Study to Evaluate the Safety and Effectiveness of the CODMAN ENTERPRISE® Vascular Reconstruction Device

NCT ID: NCT02532517

Last Updated: 2020-10-23

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-09-01

Study Completion Date

2019-09-21

Brief Summary

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The purpose of this study is to demonstrate effectiveness and safety of the CODMAN ENTERPRISE® Vascular Reconstruction Device and Delivery System.

Detailed Description

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The study is a prospective, multi-center, single arm, clinical study to evaluate the safety and effectiveness of the ENTERPRISE stent when used in conjunction with endovascular coil embolization in the treatment of unruptured wide-neck, intracranial, saccular anterior circulation aneurysms (≤ 10 mm). The primary objectives of the study are to evaluate the rate of complete angiographic occlusion at 12 months.

Conditions

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Intracranial Aneurysm

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Enterprise

Group Type EXPERIMENTAL

CODMAN ENTERPRISE® Vascular Reconstruction Device and Delivery System

Intervention Type DEVICE

Interventions

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CODMAN ENTERPRISE® Vascular Reconstruction Device and Delivery System

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Target aneurysm is an unruptured wide-neck, intracranial, saccular anterior circulation aneurysm (≤ 10 mm) arising from a parent vessel with a diameter of ≥ 2.5 mm and ≤ 4 mm
* Subject understands the nature of the procedure and provides voluntary written informed consent prior to the treatment
* Subject is willing to comply with specified follow-up evaluation

Exclusion Criteria

* Planned staged procedure
* Currently enrolled in another investigational device or drug study
* Target aneurysm that has been previously treated
* Mycotic, fusiform or dissecting aneurysm
* Admission platelet \<50,000 or any known hemorrhagic diathesis, coagulation deficiency, or on oral anticoagulant therapy with an INR \>3.0
* A serum creatinine level \> 2.5 mg/dL within 7 days prior to index procedure
Minimum Eligible Age

21 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cerenovus, Part of DePuy Synthes Products, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Donald Frei, MD

Role: PRINCIPAL_INVESTIGATOR

Radiology Imaging Associates

Locations

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Radiology Imaging Associates

Englewood, Colorado, United States

Site Status

University of Florida

Gainesville, Florida, United States

Site Status

Lyerly Neurosurgery, an Affiliate of Baptist Health

Jacksonville, Florida, United States

Site Status

University of Illinois at Chicago

Chicago, Illinois, United States

Site Status

Johns Hopkins University

Baltimore, Maryland, United States

Site Status

University of Massachusetts Medical Center

Worcester, Massachusetts, United States

Site Status

University of Buffalo

Buffalo, New York, United States

Site Status

Mount Sinai Health System

New York, New York, United States

Site Status

Miami Valley Hospital

Dayton, Ohio, United States

Site Status

Lehigh Valley Health Network

Allentown, Pennsylvania, United States

Site Status

Inova Fairfax Hospital

Falls Church, Virginia, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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NV-IDE-1001

Identifier Type: -

Identifier Source: org_study_id

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