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A Case Control Study of Patients With Diagnosis of Malignant Hyperthermia

NCT ID: NCT02561598

Last Updated: 2022-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2023-05-31

Study Completion Date

2024-05-31

Brief Summary

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The purpose of the study is to develop methods to identify predictors of Malignant Hyperthermia.

Detailed Description

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The current study will use the combination of electronic medical records and genomic information in samples of persons who have exhibited signs of Malignant Hyperthermia (MH) or have family history or high risk of MH to see if risk factors can be identified. These will be compared with control samples of children who have been exposed to the same agents which could induce MH, yet showed no signs of the disorder.

Conditions

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Malignant Hyperthermia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Malignant Hyperthermia

Samples from persons who have a malignant hyperthermia diagnosis.

No interventions assigned to this group

Controls

Children who participated in pharmacogenetic research and had exposure to malignant hyperthermia triggering agents.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Malignant hyperthermia cases: Diagnosis of malignant hyperthermia
* Control cases: children who participated
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Children's Hospital Medical Center, Cincinnati

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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John McAuliffe, MD

Role: PRINCIPAL_INVESTIGATOR

Children's Hospital Medical Center, Cincinnati

Locations

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Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States

Site Status

Countries

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United States

Other Identifiers

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2014-2884

Identifier Type: -

Identifier Source: org_study_id