Clinical Trial of YH14755 in Subjects With Dyslipidemia and Type II Diabetes

NCT ID: NCT02586129

Last Updated: 2018-10-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

249 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-11-04

Study Completion Date

2017-07-07

Brief Summary

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Randomized, double-blind, active-controlled, multicenter phase 3 trial to evaluate the safety and efficacy of YH14755 in subjects with dyslipidemia and Type II Diabetes.

Detailed Description

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This is a phase 3 trial to evaluate the safety and efficacy of YH14755 in subjects with dyslipidemia and Type II Diabetes.

In YH14755 treatment group, 88 subjects will be assigned and the subjects administer YH14755 for 16 weeks.

In Metformin treatment group, 88 subjects will be assigned and the subjects administer Metformin for 16 weeks.

In Rosuvastatin treatment group, 88 subjects will be assigned and the subjects administer Rosuvastatin for 16 weeks.

Conditions

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Dyslipidemia Type II Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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YH14755

PO, Once Daily, 16 weeks

Group Type EXPERIMENTAL

YH14755

Intervention Type DRUG

20/1500mg, QD

Metformin

PO, Once Daily, 16 weeks

Group Type ACTIVE_COMPARATOR

Metformin

Intervention Type DRUG

1500mg, QD

Rosuvastatin

PO, Once Daily, 16 weeks

Group Type ACTIVE_COMPARATOR

Rosuvastatin

Intervention Type DRUG

20mg, QD

Interventions

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YH14755

20/1500mg, QD

Intervention Type DRUG

Metformin

1500mg, QD

Intervention Type DRUG

Rosuvastatin

20mg, QD

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Signed Informed Consent
* Subjects with Dyslipidemia and Type II Diabetes
* 6.5% ≤ HbA1c level ≤ 9.0% and LDL-C level ≤ 250mg/dL(6.5 nmal/L) at screening
* BMI ≤ 45kg/m2
* Subjects who dose not administered diabetes treatment at least 4 weeks prior to screening visit.
* 19 years later, men and women under the age of 75

Exclusion Criteria

* Pregnant women, nursing mothers or subject who does not agree to assigned contraception in the study
* Subject with type I Diabetes
* Subject with hypertension which does not controlled by treatment(have blood pressure \> 160/110mmHg)
* Have a known allergy to drugs
* Have administered Cyclosporine
* Have administered Obesity treatment within 12 weeks prior to screening visit
* Participated in any other clinical trials within 30 days prior to the first administration
* Subject who is judged to be ineligible by investigator
Minimum Eligible Age

19 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Yuhan Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hakcheol Jang, M.D., Ph.D.

Role: STUDY_CHAIR

Department of Internal Medicine, SNU Bundang Hospital

Locations

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Seoul National Universitiy Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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YH14755-301

Identifier Type: -

Identifier Source: org_study_id

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