Proton Pump Inhibitors Use in Patients With Psoriasis

NCT ID: NCT02624544

Last Updated: 2022-08-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

PHASE4

Study Classification

INTERVENTIONAL

Study Start Date

2016-01-31

Study Completion Date

2016-12-31

Brief Summary

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Proton pump inhibitors act in blocking acid secretion and also have antioxidant and anti-inflammatory properties. For that mechanisms possibly PPIs may have an anti-inflammatory action with improvement in skin lesions in patients with psoriasis.

Detailed Description

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Proton pump inhibitors act in blocking acid secretion and also have antioxidant and anti-inflammatory properties. For that mechanisms possibly PPIs may have an anti-inflammatory action with improvement in skin lesions in patients with psoriasis.

The study will assess the evolution of skin lesions in psoriasis patients using PPIs

Conditions

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Psoriasis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group A

Proton Pump Inhibitor esomeprazole 40 mg twice a day

Group Type EXPERIMENTAL

esomeprazole

Intervention Type DRUG

esomex 40 mg twice daily

Group B

desonide

Group Type ACTIVE_COMPARATOR

desonide

Intervention Type DRUG

topical corticosteroid desonid 0,1% b.i.d

Interventions

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esomeprazole

esomex 40 mg twice daily

Intervention Type DRUG

desonide

topical corticosteroid desonid 0,1% b.i.d

Intervention Type DRUG

Other Intervention Names

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esomex corticosteroid

Eligibility Criteria

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Inclusion Criteria

* Diagnostic of Psoriasis

Exclusion Criteria

* Pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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EMS

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

References

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Rahman M, Alam K, Ahmad MZ, Gupta G, Afzal M, Akhter S, Kazmi I, Jyoti, Ahmad FJ, Anwar F. Classical to current approach for treatment of psoriasis: a review. Endocr Metab Immune Disord Drug Targets. 2012 Sep;12(3):287-302. doi: 10.2174/187153012802002901.

Reference Type RESULT
PMID: 22463723 (View on PubMed)

Other Identifiers

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EMS

Identifier Type: -

Identifier Source: org_study_id

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