Tools for Therapeutic Evaluation in Charcot-Marie-Tooth Disease Type 1A: Outcome Measures and Biomarkers
NCT ID: NCT02596191
Last Updated: 2025-06-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
80 participants
INTERVENTIONAL
2016-06-06
2027-12-05
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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patients with mild CMT 1A disease
Charcot-Marie-Tooth Neuropathy Score between 1 and 10
Clinical evaluation
electrophysiological record
Muscle MRI
blood samples analysis
patients with moderate CMT 1A disease
Charcot-Marie-Tooth Neuropathy Score between 11 and 20
Clinical evaluation
electrophysiological record
Muscle MRI
blood samples analysis
patients with severe CMT 1A disease
Charcot-Marie-Tooth Neuropathy Score ≥21
Clinical evaluation
electrophysiological record
Muscle MRI
blood samples analysis
control group
Healthy volunteers
Muscle MRI
blood samples analysis
Interventions
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Clinical evaluation
electrophysiological record
Muscle MRI
blood samples analysis
Eligibility Criteria
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Inclusion Criteria
* Diagnosis of CMT 1A confirmed by genotyping (duplication of the 17p11.2 region)
Exclusion Criteria
* With HIV or cancer
* With a significant progressive disease in the previous month
* With a contra-indication for MRI
* With a dislocation, fracture, or recent surgery (less than 6 months before inclusion)
* with alcohol or psychoactive substances abuse
* Treated by an anti-inflammatory drug over the past four weeks
* Pregnant or breastfeeding women
* Homeless patients
18 Years
70 Years
ALL
Yes
Sponsors
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Assistance Publique Hopitaux De Marseille
OTHER
Responsible Party
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Principal Investigators
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Urielle Desalbres
Role: STUDY_DIRECTOR
Assistance Publique Hôpitaux de Marseille
Locations
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Assistance Publique Hôpitaux de Marseille
Marseille, , France
CHU Gui de Chauliac, CHU MONTPELLIER
Montpellier, , France
Countries
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Other Identifiers
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2014-10
Identifier Type: -
Identifier Source: org_study_id
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