A Thorough ECG Study in Subjects With Acne Vulgaris Treated With SB204

NCT ID: NCT02581072

Last Updated: 2018-11-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

56 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-31

Study Completion Date

2016-04-30

Brief Summary

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A Double-Blind, Double-Dummy, Randomized, 4-Period Crossover Study to Define the ECG Effects of SB204 Using a Clinical and Supratherapeutic Dose Compared with Placebo and Moxifloxacin (a Positive Control) in Subjects with Acne Vulgaris: A Thorough ECG Study

Detailed Description

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A Double-Blind, Double-Dummy, Randomized, 4-Period, Crossover Study to Define the ECG Effects of SB204 Using a Clinical and a Supratherapeutic Dose Compared with Placebo and Moxifloxacin (a Positive Control) in Subjects with Acne Vulgaris: A Thorough ECG Study

Conditions

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Acne Vulgaris

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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SB204 4%

SB204 4% once

Group Type EXPERIMENTAL

SB204 4%

Intervention Type DRUG

Applied topically once

SB204 8% or 12 %

SB204 8 or 12 % (supratherapeutic) once

Group Type EXPERIMENTAL

SB204 8% or 12%

Intervention Type DRUG

Applied once topically

Moxifloxacillin

Moxifloxacillin 400 mg orally

Group Type NO_INTERVENTION

No interventions assigned to this group

Vehicle Gel

Placebo

Group Type PLACEBO_COMPARATOR

Vehicle

Intervention Type DRUG

Applied topically once

Interventions

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SB204 4%

Applied topically once

Intervention Type DRUG

SB204 8% or 12%

Applied once topically

Intervention Type DRUG

Vehicle

Applied topically once

Intervention Type DRUG

Other Intervention Names

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NVN1000 NVN1000 Placebo

Eligibility Criteria

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Inclusion Criteria

* Moderate to severe acne
* 20 inflammatory and 25 non-inflammatory acne lesions

Exclusion Criteria

* Pregnant, trying to become pregnant, or nursing
* Known allergy to any component of the topical SB204 formulation
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Spaulding Clinical Research LLC

OTHER

Sponsor Role collaborator

Novan, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Joyce Rico, MD

Role: PRINCIPAL_INVESTIGATOR

Novan, Inc.

Locations

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Spaulding Clinical Research, LLC

West Bend, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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NI-AC104

Identifier Type: -

Identifier Source: org_study_id

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