Prevena Vascular Groin Wound Study

NCT ID: NCT02581904

Last Updated: 2015-10-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-31

Study Completion Date

2018-02-28

Brief Summary

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The purpose of this study is to determine if the application of a negative pressure dressing intraoperatively (Prevena; KCI, Inc) to vascular groin incisions decreases the wound complication rate in high risk patients.

Detailed Description

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The study randomizes patients (1:1) considered high risk, according to a specific set of risk factors, for wound complications into standard post-op dressings vs. Prevena vacuum dressing. The wounds will then be assessed for wound complications in the 30 days postoperatively. Wound complications include breakdown, infection and lymph leak. Patients not considered high risk will have standard post-op dressings and followed similarly to controls. The investigators will also assess economic impact of negative pressure dressing on length of stay and overall inpatient costs.

Conditions

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Wound Infection Peripheral Arterial Disease Aneurysm Surgical Wound Dehiscence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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High Risk - Prevena Care

The Prevena device is a product from KCI and is a sterile sponge that covers the closed incision. The device is placed sterile in the operating room and suction is then applied to the sponge for 5-7 days.

Group Type EXPERIMENTAL

Prevena Care

Intervention Type DEVICE

The Prevena device is a product from KCI and is a sterile sponge that covers the closed incision. The device is placed sterile in the operating room and suction is then applied to the sponge for 5-7 days.

High Risk - Dry Gauze Dressing Care

Initial dry gauze dressing will be placed sterile in the operating room and will be changed daily

Group Type ACTIVE_COMPARATOR

Dry gauze dressing care

Intervention Type DEVICE

Initial dry gauze dressing will be placed sterile in the operating room and will be changed daily

Low Risk - Dry Gauze Dressing Care

Initial dry gauze dressing will be placed sterile in the operating room and will be changed daily

Group Type ACTIVE_COMPARATOR

Dry gauze dressing care

Intervention Type DEVICE

Initial dry gauze dressing will be placed sterile in the operating room and will be changed daily

Interventions

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Prevena Care

The Prevena device is a product from KCI and is a sterile sponge that covers the closed incision. The device is placed sterile in the operating room and suction is then applied to the sponge for 5-7 days.

Intervention Type DEVICE

Dry gauze dressing care

Initial dry gauze dressing will be placed sterile in the operating room and will be changed daily

Intervention Type DEVICE

Other Intervention Names

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Closed Incision Negative Pressure Device

Eligibility Criteria

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Inclusion Criteria

* All patients undergoing a femoral incision during vascular reconstruction or repair will be considered for study

Exclusion Criteria

* Emergency procedure
* Unable to give informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Thomas Jefferson University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Paul DiMuzio, MD

Role: PRINCIPAL_INVESTIGATOR

Thomas Jefferson University

Locations

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Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, United States

Site Status

Countries

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United States

References

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Correia RM, Nakano LC, Vasconcelos V, Cristino MA, Flumignan RL. Prevention of infection in peripheral arterial reconstruction of the lower limb. Cochrane Database Syst Rev. 2025 Oct 29;10:CD015022. doi: 10.1002/14651858.CD015022.pub2.

Reference Type DERIVED
PMID: 41159585 (View on PubMed)

Cristino MA, Nakano LC, Vasconcelos V, Correia RM, Flumignan RL. Prevention of infection in aortic or aortoiliac peripheral arterial reconstruction. Cochrane Database Syst Rev. 2025 Apr 22;4(4):CD015192. doi: 10.1002/14651858.CD015192.pub2.

Reference Type DERIVED
PMID: 40260835 (View on PubMed)

Kwon J, Staley C, McCullough M, Goss S, Arosemena M, Abai B, Salvatore D, Reiter D, DiMuzio P. A randomized clinical trial evaluating negative pressure therapy to decrease vascular groin incision complications. J Vasc Surg. 2018 Dec;68(6):1744-1752. doi: 10.1016/j.jvs.2018.05.224. Epub 2018 Aug 17.

Reference Type DERIVED
PMID: 30126781 (View on PubMed)

Other Identifiers

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7179

Identifier Type: -

Identifier Source: org_study_id

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