A, Brautbar C, Amar A, Kirschbaum M, Samuel S, Slavin S, Siegal T. Graft-versus-lymphoma effect after allogeneic peripheral blood stem cell transplantation for primary central nervous system lymphoma. Leuk Lymphoma. 1999 Jun;34(1-2):185-90. doi: 10.3109/10428199909083396.

Reference Type: BACKGROUND

PMID: 10350348 (View on PubMed)

Abdel-Azim H, Kapoor N, Mahadeo KM, Finlay JL. Graft versus tumor effect in the brain of a child with recurrent metastatic medulloblastoma. Pediatr Blood Cancer. 2015 Sep;62(9):1667-9. doi: 10.1002/pbc.25525. Epub 2015 Apr 20.

Reference Type: BACKGROUND

PMID: 25894457 (View on PubMed)

Ellman L, Katz DH, Green I, Paul WE, Benacerraf B. Mechanisms involved in the antileukemic effect of immunocompetent allogeneic lymphoid cell transfer. Cancer Res. 1972 Jan;32(1):141-8. No abstract available.

Reference Type: BACKGROUND

PMID: 4400015 (View on PubMed)

Symons HJ, Levy MY, Wang J, Zhou X, Zhou G, Cohen SE, Luznik L, Levitsky HI, Fuchs EJ. The allogeneic effect revisited: exogenous help for endogenous, tumor-specific T cells. Biol Blood Marrow Transplant. 2008 May;14(5):499-509. doi: 10.1016/j.bbmt.2008.02.013.

Reference Type: BACKGROUND

PMID: 18410892 (View on PubMed)

Maine GN, Mule JJ. Making room for T cells. J Clin Invest. 2002 Jul;110(2):157-9. doi: 10.1172/JCI16166. No abstract available.

Reference Type: BACKGROUND

PMID: 12122106 (View on PubMed)

Ahmed N, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels WS, Bhattacharjee MB, Gilbertson RJ, Shine HD, Weiss HL, Rooney CM, Heslop HE, Gottschalk S. Regression of experimental medulloblastoma following transfer of HER2-specific T cells. Cancer Res. 2007 Jun 15;67(12):5957-64. doi: 10.1158/0008-5472.CAN-06-4309.

Reference Type: BACKGROUND

PMID: 17575166 (View on PubMed)

Perez-Martinez A, de Prada Vicente I, Fernandez L, Gonzalez-Vicent M, Valentin J, Martin R, Maxwell H, Sevilla J, Vicario JL, Diaz MA. Natural killer cells can exert a graft-vs-tumor effect in haploidentical stem cell transplantation for pediatric solid tumors. Exp Hematol. 2012 Nov;40(11):882-891.e1. doi: 10.1016/j.exphem.2012.07.004. Epub 2012 Jul 4.

Reference Type: BACKGROUND

PMID: 22771496 (View on PubMed)

Ash S, Gigi V, Askenasy N, Fabian I, Stein J, Yaniv I. Graft versus neuroblastoma reaction is efficiently elicited by allogeneic bone marrow transplantation through cytolytic activity in the absence of GVHD. Cancer Immunol Immunother. 2009 Dec;58(12):2073-84. doi: 10.1007/s00262-009-0715-6. Epub 2009 May 13.

Reference Type: BACKGROUND

PMID: 19437016 (View on PubMed)

Lang P, Pfeiffer M, Muller I, Schumm M, Ebinger M, Koscielniak E, Feuchtinger T, Foll J, Martin D, Handgretinger R. Haploidentical stem cell transplantation in patients with pediatric solid tumors: preliminary results of a pilot study and analysis of graft versus tumor effects. Klin Padiatr. 2006 Nov-Dec;218(6):321-6. doi: 10.1055/s-2006-942256.

Reference Type: BACKGROUND

PMID: 17080334 (View on PubMed)

Jubert C, Wall DA, Grimley M, Champagne MA, Duval M. Engraftment of unrelated cord blood after reduced-intensity conditioning regimen in children with refractory neuroblastoma: a feasibility trial. Bone Marrow Transplant. 2011 Feb;46(2):232-7. doi: 10.1038/bmt.2010.107. Epub 2010 May 3.

Reference Type: BACKGROUND

PMID: 20436519 (View on PubMed)

Koscielniak E, Gross-Wieltsch U, Treuner J, Winkler P, Klingebiel T, Lang P, Bader P, Niethammer D, Handgretinger R. Graft-versus-Ewing sarcoma effect and long-term remission induced by haploidentical stem-cell transplantation in a patient with relapse of metastatic disease. J Clin Oncol. 2005 Jan 1;23(1):242-4. doi: 10.1200/JCO.2005.05.940. No abstract available.

Reference Type: BACKGROUND

PMID: 15625381 (View on PubMed)

Burdach S, van Kaick B, Laws HJ, Ahrens S, Haase R, Korholz D, Pape H, Dunst J, Kahn T, Willers R, Engel B, Dirksen U, Kramm C, Nurnberger W, Heyll A, Ladenstein R, Gadner H, Jurgens H, Go el U. Allogeneic and autologous stem-cell transplantation in advanced Ewing tumors. An update after long-term follow-up from two centers of the European Intergroup study EICESS. Stem-Cell Transplant Programs at Dusseldorf University Medical Center, Germany and St. Anna Kinderspital, Vienna, Austria. Ann Oncol. 2000 Nov;11(11):1451-62. doi: 10.1023/a:1026539908115.

Reference Type: BACKGROUND

PMID: 11142486 (View on PubMed)

Burdach S. Treatment of advanced Ewing tumors by combined radiochemotherapy and engineered cellular transplants. Pediatr Transplant. 2004 Jun;8 Suppl 5:67-82. doi: 10.1111/j.1398-2265.2004.00186.x.

Reference Type: BACKGROUND

PMID: 15125708 (View on PubMed)

Lucas KG, Schwartz C, Kaplan J. Allogeneic stem cell transplantation in a patient with relapsed Ewing sarcoma. Pediatr Blood Cancer. 2008 Jul;51(1):142-4. doi: 10.1002/pbc.21503.

Reference Type: BACKGROUND

PMID: 18266223 (View on PubMed)

Capitini CM, Derdak J, Hughes MS, Love CP, Baird K, Mackall CL, Fry TJ. Unusual sites of extraskeletal metastases of Ewing sarcoma after allogeneic hematopoietic stem cell transplantation. J Pediatr Hematol Oncol. 2009 Feb;31(2):142-4. doi: 10.1097/MPH.0b013e31819146e5.

Reference Type: BACKGROUND

PMID: 19194203 (View on PubMed)

Hosono A, Makimoto A, Kawai A, Takaue Y. Segregated graft-versus-tumor effect between CNS and non-CNS lesions of Ewing's sarcoma family of tumors. Bone Marrow Transplant. 2008 Jun;41(12):1067-8. doi: 10.1038/bmt.2008.26. Epub 2008 Mar 10. No abstract available.

Reference Type: BACKGROUND

PMID: 18332914 (View on PubMed)

Kido A, Amano I, Honoki K, Tanaka H, Morii T, Fujii H, Yoshitani K, Tanaka Y. Allogeneic and autologous stem cell transplantation in advanced small round cell sarcomas. J Orthop Sci. 2010 Sep;15(5):690-5. doi: 10.1007/s00776-010-1504-y. Epub 2010 Oct 16. No abstract available.

Reference Type: BACKGROUND

PMID: 20953934 (View on PubMed)

Fagioli F, Berger M, Brach del Prever A, Lioji S, Aglietta M, Ferrari S, Picci P, Madon E. Regression of metastatic osteosarcoma following non-myeloablative stem cell transplantation. A case report. Haematologica. 2003 May;88(5):ECR16.

Reference Type: BACKGROUND

PMID: 12745285 (View on PubMed)

Goi K, Sugita K, Tezuka T, Sato H, Uno K, Inukai T, Hamada Y, Nakazawa S. A successful case of allogeneic bone marrow transplantation for osteosarcoma with multiple metastases of lung and bone. Bone Marrow Transplant. 2006 Jan;37(1):115-6. doi: 10.1038/sj.bmt.1705209. No abstract available.

Reference Type: BACKGROUND

PMID: 16258530 (View on PubMed)

Ohta H, Hashii Y, Yoshida H, Kusuki S, Tokimasa S, Yoneda A, Fukuzawa M, Inoue N, Hara J, Kusafuka T, Ozono K. Allogeneic hematopoietic stem cell transplantation against recurrent rhabdomyosarcoma. J Pediatr Hematol Oncol. 2011 Jan;33(1):e35-8. doi: 10.1097/MPH.0b013e3181e7ddc5.

Reference Type: BACKGROUND

PMID: 20975586 (View on PubMed)

Donker AE, Hoogerbrugge PM, Mavinkurve-Groothuis AM, van de Kar NC, Boetes C, Hulsbergen-van de Kaa CA, Groot-Loonen JJ. Metastatic rhabdomyosarcoma cured after chemotherapy and allogeneic SCT. Bone Marrow Transplant. 2009 Jan;43(2):179-80. doi: 10.1038/bmt.2008.301. Epub 2008 Sep 1. No abstract available.

Reference Type: BACKGROUND

PMID: 18762761 (View on PubMed)

Baird K, Fry TJ, Steinberg SM, Bishop MR, Fowler DH, Delbrook CP, Humphrey JL, Rager A, Richards K, Wayne AS, Mackall CL. Reduced-intensity allogeneic stem cell transplantation in children and young adults with ultrahigh-risk pediatric sarcomas. Biol Blood Marrow Transplant. 2012 May;18(5):698-707. doi: 10.1016/j.bbmt.2011.08.020. Epub 2011 Sep 5.

Reference Type: BACKGROUND

PMID: 21896345 (View on PubMed)

Childs R, Chernoff A, Contentin N, Bahceci E, Schrump D, Leitman S, Read EJ, Tisdale J, Dunbar C, Linehan WM, Young NS, Barrett AJ. Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. N Engl J Med. 2000 Sep 14;343(11):750-8. doi: 10.1056/NEJM200009143431101.

Reference Type: BACKGROUND

PMID: 10984562 (View on PubMed)

Scott M, Lawrance J, Dennis M. Regression of a renal cell carcinoma following allogeneic peripheral blood stem cell transplant for acute myeloid leukaemia: evidence of a graft-versus-tumour effect without significant graft-versus-host disease. Br J Haematol. 2012 Oct;159(1):1. doi: 10.1111/j.1365-2141.2012.09238.x. Epub 2012 Jul 27. No abstract available.

Reference Type: BACKGROUND

PMID: 22845006 (View on PubMed)

Baek HJ, Han DK, Hwang TJ, Bae SH, Choi YD, Kook H. Long-term graft-versus-tumor effect following reduced intensity hematopoietic stem cell transplantation in a child with metastatic renal cell carcinoma. Pediatr Blood Cancer. 2012 Sep;59(3):583-5. doi: 10.1002/pbc.24074. Epub 2012 Jan 9.

Reference Type: BACKGROUND

PMID: 22231905 (View on PubMed)

Inaba H, Handgretinger R, Furman W, Hale G, Leung W. Allogeneic graft-versus-hepatoblastoma effect. Pediatr Blood Cancer. 2006 Apr;46(4):501-5. doi: 10.1002/pbc.20404.

Reference Type: BACKGROUND

PMID: 15806543 (View on PubMed)

Pappo AS, Anderson JR, Crist WM, Wharam MD, Breitfeld PP, Hawkins D, Raney RB, Womer RB, Parham DM, Qualman SJ, Grier HE. Survival after relapse in children and adolescents with rhabdomyosarcoma: A report from the Intergroup Rhabdomyosarcoma Study Group. J Clin Oncol. 1999 Nov;17(11):3487-93. doi: 10.1200/JCO.1999.17.11.3487.

Reference Type: BACKGROUND

PMID: 10550146 (View on PubMed)

Bowers DC, Gargan L, Weprin BE, Mulne AF, Elterman RD, Munoz L, Giller CA, Winick NJ. Impact of site of tumor recurrence upon survival for children with recurrent or progressive medulloblastoma. J Neurosurg. 2007 Jul;107(1 Suppl):5-10. doi: 10.3171/PED-07/07/005.

Reference Type: BACKGROUND

PMID: 17644914 (View on PubMed)

Other Identifiers

2014-3856

Identifier Type: -

Identifier Source: org_study_id