Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee

NCT ID: NCT02528188

Last Updated: 2020-01-10

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

3021 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-07-21

Study Completion Date

2019-02-27

Brief Summary

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The purpose of this study is to compare the long-term joint safety and efficacy (pain relief) of the investigational study drug, tanezumab compared to non-steroidal anti inflammatory drugs (NSAIDs) in subjects with osteoarthritis of the hips or knees.

Detailed Description

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Conditions

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Chronic Pain Osteoarthritis, Hip Osteoarthritis, Knee

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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NSAID

Subcutaneous injection of placebo for tanezumab every 8 weeks plus oral NSAID (naproxen 500 mg, celecoxib 100 mg or diclofenac 75 mg) twice daily for 56 weeks

Group Type ACTIVE_COMPARATOR

NSAID

Intervention Type DRUG

Orally administered NSAID (naproxen 500 mg, celecoxib 100 mg or diclofenac 75 mg) twice daily for 56 weeks

Tanezumab 2.5 mg

Subcutaneous injection of tanezumab 2.5 mg every 8 weeks plus oral placebo for NSAID (naproxen, celecoxib or diclofenac ER) twice daily for 56 weeks

Group Type EXPERIMENTAL

Tanezumab 2.5 mg

Intervention Type BIOLOGICAL

Subcutaneous injection of tanezumab 2.5 mg every 8 weeks for 56 weeks

Tanezumab 5 mg

Subcutaneous injection of tanezumab 5 mg every 8 weeks plus oral placebo for NSAID (naproxen, celecoxib or diclofenac) twice daily for 56 weeks

Group Type EXPERIMENTAL

Tanezumab 5 mg

Intervention Type BIOLOGICAL

Subcutaneous injection of tanezumab 5 mg every 8 weeks for 56 weeks

Interventions

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NSAID

Orally administered NSAID (naproxen 500 mg, celecoxib 100 mg or diclofenac 75 mg) twice daily for 56 weeks

Intervention Type DRUG

Tanezumab 2.5 mg

Subcutaneous injection of tanezumab 2.5 mg every 8 weeks for 56 weeks

Intervention Type BIOLOGICAL

Tanezumab 5 mg

Subcutaneous injection of tanezumab 5 mg every 8 weeks for 56 weeks

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* A diagnosis of osteoarthritis of the index hip or knee based on American College of Rheumatology criteria with Kellgren Lawrence X ray Grade of 2 as diagnosed by the Central Reader
* Currently receiving a stable dose regimen of oral NSAID (naproxen, celecoxib, diclofenac, aceclofenac, loxoprofen, ibuprofen, meloxicam, nabumetone, sulindac or ketoprofen) as described in the protocol along with a history of insufficient pain relief from, inability to tolerate or contraindication to taking acetaminophen and, tramadol or opioid treatments. Subjects must also maintain a stabilized, protocol specified NSAID dose regimen for at least the final 2 or 3 weeks of the Screening period
* WOMAC Pain subscale score of at least 5 in the index knee or hip at Screening
* Be willing to discontinue all non study pain medications for osteoarthritis and not use prohibited pain medications throughout the duration of the study
* Female subjects of childbearing potential must agree to comply with protocol specified contraceptive requirements

Exclusion Criteria

* Subjects exceeding protocol defined BMI or body weight limits
* History of other diseases specified in the protocol (eg, inflammatory joint diseases, crystalline diseases such as gout or pseudogout) that may involve the index joint and that could interfere with efficacy assessments
* Radiographic evidence of protocol specified bone or joint conditions in any screening radiograph as determined by the central radiology reviewer
* A history of osteonecrosis or osteoporotic fracture
* History of significant trauma or surgery to a knee, hip or shoulder within the previous year
* Planned surgical procedure during the duration of the study
* Presence of conditions (eg, fibromyaliga, radiculopathy) associated with moderate to severe pain that may confound assessments or self evaluation of osteoarthritis pain
* Signs or symptoms of carpal tunnel syndrome in the year prior to Screening
* Considered unfit for surgery based upon American Society of Anesthesiologists physical classification system for surgery grading, or subjects who would not be willing to undergo joint replacement surgery if required
* Contraindications to magnetic resonance imaging
* History of intolerance or hypersensitivity to the oral NSAID (naproxen, celecoxib or diclofenac) the subject could be randomized to receive or any of its excipients or existence of a medical condition or use of concomitant medication for which the use of this NSAID is contraindicated
* History of intolerance or hypersensitivity to acetaminophen or any of its excipients or existence of a medical condition or use of concomitant medication for which the use of acetaminophen is contraindicated
* Use of prohibited medications without the appropriate washout period prior to Screening or Initial Pain Assessment Period
* History of cancer within 5 years of Screening, except for cutaneous basal cell or squamous cell cancer resolved by excision
* Subjects with signs and symptoms of clinically significant cardiac disease as described in the protocol
* Diagnosis of a transient ischemic attack in the 6 months prior to Screening, diagnosis of stroke with residual deficits that would preclude completion of required study activities
* History, diagnosis, or signs and symptoms of clinically significant neurological disease such as but not limited to peripheral or autonomic neuropathy
* History, diagnosis, signs or symptoms of any clinically significant psychiatric disorder
* History of known alcohol, analgesic or drug abuse within 2 years of Screening
* Previous exposure to exogenous NGF or to an anti-NGF antibody
* History of allergic or anaphylactic reaction to a therapeutic or diagnostic monoclonal antibody or IgG fusion protein
* Poorly controlled hypertension as defined in the protocol or taking an antihypertensive that has not been stable for at least 1 month prior to Screening
* Evidence of protocol defined orthostatic hypotension at Screening
* Disqualifying score on the Survey of Autonomic Symptoms questionnaire at Screening
* Screening AST, ALT, serum creatinine or HbA1c values that exceed protocol defined limits
* Presence of drugs of abuse in screening urine toxicology panel
* Positive hepatitis B, hepatitis C or HIV test results indicative of current infection
* Participation in other investigational drug studies within protocol defined time limits
* Pregnant, breastfeeding or female subjects of childbearing potential who are unwilling or unable to follow protocol required contraceptive requirements
* Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that in the judgment of the investigator, would make the subject inappropriate for entry into this study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Central Alabama Research

Birmingham, Alabama, United States

Site Status

Achieve Clinical Research, LLC

Birmingham, Alabama, United States

Site Status

Alabama Clinical Therapeutics, LLC

Birmingham, Alabama, United States

Site Status

Alabama Orthopaedic Surgeons

Birmingham, Alabama, United States

Site Status

Rheumatology Associates of North Alabama, PC

Huntsville, Alabama, United States

Site Status

Coastal Clinical Research, Inc.

Mobile, Alabama, United States

Site Status

Ferguson Family Medicine

Mesa, Arizona, United States

Site Status

Arizona Arthritis & Rheumatology Associates, P.C.

Phoenix, Arizona, United States

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Arizona Research Center

Phoenix, Arizona, United States

Site Status

Valley Pain Consultants

Scottsdale, Arizona, United States

Site Status

Clinical Research Consortium

Tempe, Arizona, United States

Site Status

Noble Clinical Research, LLC

Tucson, Arizona, United States

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Quality of Life Medical & Research Centers, LLC

Tucson, Arizona, United States

Site Status

Tucson Orthopaedic Institute - Research Center

Tucson, Arizona, United States

Site Status

CHI St. Vincent Medical Group Hot Springs

Hot Springs, Arkansas, United States

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Chrystal Johnson

Little Rock, Arkansas, United States

Site Status

KLR Business Group, Inc., dba Arkansas Clinical Research

Little Rock, Arkansas, United States

Site Status

Larry Watkins, MD

Little Rock, Arkansas, United States

Site Status

Lynn Institute of the Ozarks

Little Rock, Arkansas, United States

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Orange County Research Institute

Anaheim, California, United States

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Advanced Research Center

Anaheim, California, United States

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CITrials

Bellflower, California, United States

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Osteoporosis Medical Center

Beverly Hills, California, United States

Site Status

Hope Clinical Research

Canoga Park, California, United States

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Med Center

Carmichael, California, United States

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Core Healthcare Group

Cerritos, California, United States

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Pleitez Medical Clinic

Covina, California, United States

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Triwest Research Associates, LLC

El Cajon, California, United States

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T. Joseph Raoof MD, INC/Encino Research Center

Encino, California, United States

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San Diego Imaging Escondido

Escondido, California, United States

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Med Investigations, Inc.

Fair Oaks, California, United States

Site Status

Research Center of Fresno, Inc.

Fresno, California, United States

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Neuro-Pain Medical Center

Fresno, California, United States

Site Status

Collaborative Neuroscience Network, LLC.

Garden Grove, California, United States

Site Status

Allied Clinical Research

Gold River, California, United States

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HealthCare Partners Clinical Research, LLC.

Huntington Beach, California, United States

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Marvel Clinical Research LLC

Huntington Beach, California, United States

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BioSolutions Clinical Research Center

La Mesa, California, United States

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eStudySite

La Mesa, California, United States

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Arthritis & Osteoporosis Medical Center

La Palma, California, United States

Site Status

Center For United Research, Inc.

Lakewood, California, United States

Site Status

Collaborative Neuroscience Network, LLC.

Long Beach, California, United States

Site Status

Aeon Research, Inc.

Los Angeles, California, United States

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American Institute of Research

Los Angeles, California, United States

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InterMed Medical Group

Los Angeles, California, United States

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IMD Medical Group

Los Angeles, California, United States

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Catalina Research Institute, LLC

Montclair, California, United States

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Providence Clinical Research

North Hollywood, California, United States

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Renaissance Imaging Medical Associates, Inc

Northridge, California, United States

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NRC Research Institute

Orange, California, United States

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Advances in Medicine

Palm Desert, California, United States

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Probe Clinical Research Corporation

Riverside, California, United States

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University of California, Davis Health System

Sacramento, California, United States

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University of California, Davis Medical Center

Sacramento, California, United States

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Clinical Trials Research

Sacramento, California, United States

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Northern California Research

Sacramento, California, United States

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Center for Clinical Trials of Sacramento, Inc.

Sacramento, California, United States

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Artemis Institute for Clinical Research

San Diego, California, United States

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San Diego Imaging, Kearny Mesa

San Diego, California, United States

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Sharp and Children's MRI Center, LLC

San Diego, California, United States

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Artemis Institute for Clinical Research

San Marcos, California, United States

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CITrials

Santa Ana, California, United States

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Syrentis Clinical Research

Santa Ana, California, United States

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Shariar Cohen, MD Corp.

Thousand Oaks, California, United States

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Westlake Medical Research

Thousand Oaks, California, United States

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Bayview Research Group

Valley Village, California, United States

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Renaissance Imaging Medical Associates, Inc

Van Nuys, California, United States

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Buhay & Maglunog MDS

West Covina, California, United States

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Prohealth Advanced Imaging

West Hills, California, United States

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Advanced Rx Clinical Research Group, Inc

Westminster, California, United States

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Medvin Clinical Research

Whittier, California, United States

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Elite Clinical Trials

Wildomar, California, United States

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Mountain View Clinical Research, Inc.

Denver, Colorado, United States

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Mountain View Clinical Research, Inc

Denver, Colorado, United States

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New England Research Associates, LLC

Bridgeport, Connecticut, United States

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Clinical Research Center of CT

Danbury, Connecticut, United States

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Stamford Therapeutics Consortium

Stamford, Connecticut, United States

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Delaware Arthritis

Lewes, Delaware, United States

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Javed Rheumatology Associates, Inc.

Newark, Delaware, United States

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JEM Research Institute

Atlantis, Florida, United States

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AARDS Research, Inc.

Aventura, Florida, United States

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RASF-Clinical Research, Inc

Boca Raton, Florida, United States

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Orthopedic Research Institute

Boynton Beach, Florida, United States

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Meridien Research

Brooksville, Florida, United States

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Orthopaedic Associates of West Florida

Clearwater, Florida, United States

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Tampa Bay Medical Research, Inc

Clearwater, Florida, United States

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Midland Florida Clinical Research Center, LLC

DeLand, Florida, United States

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S&W Clinical Research

Fort Lauderdale, Florida, United States

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Centre for Rheumatology, Immunology and Arthritis

Fort Lauderdale, Florida, United States

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Clinical Physiology Associates

Fort Myers, Florida, United States

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IMA

Fort Myers, Florida, United States

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SIMEDHealth, LLC

Gainesville, Florida, United States

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South Florida Clinical Trials

Hialeah, Florida, United States

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Pines Clinical Research Inc.

Hollywood, Florida, United States

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Jacksonville Center for Clinical Research

Jacksonville, Florida, United States

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Care Partners Clinical Research

Jacksonville, Florida, United States

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Clinical Neuroscience Solutions, Inc.

Jacksonville, Florida, United States

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Columbus Clinical Services LLC

Miami, Florida, United States

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Pharmax Research Clinic, Inc.

Miami, Florida, United States

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Clintex Research Group

Miami, Florida, United States

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Center for Arthritis and Rheumatic Diseases

Miami, Florida, United States

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Larkin Imaging Center

Miami, Florida, United States

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New Horizon Research Center

Miami, Florida, United States

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International Research Associates, LLC

Miami, Florida, United States

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M&M Medical Center, Inc.

Miami, Florida, United States

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Quality Research & Medical Center LLC

Miami, Florida, United States

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Renstar Medical Research

Ocala, Florida, United States

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American Family Medical

Ocala, Florida, United States

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Sensible Healthcare, LLC.

Ocoee, Florida, United States

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Journey Research, Inc.

Oldsmar, Florida, United States

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Sunshine Research Center

Opa-locka, Florida, United States

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Compass Research, LLC

Orlando, Florida, United States

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Rheumatology Associates of Central Florida, P.A.

Orlando, Florida, United States

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Omega Research Consultants, LLC

Orlando, Florida, United States

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Oviedo Medical Research, LLC

Oviedo, Florida, United States

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Pensacola Research Consultants, Inc., d.b.a. Avanza Medical Research Center

Pensacola, Florida, United States

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Sacred Heart Orthopedics

Pensacola, Florida, United States

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Orthopaedic Center of South Florida

Plantation, Florida, United States

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St. Johns Center for Clinical Research

Ponte Vedra, Florida, United States

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Progressive Medical Research

Port Orange, Florida, United States

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Accord Clinical Research, LLC

Port Orange, Florida, United States

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Gulfcoast Research Institute, LLC

Sarasota, Florida, United States

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Kennedy White Orthopaedic Center

Sarasota, Florida, United States

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Meridien Research

St. Petersburg, Florida, United States

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Precision Clinical Research, LLC.

Sunrise, Florida, United States

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Phoenix Clinical Research, LLC.

Tamarac, Florida, United States

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Clinical Research of West Florida, Inc.

Tampa, Florida, United States

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Stedman Clinical Trials

Tampa, Florida, United States

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BayCare Medical Group, Inc

Tampa, Florida, United States

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Compass Research North LLC

The Villages, Florida, United States

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Palm Beach Research Center

West Palm Beach, Florida, United States

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Atlanta Center for Medical Research

Atlanta, Georgia, United States

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Perimeter Institute for Clinical Research, Inc. DBA:/PICR Clinic

Atlanta, Georgia, United States

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Masters of Clinical Research, Inc.

Augusta, Georgia, United States

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River Birch Research Alliance, LLC

Blue Ridge, Georgia, United States

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Arthritis Center of North Georgia

Gainesville, Georgia, United States

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Center for Advanced Research & Education

Gainesville, Georgia, United States

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Drug Studies America

Marietta, Georgia, United States

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Better Health Clinical Research, Inc.

Newnan, Georgia, United States

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Atlanta Orthopaedic Institute, LLC

Stockbridge, Georgia, United States

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Herman Clinical Research, LLC

Suwanee, Georgia, United States

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North Georgia Clinical Research

Woodstock, Georgia, United States

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North Georgia Internal Medicine

Woodstock, Georgia, United States

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East-West Medical Research Institute

Honolulu, Hawaii, United States

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Idaho Sports Medicine Institute

Boise, Idaho, United States

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Injury Care Research, LLC

Boise, Idaho, United States

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Institute Of Arthritis Research

Idaho Falls, Idaho, United States

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Advanced Clinical Research

Meridian, Idaho, United States

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Medex Healthcare Research, Inc.

Chicago, Illinois, United States

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Chicago Clinical Research Institute Inc.

Chicago, Illinois, United States

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Northwestern Memorial Hospital-Arkes Pavilion, Diagnostic Testing Center

Chicago, Illinois, United States

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Northwestern University Feinberg School of Medicine

Chicago, Illinois, United States

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Rush University Medical Center

Chicago, Illinois, United States

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Great Lakes Clinical Trials

Chicago, Illinois, United States

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Affinity Clinical Research Institute

Oak Lawn, Illinois, United States

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Southwest Center for Healthy Joints, S.C.

Oak Lawn, Illinois, United States

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Methodist Research Administration Office

Peoria, Illinois, United States

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UnityPoint Clinic Rheumatology

Peoria, Illinois, United States

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Methodist Medical Center of Illinois

Peoria, Illinois, United States

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OrthoIllinois

Rockford, Illinois, United States

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Quest Diagnostics

Rockford, Illinois, United States

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MediSphere Medical Research Center, LLC

Evansville, Indiana, United States

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Buynak Clinical Research, P.C.

Valparaiso, Indiana, United States

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Mid-America Physiatrists, P.A.

Overland Park, Kansas, United States

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Phoenix Medical Research, Inc.

Prairie Village, Kansas, United States

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Professional Research Network of Kansas, LLC

Wichita, Kansas, United States

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Heartland Research Associates, LLC

Wichita, Kansas, United States

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Otrimed Corporation

Edgewood, Kentucky, United States

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Central Kentucky Research Associates, Inc.

Lexington, Kentucky, United States

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Baton Rouge General Medical Center-Internal Medicine Clinic

Baton Rouge, Louisiana, United States

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Baton Rouge General Medical Center-Midcity

Baton Rouge, Louisiana, United States

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Baton Rouge General Medical Center-Bluebonnet

Baton Rouge, Louisiana, United States

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Baton Rouge General Medical Center-Clinical Trials Office

Baton Rouge, Louisiana, United States

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Centex Studies, Inc.

Lake Charles, Louisiana, United States

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Klein & Associates, M.D., P.A.

Cumberland, Maryland, United States

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Arthritis Treatment Center

Frederick, Maryland, United States

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Klein & Associates, M.D., P.A.

Hagerstown, Maryland, United States

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The Center for Rheumatology and Bone Research

Wheaton, Maryland, United States

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Beacon Clinical Research, LLC

Quincy, Massachusetts, United States

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MedVadis Research Corporation

Watertown, Massachusetts, United States

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Great Lakes Research Group, Incorporated

Bay City, Michigan, United States

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Onyx Clinical Research

Caro, Michigan, United States

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Orthopaedic Associates of Michigan, PC

Grand Rapids, Michigan, United States

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June D.O. PC

Lansing, Michigan, United States

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Great Lakes Research Group

Pinconning, Michigan, United States

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Michigan Orthopaedic Spine Surgeons

Rochester Hills, Michigan, United States

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Medical Research Associates Inc.

Traverse City, Michigan, United States

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Oakland Medical Research Center

Troy, Michigan, United States

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Olive Branch Family Medical Center

Olive Branch, Mississippi, United States

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Landmark Internal Medicine

Southaven, Mississippi, United States

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University of Missouri Health Care-Investigational Pharmacy

Columbia, Missouri, United States

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University of Missouri Health Care

Columbia, Missouri, United States

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University of Missouri School of Medicine- Clinical Research Center

Columbia, Missouri, United States

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Advance Clinical Research, Inc.

St Louis, Missouri, United States

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Medex Healthcare Research, Inc.

St Louis, Missouri, United States

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Physician Research Collaboration, LLC

Lincoln, Nebraska, United States

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Affiliated Clinical Research, Inc.

Las Vegas, Nevada, United States

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Impact Clinical Trials

Las Vegas, Nevada, United States

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Office of Stephen H. Miller, MD

Las Vegas, Nevada, United States

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Clinical Research Consortium

Las Vegas, Nevada, United States

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Office of Robert P. Kaplan, DO

Las Vegas, Nevada, United States

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Advanced Biomedical Research of America

Las Vegas, Nevada, United States

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G. Timothy Kelly, MD

Las Vegas, Nevada, United States

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ActivMed Practices & Research, Inc.

Portsmouth, New Hampshire, United States

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Ocean Rheumatology, PA

Toms River, New Jersey, United States

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Premier Research

Trenton, New Jersey, United States

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Arthritis, Rheumatic and Back Disease Associates, PA

Voorhees Township, New Jersey, United States

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Albuquerque Clinical Trials, Inc.

Albuquerque, New Mexico, United States

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New Mexico Clinical Research & Osteoporosis Center, Inc.

Albuquerque, New Mexico, United States

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Lovelace Scientific Resources Inc.

Albuquerque, New Mexico, United States

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NYU Langone Ambulatory Care Brooklyn Heights

Brooklyn, New York, United States

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Drug Trials Brooklyn

Brooklyn, New York, United States

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SPRI Clinical Trials, LLC

Brooklyn, New York, United States

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Drug Trials America

Hartsdale, New York, United States

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NYU Langone Arena Oncology, Laura and Issac Perlmutter Cancer Center, Infusion Center

Lake Success, New York, United States

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NYU Langone Arena Oncology, Laura and Issac Perlmutter Cancer Center

Lake Success, New York, United States

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NYU Langone Rheumatology Associates Long Island

Lake Success, New York, United States

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Lenox Hill Radiology

New York, New York, United States

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Manhattan Medical Research Practice PLLC

New York, New York, United States

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The Medical Research Network, LLC

New York, New York, United States

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AAIR Research Center

Rochester, New York, United States

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Upstate Clinical Research Associates, LLC

Williamsville, New York, United States

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Northstate Clinical Research, PLLC

Lenoir, North Carolina, United States

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Wake Internal Medicine Consultants, Inc

Raleigh, North Carolina, United States

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Wake Research Associates, LLC

Raleigh, North Carolina, United States

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The Center for Clinical Research

Winston-Salem, North Carolina, United States

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Lillestol Research, LLC

Fargo, North Dakota, United States

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Plains Clinical Research Center, LLC

Fargo, North Dakota, United States

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Valley Medical Research/Valley Medical Primary Care

Centerville, Ohio, United States

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Hightop Medical Research Center

Cincinnati, Ohio, United States

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New Horizons Clinical Research

Cincinnati, Ohio, United States

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CTI Clinical Research Center

Cincinnati, Ohio, United States

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Aventiv Research Inc.

Columbus, Ohio, United States

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Remington-Davis, Incorporated

Columbus, Ohio, United States

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Optimed Research LTD

Columbus, Ohio, United States

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Dayton Clinical Research

Dayton, Ohio, United States

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PriMed Clinical Research

Dayton, Ohio, United States

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Kettering Medical Center

Kettering, Ohio, United States

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Springboro Health Center

Springboro, Ohio, United States

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AC Clinical Research

Tiffin, Ohio, United States

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Glendale Medical Center

Toledo, Ohio, United States

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Bone Joint & Spine Surgeons, Inc.

Toledo, Ohio, United States

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Health Research of Oklahoma

Oklahoma City, Oklahoma, United States

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Lynn Health Science Institute

Oklahoma City, Oklahoma, United States

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University Orthopedics Center

Altoona, Pennsylvania, United States

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Heritage Valley Medical Group, Inc.

Beaver, Pennsylvania, United States

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Brandywine Clinical Research

Downingtown, Pennsylvania, United States

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Altoona Center for Clinical Research

Duncansville, Pennsylvania, United States

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The Clinical Trial Center LLC

Jenkintown, Pennsylvania, United States

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Founders Research Corporation

Philadelphia, Pennsylvania, United States

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The Arthritis Group

Philadelphia, Pennsylvania, United States

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Clinical Research Center of Reading, LLC

Wyomissing, Pennsylvania, United States

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Main Street Physician's Care - Waterway

Little River, South Carolina, United States

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Main Street Physician's Care - Loris

Loris, South Carolina, United States

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North Myrtle Beach Family Practice

North Myrtle Beach, South Carolina, United States

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Clinical Research Solutions

Jackson, Tennessee, United States

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Physicians Quality Care

Jackson, Tennessee, United States

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PMG Research, Inc. d/b/a PMG Research of Knoxville

Jefferson City, Tennessee, United States

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PCET Research Center, LLC

Knoxville, Tennessee, United States

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Diagnostic Imaging PC

Memphis, Tennessee, United States

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ARC Clinical Research at Wilson Parke

Austin, Texas, United States

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Tekton Research, Inc.

Austin, Texas, United States

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Urgent Care MD's

Baytown, Texas, United States

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Texas Orthopedic Specialists, PLLC

Bedford, Texas, United States

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Galenos Research

Dallas, Texas, United States

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Abigail R. Neiman, MD, PA

Houston, Texas, United States

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Advances in Health

Houston, Texas, United States

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Mercury Clinical Research, Inc.

Houston, Texas, United States

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Centex Studies, Inc.

Houston, Texas, United States

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Memorial Pulmonology

Houston, Texas, United States

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BI Research Center

Houston, Texas, United States

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Clinical Investigations of Texas

Plano, Texas, United States

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ClinRX Research

Richardson, Texas, United States

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Quality Research, Inc.

San Antonio, Texas, United States

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Lee Medical Associates PA

San Antonio, Texas, United States

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Progressive Clinical Research, PA

San Antonio, Texas, United States

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Sun Research Institute

San Antonio, Texas, United States

Site Status

Panacea Clinical Research

San Antonio, Texas, United States

Site Status

Accurate Clinical Research Inc.

San Antonio, Texas, United States

Site Status

Diagnostics Research Group

San Antonio, Texas, United States

Site Status

Victorium Clinical Research

San Antonio, Texas, United States

Site Status

DCT-Stone Oak, LLC dba Discovery Clinical Trials

San Antonio, Texas, United States

Site Status

South Texas Radiology Imaging Centers

San Antonio, Texas, United States

Site Status

Envision Imaging

Southlake, Texas, United States

Site Status

Oakbend Medical Center

Sugar Land, Texas, United States

Site Status

ClinPoint Trials

Waxahachie, Texas, United States

Site Status

Mercury Clinical Research

Webester, Texas, United States

Site Status

Clinics of North Texas

Wichita Falls, Texas, United States

Site Status

Grayline Clinical Drug Trials

Wichita Falls, Texas, United States

Site Status

Granger Medical Clinic-Riverton

Riverton, Utah, United States

Site Status

Millennium Clinical Trials, LLC

Arlington, Virginia, United States

Site Status

Charlottesville Medical Research Center, LLC

Charlottesville, Virginia, United States

Site Status

Millennium Clinical Trials

Fairfax, Virginia, United States

Site Status

National Clinical Research-Norfolk, Inc.

Norfolk, Virginia, United States

Site Status

Northwest Clinical Research Center

Bellevue, Washington, United States

Site Status

Optimed Research, LTD

Bellingham, Washington, United States

Site Status

Swedish Medical Center Investigational Drug Services Pharmacy

Seattle, Washington, United States

Site Status

Seattle Rheumatology Associates

Seattle, Washington, United States

Site Status

Swedish Medical Center

Seattle, Washington, United States

Site Status

Genesis Research Services

Broadmeadow, New South Wales, Australia

Site Status

Hunter Imaging Group

Cardiff, New South Wales, Australia

Site Status

Optimus Clinical Research Pty Ltd

Kogarah, New South Wales, Australia

Site Status

Southern Radiology

Miranda, New South Wales, Australia

Site Status

Royal Hospital for Women

Randwick, New South Wales, Australia

Site Status

Castlereagh Imaging

St Leonards, New South Wales, Australia

Site Status

Royal North Shore Hospital

St Leonards, New South Wales, Australia

Site Status

Australian Clinical Research Network

Sydney, New South Wales, Australia

Site Status

Spectrum Medical Imaging

Sydney, New South Wales, Australia

Site Status

AusTrials Pty Ltd

Sherwood, Queensland, Australia

Site Status

CMAX Clinical Research Pty Ltd

Adelaide, South Australia, Australia

Site Status

Royal Adelaide Hospital Pharmacy

Adelaide, South Australia, Australia

Site Status

Bensons Radiology

North Adelaide, South Australia, Australia

Site Status

Emeritus Research

Camberwell, Victoria, Australia

Site Status

Capital Radiology-Malvern

Melbourne, Victoria, Australia

Site Status

Capital Radiology-Clayton

Melbourne, Victoria, Australia

Site Status

SKG Radiology Hollywood

Nedlands, Western Australia, Australia

Site Status

RK Will Pty Ltd

Victoria Park, Western Australia, Australia

Site Status

CMIP-Centro Mineiro de Pesquisa LTDA

Juiz de Fora, Minas Gerais, Brazil

Site Status

CCBR - Centro de Pesquisas e Analises Clinicas LTDA

Rio de Janeiro, Rio de Janeiro, Brazil

Site Status

CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda

São Paulo, São Paulo, Brazil

Site Status

Diagnostic Consultative Center "Sveti Georgi" EOOD

Plovdiv, , Bulgaria

Site Status

Medical Center "Health for all" - EOOD

Plovdiv, , Bulgaria

Site Status

UMHAT Kaspela - EOOD Rheumatology Clinic

Plovdiv, , Bulgaria

Site Status

UMHAT Kaspela - EOOD

Plovdiv, , Bulgaria

Site Status

"Medical Center Teodora" EOOD

Rousse, , Bulgaria

Site Status

Diagnostic Consultative Center 17 Sofia EOOD

Sofia, , Bulgaria

Site Status

UMHAT Sveti Ivan Rilski- EAD

Sofia, , Bulgaria

Site Status

UMHAT "Sofiamed" OOD, Block 2

Sofia, , Bulgaria

Site Status

"Medical Center- Dr. Hayvazov" EOOD

Sofia, , Bulgaria

Site Status

Centro Integral de Reumatologia Reumalab S.A.S.

Medellín, Antioquia, Colombia

Site Status

Centro de Investigacion en Reumatologia y Especialidades Medicas SAS CIREEM SAS

Bogotá, Bogota DC, Colombia

Site Status

Medicinski centar Kuna&Peric

Zagreb, , Croatia

Site Status

National Hospital Organization Toyohashi Medical Center

Toyohashi, Aichi-ken, Japan

Site Status

Funabashi Municipal Medical Center

Funabashi, Chiba, Japan

Site Status

Matsudo City General Hospital

Matsudo, Chiba, Japan

Site Status

Kanbara Clinic

Kitakyushu, Fukuoka, Japan

Site Status

Hidaka Orthopedic Hospital

Kurume, Fukuoka, Japan

Site Status

Obase Hospital

Miyako-gun, Fukuoka, Japan

Site Status

Himeno Hospital

Yamegun, Fukuoka, Japan

Site Status

Ikeda Kinen Hospital

Sukagawa, Fukushima, Japan

Site Status

Zenshukai Hospital

Maebashi, Gunma, Japan

Site Status

Mazda Hospital

Aki-gun, Hiroshima, Japan

Site Status

Medical Corporation Okimoto Clinic

Kure, Hiroshima, Japan

Site Status

Medical Corporation Emu Emukai, Matterhorn Rehabilitation Hospital

Kure, Hiroshima, Japan

Site Status

Takahashi Orthopedics Clinic

Chitose, Hokkaido, Japan

Site Status

Obihiro Orthopaedic Hospital

Obihiro, Hokkaido, Japan

Site Status

Okubo Hospital

Akashi, Hyōgo, Japan

Site Status

Omuro Orthopedic Clinic

Himeji, Hyōgo, Japan

Site Status

Medical corporate corporation hoshikai Onishi medical clinic

Kako-gun, Hyōgo, Japan

Site Status

Kobe Red Cross Hospital

Kobe, Hyōgo, Japan

Site Status

Mito Saiseikai General Hospital

Mito, Ibaraki, Japan

Site Status

National Hospital Organization Kanazawa Medical Center

Kanazawa, Ishikawa-ken, Japan

Site Status

Kokan Clinic

Kawasaki, Kanagawa, Japan

Site Status

Misugikai Medical Corporation Otokoyama Hospital

Yawata, Kyoto, Japan

Site Status

Nakajo Orthopedic Clinic

Sendai, Miyagi, Japan

Site Status

Marunouchi Hospital

Matsumoto, Nagano, Japan

Site Status

Oita University Hospital

Yufu, Oita Prefecture, Japan

Site Status

Sobajima Clinic/Orthopedics

Higashiosaka, Osaka, Japan

Site Status

Rinku General Medical Center

Izumisano, Osaka, Japan

Site Status

Kishiwada Tokushukai Hospital

Kishiwada, Osaka, Japan

Site Status

Social Welfare Organization Saiseikai Imperial Gift Foundation,Inc. Osaka Saiseikai Nakatsu Hospital

Osaka, Osaka, Japan

Site Status

Osaka University Hospital

Suita, Osaka, Japan

Site Status

Shimane University Hospital

Izumo, Shimane, Japan

Site Status

Fujieda Municipal General Hospital

Fujieda, Shizuoka, Japan

Site Status

JA Shizuoka Kohseiren Enshu Hospital

Hamamatsu, Shizuoka, Japan

Site Status

Japanese Red Cross Hamamatsu Hospital

Hamamatsu, Shizuoka, Japan

Site Status

Sonodakai Joint Replacement Center Hospital

Adachi-ku, Tokyo, Japan

Site Status

Medical Plaza Edogawa

Edogawa-ku, Tokyo, Japan

Site Status

Sato Orthopaedic Clinic

Edogawa-ku, Tokyo, Japan

Site Status

Fussa Hospital

Fussa, Tokyo, Japan

Site Status

Jukoukai hospital

Koto-ku, Tokyo, Japan

Site Status

Kitasato University Kitasato Institute Hospital

Minato-ku, Tokyo, Japan

Site Status

Tamagawa Hospital

Setagaya-ku, Tokyo, Japan

Site Status

Kohno Clinical Medicine Research Institute Daisan Kitashinagawa Hospital

Shinagawa-ku, Tokyo, Japan

Site Status

Ohimachi Orthopaedic Clinic

Shinagawa-ku, Tokyo, Japan

Site Status

Japan Organization of Occupational Health and Safety Sanin Rosai Hospital

Yonago, Tottori, Japan

Site Status

National Hospital Organization Chiba Medical Center

Chiba, , Japan

Site Status

Chihaya Hospital

Fukuoka, , Japan

Site Status

Kuroda Orthopedic Hospital

Fukuoka, , Japan

Site Status

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital

Hiroshima, , Japan

Site Status

Hiroshima Prefectural Hospital

Hiroshima, , Japan

Site Status

Kumamoto Orthopaedic Hospital

Kumamoto, , Japan

Site Status

Nagayoshi General Hospital

Osaka, , Japan

Site Status

Iwasaki Orthopedic Surgery

Saitama, , Japan

Site Status

Saitama Municipal Hospital

Saitama, , Japan

Site Status

Saules seimos medicinos centras

Kaunas, , Lithuania

Site Status

Klaipeda University Hospital

Klaipėda, , Lithuania

Site Status

Republican Siauliai Hospital

Šiauliai, , Lithuania

Site Status

Centro Hospitalario Mac, S.A. de C.V.

Guadajara, Jalisco, Mexico

Site Status

Consultorio Medico del Dr. Federico Galvan Villegas

Guadalajara, Jalisco, Mexico

Site Status

Lakeland Clinical Trials

Rotorua, BOP, New Zealand

Site Status

Otago Radiology

Dunedin, Otago, New Zealand

Site Status

RMC Medical Research Ltd

Dunedin, Otago, New Zealand

Site Status

South Pacific Clinical Trials

Auckland, , New Zealand

Site Status

TRG Imaging Lincoln Road

Auckland, , New Zealand

Site Status

Auckland Bone Density Ltd

Auckland, , New Zealand

Site Status

North Shore Hospital, Waitemata District Health Board

Auckland, , New Zealand

Site Status

Star Unit, North Shore Hospital, Waitemata District Health Board

Auckland, , New Zealand

Site Status

The Radiology Group

Auckland, , New Zealand

Site Status

Southern Clinical Trials- Waitemata Ltd

Auckland, , New Zealand

Site Status

Auckland Bone Density

Auckland, , New Zealand

Site Status

Optimal Clinical Trials

Auckland, , New Zealand

Site Status

Auckland Radiology Parnell Branch

Auckland, , New Zealand

Site Status

Southern Clinical Trials Ltd

Christchurch, , New Zealand

Site Status

Collingwood Street Pharmacy

Nelson, , New Zealand

Site Status

Nelson Radiology

Nelson, , New Zealand

Site Status

Porter Rheumatology Ltd

Nelson, , New Zealand

Site Status

Bay Radiology

Tauranga, , New Zealand

Site Status

P3 Research Ltd

Tauranga, , New Zealand

Site Status

Clinical Horizons NZ Ltd

Tauranga, , New Zealand

Site Status

P3 Research Ltd

Wellington, , New Zealand

Site Status

Pacific Radiology

Wellington, , New Zealand

Site Status

Unidad de Investigacion en Medicina Interna y Enfermedades criticas-Hogar Clinica San Juan de Dios

Cayma, Arequipa, Peru

Site Status

Centro De Investigacion Clinica Trujillo EIRL/Clinica Peruano Americana S.A.

Trujillo, La Libertad, Peru

Site Status

ABK REUMA S.R.L. de Medicentro Biociencias/BIO CIENCIAS PERU S.R.L.

Lima, , Peru

Site Status

Centro de Investigación Reumatología CAA-Clinica Anglo Americana

Lima, , Peru

Site Status

Investigaciones en Reumatologia / Centro Medico Corpac S.A.

Lima, , Peru

Site Status

Centro de Investigaciones Medicas-Hospital Maria Auxiliadora

Lima, , Peru

Site Status

Investigaciones Clinicas S.A.C. / Instituto de Ginecologia y Reproduccion S.A.

Lima, , Peru

Site Status

Investigaciones Clinicas S.A.C./Instituto de Ginecologia y Reproduccion S.A.

Lima, , Peru

Site Status

Philippine General Hospital

Manila, NCR, Philippines

Site Status

Manila Doctors Hospital

Manila, , Philippines

Site Status

Moscow Municipal Rheumatology Center

Moscow, , Russia

Site Status

SBHI "City Clinical Hospital No. 1 n.a N.I. Pirogov"

Moscow, , Russia

Site Status

SBHI "City Clinical Hospital No. 1 n.a. N.I. Pirogov"

Moscow, , Russia

Site Status

Federal State Budgetary Scientific Research institution of fundamental and clinical immunology

Novosibirsk, , Russia

Site Status

Federal State Budgetary Scientific Institution

Novosibirsk, , Russia

Site Status

State Budgetary Institution of Ryazan Region

Ryazan, , Russia

Site Status

Medical Technologies Ltd

Saint Petersburg, , Russia

Site Status

Limited Liability Company "Medical Center "Reavita Med SPb"

Saint Petersburg, , Russia

Site Status

Medinet LLC

Saint Petersburg, , Russia

Site Status

FSBI 'SRITO n.a. R.R. Vreden' MoH RF

Saint Petersburg, , Russia

Site Status

Institute for Rehabilitation

Belgrade, , Serbia

Site Status

Institute of Rheumatology

Belgrade, , Serbia

Site Status

Institute for treatment and rehabilitation "Niska Banja"

Niška Banja, , Serbia

Site Status

Special Hospital for Rheumatic Diseases Novi Sad

Novi Sad, , Serbia

Site Status

General hospital "Dr Laza K. Lazarevic" Sabac

Šabac, , Serbia

Site Status

Reumatologia s.r.o.

Bratislava, , Slovakia

Site Status

Nestatna Reumatologicka Ambulancia, Poliklinika Karlova Ves

Bratislava, , Slovakia

Site Status

MUDr. STRANAI s.r.o.

Košice, , Slovakia

Site Status

Reum.hapi s.r.o.

Nové Mesto nad Váhom, , Slovakia

Site Status

MEDIPA s.r.o.

Piešťany, , Slovakia

Site Status

Thermium s.r.o.

Piešťany, , Slovakia

Site Status

Daegu Catholic University Medical Center

Daegu, , South Korea

Site Status

Department of Radiology

Daegu, , South Korea

Site Status

Division of Rheumatology, Department of Internal Medicine, Daegu Catholic University Medical Center

Daegu, , South Korea

Site Status

Chungnam National University Hospital

Daejeon, , South Korea

Site Status

Clinical Trial Center Pharmacy

Daejeon, , South Korea

Site Status

Department of Radiology

Daejeon, , South Korea

Site Status

Chonnam National University Hospital

Gwangju, , South Korea

Site Status

Department of Radiology

Gwangju, , South Korea

Site Status

Pharmacy of Clinical Trial Center

Gwangju, , South Korea

Site Status

Clinical Trial Pharmacy

Seoul, , South Korea

Site Status

Department of Radiology

Seoul, , South Korea

Site Status

Korea University Anam Hospital

Seoul, , South Korea

Site Status

Clinical Trials Center Pharmacy

Seoul, , South Korea

Site Status

Seoul National University Hospital

Seoul, , South Korea

Site Status

Clinical Trial Center Pharmacy

Seoul, , South Korea

Site Status

Department of Radiology

Seoul, , South Korea

Site Status

Yonsei University Health System, Severance Hospital

Seoul, , South Korea

Site Status

Clinical Research Pharmacy

Seoul, , South Korea

Site Status

Department of Clinical Research Pharmacy, Konkuk University Medical Center

Seoul, , South Korea

Site Status

Department of Radiology

Seoul, , South Korea

Site Status

Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center

Seoul, , South Korea

Site Status

Konkuk University Medical Center

Seoul, , South Korea

Site Status

Clinical Trial Center Pharmacy

Seoul, , South Korea

Site Status

Department of Orthopedic Surgery, Samsung Medical Center

Seoul, , South Korea

Site Status

Clinical Trial Pharmacy

Seoul, , South Korea

Site Status

Department of Radiology

Seoul, , South Korea

Site Status

The Catholic University of Korea Seoul St. Mary's Hospital

Seoul, , South Korea

Site Status

Clinical Research Pharmacy, SMG SNU Boramae Medical Center

Seoul, , South Korea

Site Status

Department of Clinical Research Pharmacy, SMG-SNU Boramae Medical Center

Seoul, , South Korea

Site Status

Department of Radiology

Seoul, , South Korea

Site Status

SMG-SNU Boramae Medical Center

Seoul, , South Korea

Site Status

Department of Radiology

Seoul, , South Korea

Site Status

Ewha Womans University Mokdong Hospital

Seoul, , South Korea

Site Status

Clinical Trial Pharmacy

Yangcheon-gu, Seoul, , South Korea

Site Status

Changhua Christian Hospital Clinical Trial Pharmacy

Changhua, , Taiwan

Site Status

Changhua Christian Hospital

Changhua, , Taiwan

Site Status

Chang Gung Memorial Hospital-Kaohsiung Branch Clinical Trial Pharmacy

Kaohsiung City, , Taiwan

Site Status

Chang Gung Memorial Hospital-Kaohsiung Branch

Kaohsiung City, , Taiwan

Site Status

Chung Shan Medical University Hospital Clinical Trial Pharmacy

Taichung, , Taiwan

Site Status

Chung Shan Medical University Hospital

Taichung, , Taiwan

Site Status

China Medical University Hospital

Taichung, , Taiwan

Site Status

Department of Pharmacy, China Medical University Hospital

Taichung, , Taiwan

Site Status

Regional Communal Institution Chernivtsi Regional Clinical Hospital

Chernivtsi, , Ukraine

Site Status

Communal Non-profit Institution "City Clinical Hospital No.27" of Kharkiv City Council

Kharkiv, , Ukraine

Site Status

Government Institution "L.T. Malaya Therapy National Institute of the NAMS of Ukraine"

Kharkiv, , Ukraine

Site Status

Chair of Internal Medicine #2

Kyiv, , Ukraine

Site Status

Oleksandrivska Clinical Hospital Of Kyiv

Kyiv, , Ukraine

Site Status

Kyiv City Clinical Hospital 3,Rheumatology Department

Kyiv, , Ukraine

Site Status

Clinic of NI "NSC"M.D.Strazhesko Institute of Cardiology" of NAMS of Ukraine,

Kyiv, , Ukraine

Site Status

Polyclinic of Administration of Medical Services and Rehabilitation of State Stock Holding Company

Kyiv, , Ukraine

Site Status

Clinic of SI "Institute of Gerontology named after D.F Chebotarov of NAMS of Ukraine"

Kyiv, , Ukraine

Site Status

Clinic of SI Institute of Gerontology named after D.F Chebotarov of NAMS of Ukraine

Kyiv, , Ukraine

Site Status

National Medical University named after O O Bogomolets,

Kyiv, , Ukraine

Site Status

Polyclinic Of Administration of Medical Services and Rehabilitation of SSHC Artem

Kyiv, , Ukraine

Site Status

Communal Non-profit Institution "City Clinical Hospital #5 of Lviv", Therapeutics Department

Lviv, , Ukraine

Site Status

Communal Institution "Odesa Regional Clinical Hospital"

Odesa, , Ukraine

Site Status

Multi-field Medical Center (University Clinic No.1) of Odesa National Medical University,

Odesa, , Ukraine

Site Status

Communal Institution Ternopil University Hospital

Ternopil, , Ukraine

Site Status

Vinnytsia Regional Clinical Hospital named after M.I. Pyrogov, Rheumatology Department,

Vinnytsia, , Ukraine

Site Status

Communal Non-commercial Enterprise "Vinnytsia City Clinical Hospital No 1"

Vinnytsia, , Ukraine

Site Status

Medical Clinical Investigational Centre of Medical Centre Health Clinic LTD

Vinnytsia, , Ukraine

Site Status

Scientific and Research Institute of Invalid Rehabilitation (Educational and Scientific Medical

Vinnytsia, , Ukraine

Site Status

Vinnytsya Medical National University named after M.I. Pyrogov, Chair of Internal Medicine #3

Vinnytsia, , Ukraine

Site Status

Communal Institution Zaporizhzhya Regional Clinical Hospital

Zaporizhzhya, , Ukraine

Site Status

Countries

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United States Australia Brazil Bulgaria Colombia Croatia Japan Lithuania Mexico New Zealand Peru Philippines Russia Serbia Slovakia South Korea Taiwan Ukraine

References

Explore related publications, articles, or registry entries linked to this study.

Schnitzer TJ, Conaghan PG, Berenbaum F, Abraham L, Cappelleri JC, Bushmakin AG, Viktrup L, Yang R, Brown MT. Effect size varies based on calculation method and may affect interpretation of treatment effect: an illustration using randomised clinical trials in osteoarthritis. Adv Rheumatol. 2024 Apr 22;64(1):31. doi: 10.1186/s42358-024-00358-y.

Reference Type DERIVED
PMID: 38650049 (View on PubMed)

Guermazi A, Roemer FW, Kompel AJ, Diaz LE, Crema MD, Brown MT, Hickman A, Pixton GC, Viktrup L, Fountaine RJ, Burr A, Sherlock SP, West CR. Inter-Reader Consistency and Exclusionary Findings During Radiographic Screening for Phase 3 Trials of Tanezumab in Patients With Osteoarthritis. Osteoarthr Imaging. 2022 Sep-Dec;2(3-4):100082. doi: 10.1016/j.ostima.2022.100082. Epub 2022 Nov 15.

Reference Type DERIVED
PMID: 38343426 (View on PubMed)

Carrino JA, McAlindon TE, Schnitzer TJ, Guermazi A, Hochberg MC, Conaghan PG, Brown MT, Burr A, Fountaine RJ, Pixton GC, Viktrup L, Verburg KM, West CR. Characterization of adverse joint outcomes in patients with osteoarthritis treated with subcutaneous tanezumab. Osteoarthritis Cartilage. 2023 Dec;31(12):1612-1626. doi: 10.1016/j.joca.2023.08.010. Epub 2023 Aug 29.

Reference Type DERIVED
PMID: 37652258 (View on PubMed)

Shoji S, Suzuki A, Nouri P, Cai CH, Gaitonde P, Marshall S. Prediction of relative change in free nerve growth factor following subcutaneous administration of tanezumab, a novel monoclonal antibody to nerve growth factor. CPT Pharmacometrics Syst Pharmacol. 2023 Sep;12(9):1358-1370. doi: 10.1002/psp4.13015. Epub 2023 Jul 31.

Reference Type DERIVED
PMID: 37470295 (View on PubMed)

Hunter DJ, Schnitzer TJ, Hall J, Semel D, Davignon I, Cappelleri JC, Bushmakin AG, Abraham L. Time to first and sustained improvement in WOMAC domains among patients with osteoarthritis receiving tanezumab. Osteoarthr Cartil Open. 2022 Jul 2;4(3):100294. doi: 10.1016/j.ocarto.2022.100294. eCollection 2022 Sep.

Reference Type DERIVED
PMID: 36474952 (View on PubMed)

Atkinson J, Edwards RA, Bonfanti G, Barroso J, Schnitzer TJ. A Two-Step, Trajectory-Focused, Analytics Approach to Attempt Prediction of Analgesic Response in Patients with Moderate-to-Severe Osteoarthritis. Adv Ther. 2023 Jan;40(1):252-264. doi: 10.1007/s12325-022-02336-6. Epub 2022 Oct 27.

Reference Type DERIVED
PMID: 36301512 (View on PubMed)

Mease P, Kuritzky L, Wright WL, Mallick-Searle T, Fountaine R, Yang R, Sadrarhami M, Faison W, Johnston E, Viktrup L. Efficacy and safety of tanezumab, NSAIDs, and placebo in patients with moderate to severe hip or knee osteoarthritis and a history of depression, anxiety, or insomnia: post-hoc analysis of phase 3 trials. Curr Med Res Opin. 2022 Nov;38(11):1909-1922. doi: 10.1080/03007995.2022.2113689. Epub 2022 Aug 28.

Reference Type DERIVED
PMID: 35980115 (View on PubMed)

Schnitzer TJ, Bonfanti G, Atkinson J, Donevan S, Viktrup L, Barroso J, Whalen E, Edwards RA. Characterizing 16-Week Responder Profiles Using Group-Based Trajectory Modeling in Over 4300 Clinical Trial Participants Receiving Pharmaceutical Treatment for Moderate to Severe Osteoarthritis. Adv Ther. 2022 Oct;39(10):4742-4756. doi: 10.1007/s12325-022-02290-3. Epub 2022 Aug 12.

Reference Type DERIVED
PMID: 35960482 (View on PubMed)

Neogi T, Hunter DJ, Churchill M, Shirinsky I, White A, Guermazi A, Omata M, Fountaine RJ, Pixton G, Viktrup L, Brown MT, West CR, Verburg KM. Observed efficacy and clinically important improvements in participants with osteoarthritis treated with subcutaneous tanezumab: results from a 56-week randomized NSAID-controlled study. Arthritis Res Ther. 2022 Mar 29;24(1):78. doi: 10.1186/s13075-022-02759-0.

Reference Type DERIVED
PMID: 35351194 (View on PubMed)

Conaghan PG, Dworkin RH, Schnitzer TJ, Berenbaum F, Bushmakin AG, Cappelleri JC, Viktrup L, Abraham L. WOMAC Meaningful Within-patient Change: Results From 3 Studies of Tanezumab in Patients With Moderate-to-severe Osteoarthritis of the Hip or Knee. J Rheumatol. 2022 Jun;49(6):615-621. doi: 10.3899/jrheum.210543. Epub 2022 Mar 1.

Reference Type DERIVED
PMID: 35232805 (View on PubMed)

Brown MT, Sandroni P, Low PA, Gorson KC, Hunter DJ, Pixton GC, Fountaine RJ, Viktrup L, West CR, Verburg KM. Neurological safety of subcutaneous tanezumab versus NSAID in patients with osteoarthritis. J Neurol Sci. 2022 Mar 15;434:120184. doi: 10.1016/j.jns.2022.120184. Epub 2022 Feb 14.

Reference Type DERIVED
PMID: 35217440 (View on PubMed)

Hochberg MC, Carrino JA, Schnitzer TJ, Guermazi A, Walsh DA, White A, Nakajo S, Fountaine RJ, Hickman A, Pixton G, Viktrup L, Brown MT, West CR, Verburg KM. Long-Term Safety and Efficacy of Subcutaneous Tanezumab Versus Nonsteroidal Antiinflammatory Drugs for Hip or Knee Osteoarthritis: A Randomized Trial. Arthritis Rheumatol. 2021 Jul;73(7):1167-1177. doi: 10.1002/art.41674. Epub 2021 Jun 7.

Reference Type DERIVED
PMID: 33538113 (View on PubMed)

Provided Documents

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Document Type: Statistical Analysis Plan

View Document

Document Type: Study Protocol

View Document

Other Identifiers

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2012-003721-22

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

OA SAFETY STUDY

Identifier Type: OTHER

Identifier Source: secondary_id

A4091058

Identifier Type: -

Identifier Source: org_study_id

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