Negative Pressure Dressing After Saphenous Vein Harvest

NCT ID: NCT01698372

Last Updated: 2015-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

64 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-09-30

Study Completion Date

2015-03-31

Brief Summary

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This study will test the effectiveness of negative pressure wound therapy (using the VAC Prevena device, KCI Canada Inc.) applied to the saphenous vein harvest site after Coronary Artery Bypass Grafting (CABG). When initiated immediately after surgery, this intervention may decrease the incidence of wound infection and non-infectious wound complications. It may decrease wound discomfort and improve mobility and functional recovery of the leg.

Detailed Description

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Conditions

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Coronary Artery Disease Complication of Coronary Artery Bypass Graft Wound Complication

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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Prevena device (Group A)

Group A will have the VAC Prevena portable device applied to the saphenous vein harvest site after standard wound closure following coronary artery bypass surgery.

Group Type EXPERIMENTAL

Prevena device (Group A)

Intervention Type DEVICE

This portable device is applied to initiate negative pressure therapy to a wound site.

Conventional dressing (Group B)

Group B will have conventional dry dressing applied to the saphenous vein harvest site after standard wound closure following coronary artery bypass surgery.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Prevena device (Group A)

This portable device is applied to initiate negative pressure therapy to a wound site.

Intervention Type DEVICE

Other Intervention Names

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Prevena Incision Management System Prevena 125 PRE1001.S Prevena Incision Kit

Eligibility Criteria

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Inclusion Criteria

* Patients presenting for elective or semi-elective isolated first-time CABG surgery with harvesting of the greater saphenous vein.
* Must be 18 years or older.
* Must live with one hour driving distance from Calgary.
* Must provide written consent.

Exclusion Criteria

* Previous CABG surgery or previous lower leg surgical intervention.
* In emergent need for surgery.
* Have severe peripheral vascular disease.
* Do not speak and read the English language.
* Have dialysis-dependent renal failure.
* Require chronic steroids.
* Unable to return to clinic for follow-up due to functional or cognitive impairment.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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KCI USA, Inc

INDUSTRY

Sponsor Role collaborator

University of Calgary

OTHER

Sponsor Role lead

Responsible Party

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Dr. Paul Fedak

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Paul Fedak, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Calgary

Locations

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Libin Cardiovascular Institute, Foothills Medical Centre

Calgary, Alberta, Canada

Site Status

Countries

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Canada

References

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Lee AJ, Sheppard CE, Kent WD, Mewhort H, Sikdar KC, Fedak PW. Safety and efficacy of prophylactic negative pressure wound therapy following open saphenous vein harvest in cardiac surgery: a feasibility study. Interact Cardiovasc Thorac Surg. 2017 Mar 1;24(3):324-328. doi: 10.1093/icvts/ivw400.

Reference Type DERIVED
PMID: 28025309 (View on PubMed)

Other Identifiers

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KCI VAC Study

Identifier Type: -

Identifier Source: org_study_id