PartoSure to Predict Spontaneous Preterm Delivery in Pregnancies After Assisted Reproductive Technology (ART)

NCT ID: NCT02576418

Last Updated: 2017-09-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-31

Study Completion Date

2017-12-31

Brief Summary

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To calculate sensitivity (SN), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV) of PartoSure TTD test in predicting delivery within 7 or 14 days from testing and to compare it with cervical length (CL) measurement by transvaginal ultrasound (15 mm cut-off)

Detailed Description

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* This trial is a prospective observational study.
* Pregnancies after ART between 20 0/7 and 36 6/7 weeks with symptoms of preterm labor, clinically intact membranes, cervical dilatation of ≤ 2 cm will be invited to participate to the study. Signed consent form is required to be able to participate to the study.
* PartoSure and CL will be performed on all patients and the test-to-spontaneous-delivery interval will be calculated.
* Trial Population:Pregnancies after ART between 20 0/7 and 36 6/7 weeks with symptoms of preterm labor are hospitalized at My Duc hospital from October 2015 to April 2016. The sample size for this trial of 100 subjects.

Conditions

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Infertility

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Partosure TTD Test

PartoSure TTD test will be performed on all patients and the test-to-spontaneous-delivery interval will be calculated.

Group Type EXPERIMENTAL

Partosure TTD test

Intervention Type OTHER

PartoSure TTD test and CL will be performed on all patients and the test-to-spontaneous-delivery interval will be calculated.

Interventions

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Partosure TTD test

PartoSure TTD test and CL will be performed on all patients and the test-to-spontaneous-delivery interval will be calculated.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

To be eligible for enrollment into this trial, each female subject must fulfill all of the following criteria at the start of enrollment:

* Pregnancies after assisted reproductive technology include singleton and twins
* Between 20 0/7 and 36 6/7 weeks with symptoms of preterm labor including uterine contractions, intermittent lower abdominal pain and pelvic pressure.
* Clinically intact membranes.
* Cervical dilatation of ≤ 2 cm
* Agree to participate in the study, and to disclose any medical events to the investigator
* Have given written informed consent

Exclusion Criteria

To be eligible for enrollment in this study each subject must not meet any of the following criteria:

* Vaginal bleeding
* Overt rupture of the fetal membranes as indicated by visualized leakage of fluid from the cervix
* Placenta previa
* Cervical cerclage in place
* Received tocolytic medications for treatment of threatened preterm delivery prior to collection of the cervicovaginal specimens or CL measurement.
* Digital exam prior to specimen collection.
* A symptom not associated with idiopathic threatened preterm delivery (e.g trauma)
* Enrollment in a tocolytic study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Vietnam National University

OTHER

Sponsor Role lead

Responsible Party

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Manh Tuong Ho

Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Tuong M Ho, Doctor

Role: STUDY_DIRECTOR

Research Center for Genetics and Reproductive Health

Locations

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My Duc Hospital

Ho Chi Minh City, Ward 13. Tan Binh District, Vietnam

Site Status RECRUITING

Countries

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Vietnam

Central Contacts

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Tuong M Ho, Doctor

Role: CONTACT

+ 84 903633377

Anh H Dang, MSc.

Role: CONTACT

+84 908 302412

Facility Contacts

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Vinh Q Dang, MD

Role: primary

+84 908225481

Anh H Dang, MSc

Role: backup

+ 84 908302412

Other Identifiers

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NCKH/CGRH_08_2015

Identifier Type: -

Identifier Source: org_study_id

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