Comparison of Brain Perfusion in Rhythm Control and Rate Control of Persistent Atrial Fibrillation
NCT ID: NCT02633774
Last Updated: 2019-01-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
200 participants
INTERVENTIONAL
2015-11-30
2020-11-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Rhythm control group
1\. Start AAD right after evaluating for LA size, EF, LA thrombus, and presence of CAD during anticoagulation 2. check the echo, brain perfusion CT and K-MOCA on baseline 3. confirm a thrombus through the TEE 4. Cardioversion after 1 month 5. Rhythm FU schedule (2012 ACC/AHA/ESC guidelines) 6. If AF recur, RFCA 7. check the brain perfusion CT, K-MOCA after 3M and 12M
Propafenone
AAD(antiarrhythmic drug)
Rate control group
1\. No AAD, just anticoagulation 2. HR control between 60\~110bpm (with beta blocker, calcium channel blocker, digoxin) 3. check the echo, brain perfusion CT and K-MOCA on baseline 4. check the brain perfusion CT and K-MOCA after 3M and 12M 5. Without the treatment about antiarrythmia and rhythm control, diffication of rate control, the subject will be drop out for study.
Apixaban
anti-coagulation
Interventions
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Propafenone
AAD(antiarrhythmic drug)
Apixaban
anti-coagulation
Eligibility Criteria
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Inclusion Criteria
* LA diameter \< 55mm
* patients possible to anticoagulation and anti arrhythmic drug
Exclusion Criteria
* Contraindication to brain perfusion CT
* Catheter ablation history for AF, Cardiac surgery
* active internal bleeding
* Impossible to anticoagulation or antiarrhythmic drug
* valvular AF ((MA\> GII, Mechanical valve, Mitral valve replacement)
* LVEF \< 30%
* With severe medical disease
* Expected survival \< 1 year
* Severe alcoholics, drug addiction
20 Years
80 Years
ALL
No
Sponsors
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Yonsei University
OTHER
Responsible Party
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Locations
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Severance Cardiovascular Hospital, Yonsei University Health System
Seoul, , South Korea
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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4-2015-0914
Identifier Type: -
Identifier Source: org_study_id
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