Deconditioning in Transplant

NCT ID: NCT02611219

Last Updated: 2016-05-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-03-31

Study Completion Date

2016-04-30

Brief Summary

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The purpose of this feasibility study is to test the potential for successful implementation of an intervention designed to study the effect of six hours out of bed time on the overall level of deconditioning in pediatric stem cell transplant (SCT) patients. Previous research has demonstrated that deconditioning occurs rapidly over the course of the hospitalization post-transplant and can negatively impact quality of life. By encouraging patients to be out of bed for six hours each day, it is anticipated that patients will experience less deconditioning than those patients who previously had no established minimum time out of the bed.

Detailed Description

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Conditions

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Hematopoietic and Stem Cell Transplant

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Arm 1: Pediatric patients

* Patients will wear a Fitbit Flex during hospitalization
* Completion of Demographic Data Form at baseline, discharge from hospital, and at the six week clinic visit
* Assist in recording time out of bed using the SCT Daily Activity Log
* Fill out (some with help of parents) applicable questionnaires: Child Health Ratings Inventories-General Health Module (5-12 years), General Health Module-Baseline Adolescent-Self Report (13-18 years), General Health Module-Follow Up Adolescent-Self Report (13-18 years) at baseline, discharge from hospital, and at six week clinic visit
* Patients will be assessed using standard physical therapy assessment tools to determine functioning, muscle strength, endurance, and mobility: The Functional Independence Measure for Children and Manual Muscle Testing is done weekly, discharge from hospital, and at six week clinic visit. The 3-Minute Step Test is done at admission, discharge from hospital, and at six week clinic visit.

Group Type EXPERIMENTAL

3-Minute Step Test

Intervention Type OTHER

* Using an aerobic step, the participant walks up and down for a given amount of time with the heart rate being checked before and after
* Using the difference in heart rate and a shortness of breath scale, this test is able to give an estimate of aerobic tolerance

HSCT Module-Follow Up Adolescent-Self Report (13-18 years)

Intervention Type OTHER

* 7 question questionnaire about child
* Answers range from 1=all of the time to 5=none of the time

HSCT Module-Follow Child-Self Report (5-12 years)

Intervention Type OTHER

* 10 question questionnaire about child
* Answers range from 1=all of the time to 5=none of the time

General Health Module-Baseline Adolescent-Self Report (13-18 years)

Intervention Type OTHER

* 38 question questionnaire
* Answers range from 1=all of the time to 5=none of the time

General Health Module-Follow Up Adolescent-Self Report (13-18 years)

Intervention Type OTHER

* 38 question questionnaire about child
* Answers range from 1=all of the time to 5=none of the time

Demographic Data Form

Intervention Type OTHER

-16 questions about demographics such as household income, race, and gender

SCT Daily Activity Log

Intervention Type OTHER

* Uses Fitbit Flex
* Log that lists time in 15 minute increments and allows for checking when out of bed and describing the activity that occurred while out of bed

The Functional Independence Measure for Children

Intervention Type OTHER

* 18-item, 7-level ordinal scale instrument that measures a child's consistent performance in essential daily functional skills. Three main domains (selfcare, mobility, and cognition) are assessed by interviewing or by observing a child's performance of a task to criterion standards
* Categorized into 2 main functional streams: "Dependent" (ie, requires helper: scores 1-5) and "Independent" (ie, requires no helper: scores 6-7). Scores 1 (total assistance) and 2 (maximal assistance) belongs to the "Complete Dependence" category. Scores 3 (moderate assistance), 4 (minimal contact assistance), and 5 (supervision or set-up) belongs to the "Modified Dependence" category. Scores 6 (modified independence) and 7 (complete independence) belongs to the "Independent" category.

Manual Muscle Testing

Intervention Type OTHER

-Isometric muscle strength is tested in specific positions, usually with the muscle at an optimal working length. Using a "break" test, the test giver overpowers the muscle being tested to determine the muscle grade.

Arm 2: Parents of pediatric patients

* Parents will be considered participants as they will be completing study questionnaires.
* Completion of Demographic Data Form at baseline
* Assist in recording time out of bed using the SCT Daily Activity Log
* Fill out applicable questionnaires: General Health Module-Baseline Parent Report -Adolescent (13-18 Years), General Health Module-Follow Up Parent Report-Adolescent (13-18 years), General Health Module-Baseline Parent Report-School Age (5-12 years), and General Health Module Follow Up Parent Report-School Age (5-12 years), HSCT Module-Follow UP Parent Report School Age (5-12 years), HSCT Module-Follow Up Parent Report Adolescent (13-18 years), HSCT Module-Follow Up Adolescent-Self Report (13-18 years), HSCT Module-Follow Child-Self Report (5-12 years) at baseline, discharge from hospital, and at six week clinic visit.
* Assist child with Child Health Ratings Inventories-General Health Module (5-12 years) at baseline, discharge at hospital, and at six week clinic visit

Group Type EXPERIMENTAL

General Health Module-Baseline Parent Report-Adolescent (13-18 years)

Intervention Type OTHER

* 38 question questionnaire about child
* 49 question questionnaire about parent
* Answers range from 1-all of the time to 5=none of the time

General Health Module-Follow Up Parent Report-Adolescent (13-18 years)

Intervention Type OTHER

* 38 question questionnaire about child
* 49 question questionnaire about parent
* Answers range from 1-all of the time to 5=none of the time

General Health Module-Baseline Parent Report-School Age (5-12 years)

Intervention Type OTHER

* 34 question questionnaire about child
* 49 question questionnaire about parent
* Answers range from 1-all of the time to 5=none of the time

General Health Module-Follow Up Parent Report-School Age (5-12 years)

Intervention Type OTHER

* 34 question questionnaire about child
* 49 question questionnaire about parent
* Answers range from 1-all of the time to 5=none of the time

Demographic Data Form

Intervention Type OTHER

-16 questions about demographics such as household income, race, and gender

SCT Daily Activity Log

Intervention Type OTHER

* Uses Fitbit Flex
* Log that lists time in 15 minute increments and allows for checking when out of bed and describing the activity that occurred while out of bed

HSCT Module-Follow Up Parent Report-adolescent (13-18 years)

Intervention Type OTHER

* 7 question questionnaire about child
* 49 question questionnaire about parent
* Answers range from 1=all of the time to 5=none of the time

HSCT Module-Follow Up Parent Report-School Age (5-12 years)

Intervention Type OTHER

* 7 question questionnaire about child
* 49 question questionnaire about parent
* Answers range from 1=all of the time to 5=none of the time

Interventions

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3-Minute Step Test

* Using an aerobic step, the participant walks up and down for a given amount of time with the heart rate being checked before and after
* Using the difference in heart rate and a shortness of breath scale, this test is able to give an estimate of aerobic tolerance

Intervention Type OTHER

HSCT Module-Follow Up Adolescent-Self Report (13-18 years)

* 7 question questionnaire about child
* Answers range from 1=all of the time to 5=none of the time

Intervention Type OTHER

HSCT Module-Follow Child-Self Report (5-12 years)

* 10 question questionnaire about child
* Answers range from 1=all of the time to 5=none of the time

Intervention Type OTHER

General Health Module-Baseline Adolescent-Self Report (13-18 years)

* 38 question questionnaire
* Answers range from 1=all of the time to 5=none of the time

Intervention Type OTHER

General Health Module-Follow Up Adolescent-Self Report (13-18 years)

* 38 question questionnaire about child
* Answers range from 1=all of the time to 5=none of the time

Intervention Type OTHER

General Health Module-Baseline Parent Report-Adolescent (13-18 years)

* 38 question questionnaire about child
* 49 question questionnaire about parent
* Answers range from 1-all of the time to 5=none of the time

Intervention Type OTHER

General Health Module-Follow Up Parent Report-Adolescent (13-18 years)

* 38 question questionnaire about child
* 49 question questionnaire about parent
* Answers range from 1-all of the time to 5=none of the time

Intervention Type OTHER

General Health Module-Baseline Parent Report-School Age (5-12 years)

* 34 question questionnaire about child
* 49 question questionnaire about parent
* Answers range from 1-all of the time to 5=none of the time

Intervention Type OTHER

General Health Module-Follow Up Parent Report-School Age (5-12 years)

* 34 question questionnaire about child
* 49 question questionnaire about parent
* Answers range from 1-all of the time to 5=none of the time

Intervention Type OTHER

Demographic Data Form

-16 questions about demographics such as household income, race, and gender

Intervention Type OTHER

SCT Daily Activity Log

* Uses Fitbit Flex
* Log that lists time in 15 minute increments and allows for checking when out of bed and describing the activity that occurred while out of bed

Intervention Type OTHER

The Functional Independence Measure for Children

* 18-item, 7-level ordinal scale instrument that measures a child's consistent performance in essential daily functional skills. Three main domains (selfcare, mobility, and cognition) are assessed by interviewing or by observing a child's performance of a task to criterion standards
* Categorized into 2 main functional streams: "Dependent" (ie, requires helper: scores 1-5) and "Independent" (ie, requires no helper: scores 6-7). Scores 1 (total assistance) and 2 (maximal assistance) belongs to the "Complete Dependence" category. Scores 3 (moderate assistance), 4 (minimal contact assistance), and 5 (supervision or set-up) belongs to the "Modified Dependence" category. Scores 6 (modified independence) and 7 (complete independence) belongs to the "Independent" category.

Intervention Type OTHER

Manual Muscle Testing

-Isometric muscle strength is tested in specific positions, usually with the muscle at an optimal working length. Using a "break" test, the test giver overpowers the muscle being tested to determine the muscle grade.

Intervention Type OTHER

HSCT Module-Follow Up Parent Report-adolescent (13-18 years)

* 7 question questionnaire about child
* 49 question questionnaire about parent
* Answers range from 1=all of the time to 5=none of the time

Intervention Type OTHER

HSCT Module-Follow Up Parent Report-School Age (5-12 years)

* 7 question questionnaire about child
* 49 question questionnaire about parent
* Answers range from 1=all of the time to 5=none of the time

Intervention Type OTHER

Other Intervention Names

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WeeFIM MMT

Eligibility Criteria

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Inclusion Criteria

* Ages 7-17 years
* Admitted to hospital for stem cell transplant
* Speaks English


* Parents of children ages 7-17 years
* Parents of children admitted to hospital for stem cell transplant
* Speaks English

Exclusion Criteria

-Parents of children admitted to transplant unit for autologous stem cell transplant, donor lymphocyte infusions, mesenchymal cell infusions, a second stem cell transplant, graft versus host disease or other complications post stem cell transplant will not be included
Minimum Eligible Age

7 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Washington University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Heather Taylor, RN, BSN, CPHON

Role: PRINCIPAL_INVESTIGATOR

Washington University School of Medicine

Locations

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Washington University School of Medicine

St Louis, Missouri, United States

Site Status

Countries

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United States

Related Links

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http://www.siteman.wustl.edu

Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine

Other Identifiers

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201406031

Identifier Type: -

Identifier Source: org_study_id

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