Comparative Bioavailability of Dronabinol Oral Solution in Healthy Volunteers

NCT ID: NCT02604992

Last Updated: 2016-01-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

54 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-11-30

Study Completion Date

2015-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The primary objective of this study is to evaluate the comparative bioavailability of a test product of dronabinol oral solution administered under fed conditions to the reference listed drug (RLD) administered to participants under fed and fasted conditions.

The secondary objective is to compare the onset of detectable dronabinol concentrations between dronabinol oral solution and the RLD.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Healthy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Group 1 (A,B,C)

With a 7-day washout between periods, participants are randomized to receive Treatment A, Treatment B, and then Treatment C.

Group Type EXPERIMENTAL

Treatment A

Intervention Type DRUG

Dronabinol oral solution, under fed conditions

Treatment B

Intervention Type DRUG

Dronabinol oral capsule, under fed conditions

Treatment C

Intervention Type DRUG

Dronabinol oral capsule, under fasted conditions

Group 2 (B,C,A)

With a 7-day washout between periods, participants are randomized to receive Treatment B, Treatment C, and then Treatment A.

Group Type EXPERIMENTAL

Treatment A

Intervention Type DRUG

Dronabinol oral solution, under fed conditions

Treatment B

Intervention Type DRUG

Dronabinol oral capsule, under fed conditions

Treatment C

Intervention Type DRUG

Dronabinol oral capsule, under fasted conditions

Group 3 (C,A,B)

With a 7-day washout between periods, participants are randomized to receive Treatment C, Treatment A, and then Treatment B.

Group Type EXPERIMENTAL

Treatment A

Intervention Type DRUG

Dronabinol oral solution, under fed conditions

Treatment B

Intervention Type DRUG

Dronabinol oral capsule, under fed conditions

Treatment C

Intervention Type DRUG

Dronabinol oral capsule, under fasted conditions

Group 4 (C,B,A)

With a 7-day washout between periods, participants are randomized to receive Treatment C, Treatment B, and then Treatment A.

Group Type EXPERIMENTAL

Treatment A

Intervention Type DRUG

Dronabinol oral solution, under fed conditions

Treatment B

Intervention Type DRUG

Dronabinol oral capsule, under fed conditions

Treatment C

Intervention Type DRUG

Dronabinol oral capsule, under fasted conditions

Group 5 (A,C,B)

With a 7-day washout between periods, participants are randomized to receive Treatment A, Treatment C, and then Treatment B.

Group Type EXPERIMENTAL

Treatment A

Intervention Type DRUG

Dronabinol oral solution, under fed conditions

Treatment B

Intervention Type DRUG

Dronabinol oral capsule, under fed conditions

Treatment C

Intervention Type DRUG

Dronabinol oral capsule, under fasted conditions

Group 6 (B,A,C)

With a 7-day washout between periods, participants are randomized to receive Treatment B, Treatment A, and then Treatment C.

Group Type EXPERIMENTAL

Treatment A

Intervention Type DRUG

Dronabinol oral solution, under fed conditions

Treatment B

Intervention Type DRUG

Dronabinol oral capsule, under fed conditions

Treatment C

Intervention Type DRUG

Dronabinol oral capsule, under fasted conditions

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Treatment A

Dronabinol oral solution, under fed conditions

Intervention Type DRUG

Treatment B

Dronabinol oral capsule, under fed conditions

Intervention Type DRUG

Treatment C

Dronabinol oral capsule, under fasted conditions

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Marinol Marinol

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Meets protocol-specified criteria for qualification
* Fully comprehends and signs the informed consent form, understands all study procedures, and can communicate satisfactorily with the Investigator and study coordinator

Exclusion Criteria

* History or current use of over-the-counter medications, dietary supplements, or drugs outside protocol-specified parameters
* Signs, symptoms or history of any condition that, per protocol or in the opinion of the investigator, might compromise:

1. the safety or well-being of the participant or study staff
2. the safety or well-being of the participant's offspring (such as through pregnancy or breast-feeding)
3. the analysis of results
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

INSYS Therapeutics Inc

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Neha Parikh

Role: STUDY_DIRECTOR

INSYS Therapeutics Inc

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Worldwide Clinical Trials Early Phase Services, LLC

San Antonio, Texas, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

INS004-15-059

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

The Effects of ∆-9-THC and Naloxone in Humans
NCT01591629 COMPLETED EARLY_PHASE1
Age-Related Effects of THC
NCT04294966 COMPLETED EARLY_PHASE1
Drug-Drug Interaction Between THC and AEF0117
NCT06395688 NOT_YET_RECRUITING PHASE1