Cochlear Implantation for Treatment of Single-sided Deafness

NCT ID: NCT02532972

Last Updated: 2020-05-05

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: NA
• Total Enrollment: 11 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-09-30
• Study Completion Date: 2019-04-25

Brief Summary

This is a research study to determine whether a cochlear implantation (CI) device can improve hearing in people who are deaf in one ear (known as single-sided deafness).

Detailed Description

The goal of this study is to further investigate the role of CI in treating unilateral hearing loss and associated tinnitus. Single-sided deafness (SSD) afflicts approximately 60,000 new patients per year in the United States. The most common causes of these single-sided losses are sudden sensorineural hearing loss, Meniere's disease, trauma, and vestibular schwannoma. Patients with SSD face significant difficulty with communicating in the presence of background noise and in sound localization. Another significant problem for some SSD patients is tinnitus, which can be incapacitating and for which there are no therapies available that are considered to be of sufficient reliability to become a standard of care. Difficulty hearing in background noise and increased tinnitus can lead to significant frustration in social situations and contribute to increased isolation and a decreased quality of life. Treatment options for single sided deafness in the United States include contralateral routing of signals (CROS) hearing aids, bone-anchored hearing aids (BAHA) and use of assistive devices to improve the signal-to-noise in group situations. The first two devices take sound from the affected ear and transmit it to the unaffected ear. The last device consists of having a speaker wear a microphone and routing the signal directly to the patient's ear at a louder listening level. Although these devices can improve speech understanding in some patients, studies have shown that use of these devices does not ameliorate tinnitus or sound localization difficulties. Recent European studies have demonstrated that cochlear implantation (CI) can provide significant improvements in both perceived hearing ability and measured speech comprehension and localization in adult and pediatric patients with unilateral hearing loss. This suggests that CI may be a more effective option for this patient population than the CROS, BAHA or assistive devices.

Conditions

Total Unilateral Deafness; Unilateral Partial Deafness

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Cochlear Implant surgery

All subjects will be part of a single arm involving placement of the Med-El MAESTRO Cochlear Implant with Flex 28 electrode array

Group Type: EXPERIMENTAL

Med-el MAESTRO Cochlear Implant with Flex 28 electrode array

Intervention Type: DEVICE

Cochlear Implant (CI) surgery followed by device activation, testing, and clinical assessment for 12 months following surgery.

Interventions

Med-el MAESTRO Cochlear Implant with Flex 28 electrode array

Cochlear Implant (CI) surgery followed by device activation, testing, and clinical assessment for 12 months following surgery.

Intervention Type: DEVICE

Other Intervention Names

CI; cochlear implant

Eligibility Criteria

Inclusion Criteria

• 18 years of age or older with the ability to provide informed consent
• English as the primary language
• Medically and psychologically suitable
• Willing to receive/have received meningitis vaccinations
• Able to pay for all care received through the study, either through the subject's insurance company or through self-pay
• Able to comply with study requirements, including travel to the investigational sites
• Severe to profound sensorineural hearing loss (≥70 dB HL (decibel hearing level) thresholds between 500 and 4000 Hz) in the worse ear with ≤ 20% Consonant-Nucleus-Consonant (CNC) word scores
• Duration of single-sided deafness ≥ one year
• Tinnitus localized to the affected ear, both ears, or in the head localized to the affected ear, both ears, or in the head

• Expected subjects include those with:
• Unilateral hearing loss secondary to viral or bacterial infection, such as meningitis or labyrinthitis
• Ménière's disease
• Sudden sensorineural hearing loss
• Vascular disease affecting the inner ear
• A combination of any number of the above conditions

Exclusion Criteria

• Duration of single-sided deafness ≥ ten years
• Pure tone thresholds ≥ 35 dB HL at 500, 1000, 2000, and 4000 Hz in the better ear
• Consonant-Nucleus-Consonant (CNC) word scores ≤ 70% in the better ear
• Chronic otitis media in either ear
• Inner ear malformation in either ear
• Autoimmune inner ear disease (fluctuation sensorineural hearing loss in either ear)
• Evidence of retrocochlear pathology, including vestibular schwannoma
• Unilateral tinnitus in the unaffected ear
• Cochlear ossification
• Demonstrated cognitive and/or developmental challenges
• Major depression or anxiety; post-traumatic stress disorder; substance abuse
• Medical or psychological conditions that serve as contraindication to surgery
• Additional handicaps that would prevent or limit participation in evaluations
• Unrealistic patient or family expectations regarding the benefits, risks, and limitations inherent to the procedure and the prosthetic device
• Pregnant women: The investigators will specifically ask all women of childbearing age if there is a possibility they are pregnant or trying to become pregnant at the initial clinic visit; any women who are pregnant or actively trying to become pregnant will be excluded. In cases that are questionable on the day of planned surgery, a pregnancy test will be performed as per current Massachusetts Eye & Ear Infirmary anesthesia pre-operative protocols.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Wisconsin, Madison

OTHER

Sponsor Role: collaborator

Dr. Daniel Lee

OTHER

Sponsor Role: lead

Responsible Party

Dr. Daniel Lee

Director, Pediatric Otology and Neurotology

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Daniel J Lee, MD, FACS

Role: PRINCIPAL_INVESTIGATOR

MEEI / MGH

Locations

Massachusetts Eye and Ear Infirmary

Boston, Massachusetts, United States

Countries

United States

References

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Reference Type: BACKGROUND

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Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

13-054H

Identifier Type: -

Identifier Source: org_study_id