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Dietary Arachidonic Acid, Obe...

Dietary Arachidonic Acid, Obesity and Atopic Respiratory Disease

Last Updated: 2015-08-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2001-10-31

Study Completion Date

2003-05-31

Brief Summary

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Epidemiological studies have shown obesity to be a risk factor of asthma. Research evidence of obesity and atopic(ie. allergic)-related respiratory diseases, has been less clear. The purpose of the present study was to test the hypothesis that the relationship between obesity and atopic-related respiratory disease in premenopausal women is mediated by a dietary imbalance of omega 6 and 3 polyunsaturated fatty acids.

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Detailed Description

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Sixty young adult obese and non obese women, with, and without asthma, were studied using a cross-sectional design. Body composition was measured by plethysmography. A fasted blood sample was taken to measure: specific and total immunoglobulin (IgE) antibodies,biochemical markers of atopy; glucose and insulin to measure insulin sensitivity; estrogen(17β-estradiol) and sex hormone-binding globulin to measure estrogen status of the women; hormone-products of fat tissue ( leptin, adiponectin, resistin, tumor necrosis factor alpha (TNFα), interleukins (IL-6,IL-18), that have been associated with both obesity and immune processes involved in asthma and allergy. Dietary intake of omega 6: linoleic acid (LA), arachidonic acid(AA); and omega 3 fatty acids: α linolenic (ALA), eicosapentanoic (EPA) and docosahexanoic (DHA) and other nutrients were assessed by food frequency questionnaire.

Conditions

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Allergy Obesity

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* For asthmatics, only individuals that were willing and capable of not using asthma medications for two days prior to laboratory testing.

Exclusion Criteria

* An individual was excluded from the study if she had a history of high blood pressure, diabetes, heart disease, cigarette smoking, or eating disorders.
* Women that were pregnant or lactating.

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Responsible Party

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Anthony R. Tagliaferro

Professor of Human Nutrition

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O'Keefe JH, Brand-Miller J. Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr. 2005 Feb;81(2):341-54. doi: 10.1093/ajcn.81.2.341.

Reference Type RESULT

PMID: 15699220 (View on PubMed)

Linneberg A, Gislum M, Johansen N, Husemoen LL, Jorgensen T. Temporal trends of aeroallergen sensitization over twenty-five years. Clin Exp Allergy. 2007 Aug;37(8):1137-42. doi: 10.1111/j.1365-2222.2007.02760.x.

Reference Type RESULT

PMID: 17651142 (View on PubMed)

Holt PG, Macaubas C, Stumbles PA, Sly PD. The role of allergy in the development of asthma. Nature. 1999 Nov 25;402(6760 Suppl):B12-7. doi: 10.1038/35037009.

Reference Type RESULT

PMID: 10586890 (View on PubMed)

Beuther DA. Recent insight into obesity and asthma. Curr Opin Pulm Med. 2010 Jan;16(1):64-70. doi: 10.1097/MCP.0b013e3283338fa7.

Reference Type RESULT

PMID: 19844182 (View on PubMed)

Ma J, Xiao L, Knowles SB. Obesity, insulin resistance and the prevalence of atopy and asthma in US adults. Allergy. 2010 Nov;65(11):1455-63. doi: 10.1111/j.1398-9995.2010.02402.x.

Reference Type RESULT

PMID: 20456316 (View on PubMed)

Chen Y, Rennie D, Cormier Y, Dosman J. Atopy, obesity, and asthma in adults: the Humboldt study. J Agromedicine. 2009;14(2):222-7. doi: 10.1080/10599240902724051.

Reference Type RESULT

PMID: 19437281 (View on PubMed)

Husemoen LL, Glumer C, Lau C, Pisinger C, Morch LS, Linneberg A. Association of obesity and insulin resistance with asthma and aeroallergen sensitization. Allergy. 2008 May;63(5):575-82. doi: 10.1111/j.1398-9995.2007.01613.x.

Reference Type RESULT

PMID: 18394132 (View on PubMed)

Vieira VJ, Ronan AM, Windt MR, Tagliaferro AR. Elevated atopy in healthy obese women. Am J Clin Nutr. 2005 Sep;82(3):504-9. doi: 10.1093/ajcn.82.3.504.

Reference Type RESULT

PMID: 16155260 (View on PubMed)

Ouyang F, Kumar R, Pongracic J, Story RE, Liu X, Wang B, Xing H, Liu X, Li Z, Zhang W, Fang Y, Zhang S, Xu X, Wang X. Adiposity, serum lipid levels, and allergic sensitization in Chinese men and women. J Allergy Clin Immunol. 2009 Apr;123(4):940-8.e10. doi: 10.1016/j.jaci.2008.11.032. Epub 2009 Jan 9.

Reference Type RESULT

PMID: 19135238 (View on PubMed)

Kay AB. Allergy and allergic diseases. First of two parts. N Engl J Med. 2001 Jan 4;344(1):30-7. doi: 10.1056/NEJM200101043440106. No abstract available.

Reference Type RESULT

PMID: 11136958 (View on PubMed)

Wood JD, Enser M, Richardson RI, Whittington FM. Fatty acids in meat and meat products. 3rd ed. In: Chow CK ed. Fatty acids in food and health complications. Boca Raton, FL: CRC Press, 2008;87-107.

Reference Type RESULT

Wortman P, Miyazaki Y, Kalupahana NS, Kim S, Hansen-Petrik M, Saxton AM, Claycombe KJ, Voy BH, Whelan J, Moustaid-Moussa N. n3 and n6 polyunsaturated fatty acids differentially modulate prostaglandin E secretion but not markers of lipogenesis in adipocytes. Nutr Metab (Lond). 2009 Jan 21;6:5. doi: 10.1186/1743-7075-6-5.

Reference Type RESULT

PMID: 19159447 (View on PubMed)

Decsi T, Molnar D, Koletzko B. Long-chain polyunsaturated fatty acids in plasma lipids of obese children. Lipids. 1996 Mar;31(3):305-11. doi: 10.1007/BF02529877.

Reference Type RESULT

PMID: 8900460 (View on PubMed)

Savva SC, Chadjigeorgiou C, Hatzis C, Kyriakakis M, Tsimbinos G, Tornaritis M, Kafatos A. Association of adipose tissue arachidonic acid content with BMI and overweight status in children from Cyprus and Crete. Br J Nutr. 2004 Apr;91(4):643-9. doi: 10.1079/BJN20031084.

Reference Type RESULT

PMID: 15035692 (View on PubMed)

Massiera F, Saint-Marc P, Seydoux J, Murata T, Kobayashi T, Narumiya S, Guesnet P, Amri EZ, Negrel R, Ailhaud G. Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? J Lipid Res. 2003 Feb;44(2):271-9. doi: 10.1194/jlr.M200346-JLR200. Epub 2002 Nov 4.

Reference Type RESULT

PMID: 12576509 (View on PubMed)

Jaworski K, Ahmadian M, Duncan RE, Sarkadi-Nagy E, Varady KA, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Kim KH, de Val S, Kang C, Sul HS. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nat Med. 2009 Feb;15(2):159-68. doi: 10.1038/nm.1904. Epub 2009 Jan 11.

Reference Type RESULT

PMID: 19136964 (View on PubMed)

Caspar-Bauguil S, Fioroni A, Galinier A, Allenbach S, Pujol MC, Salvayre R, Cartier A, Lemieux I, Richard D, Biron S, Marceau P, Casteilla L, Penicaud L, Mauriege P. Pro-inflammatory phospholipid arachidonic acid/eicosapentaenoic acid ratio of dysmetabolic severely obese women. Obes Surg. 2012 Jun;22(6):935-44. doi: 10.1007/s11695-012-0633-0.

Reference Type RESULT

PMID: 22460550 (View on PubMed)

Fain JN, Madan AK, Hiler ML, Cheema P, Bahouth SW. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology. 2004 May;145(5):2273-82. doi: 10.1210/en.2003-1336. Epub 2004 Jan 15.

Reference Type RESULT

PMID: 14726444 (View on PubMed)

Snijdewint FG, Kalinski P, Wierenga EA, Bos JD, Kapsenberg ML. Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J Immunol. 1993 Jun 15;150(12):5321-9.

Reference Type RESULT

PMID: 8390534 (View on PubMed)

Bao YS, Zhang P, Xie RJ, Wang M, Wang ZY, Zhou Z, Zhai WJ, Feng SZ, Han MZ. The regulation of CD4+ T cell immune responses toward Th2 cell development by prostaglandin E2. Int Immunopharmacol. 2011 Oct;11(10):1599-605. doi: 10.1016/j.intimp.2011.05.021. Epub 2011 May 31.

Reference Type RESULT

PMID: 21635971 (View on PubMed)

Hersoug LG, Linneberg A. The link between the epidemics of obesity and allergic diseases: does obesity induce decreased immune tolerance? Allergy. 2007 Oct;62(10):1205-13. doi: 10.1111/j.1398-9995.2007.01506.x.

Reference Type RESULT

PMID: 17845592 (View on PubMed)

Couet C, Delarue J, Ritz P, Antoine JM, Lamisse F. Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults. Int J Obes Relat Metab Disord. 1997 Aug;21(8):637-43. doi: 10.1038/sj.ijo.0800451.

Reference Type RESULT

PMID: 15481762 (View on PubMed)

Calder PC. The relationship between the fatty acid composition of immune cells and their function. Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov;79(3-5):101-8. doi: 10.1016/j.plefa.2008.09.016. Epub 2008 Oct 23.

Reference Type RESULT

PMID: 18951005 (View on PubMed)

Williams PB, Barnes JH, Szeinbach SL, Sullivan TJ. Analytic precision and accuracy of commercial immunoassays for specific IgE: establishing a standard. J Allergy Clin Immunol. 2000 Jun;105(6 Pt 1):1221-30. doi: 10.1067/mai.2000.105219.

Reference Type RESULT

PMID: 10856158 (View on PubMed)

Chen W, Mempel M, Schober W, Behrendt H, Ring J. Gender difference, sex hormones, and immediate type hypersensitivity reactions. Allergy. 2008 Nov;63(11):1418-27. doi: 10.1111/j.1398-9995.2008.01880.x.

Reference Type RESULT

PMID: 18925878 (View on PubMed)

Duncan MH, Singh BM, Wise PH, Carter G, Alaghband-Zadeh J. A simple measure of insulin resistance. Lancet. 1995 Jul 8;346(8967):120-1. doi: 10.1016/s0140-6736(95)92143-5. No abstract available.

Reference Type RESULT

PMID: 7603193 (View on PubMed)

Liu S, Manson JE, Stampfer MJ, Holmes MD, Hu FB, Hankinson SE, Willett WC. Dietary glycemic load assessed by food-frequency questionnaire in relation to plasma high-density-lipoprotein cholesterol and fasting plasma triacylglycerols in postmenopausal women. Am J Clin Nutr. 2001 Mar;73(3):560-6. doi: 10.1093/ajcn/73.3.560.

Reference Type RESULT

PMID: 11237932 (View on PubMed)

Black PN, Sharpe S. Dietary fat and asthma: is there a connection? Eur Respir J. 1997 Jan;10(1):6-12. doi: 10.1183/09031936.97.10010006.

Reference Type RESULT

PMID: 9032484 (View on PubMed)

Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002 Oct;56(8):365-79. doi: 10.1016/s0753-3322(02)00253-6.

Reference Type RESULT

PMID: 12442909 (View on PubMed)

Daniel CR, Cross AJ, Koebnick C, Sinha R. Trends in meat consumption in the USA. Public Health Nutr. 2011 Apr;14(4):575-83. doi: 10.1017/S1368980010002077. Epub 2010 Nov 12.

Reference Type RESULT

PMID: 21070685 (View on PubMed)

Rule DC, Broughton KS, Shellito SM, Maiorano G. Comparison of muscle fatty acid profiles and cholesterol concentrations of bison, beef cattle, elk, and chicken. J Anim Sci. 2002 May;80(5):1202-11. doi: 10.2527/2002.8051202x.

Reference Type RESULT

PMID: 12019607 (View on PubMed)

Clifton PM, Condo D, Keogh JB. Long term weight maintenance after advice to consume low carbohydrate, higher protein diets--a systematic review and meta analysis. Nutr Metab Cardiovasc Dis. 2014 Mar;24(3):224-35. doi: 10.1016/j.numecd.2013.11.006. Epub 2013 Dec 20.

Reference Type RESULT

PMID: 24472635 (View on PubMed)

Melanson K, Gootman J, Myrdal A, Kline G, Rippe JM. Weight loss and total lipid profile changes in overweight women consuming beef or chicken as the primary protein source. Nutrition. 2003 May;19(5):409-14. doi: 10.1016/s0899-9007(02)01080-8.

Reference Type RESULT

PMID: 12714091 (View on PubMed)

Moreau D, Kalaboka S, Choquet M, Annesi-Maesano I. Asthma, obesity, and eating behaviors according to the diagnostic and statistical manual of mental disorders IV in a large population-based sample of adolescents. Am J Clin Nutr. 2009 May;89(5):1292-8. doi: 10.3945/ajcn.2008.26954. Epub 2009 Mar 25.

Reference Type RESULT

PMID: 19321566 (View on PubMed)

Miles EA, Aston L, Calder PC. In vitro effects of eicosanoids derived from different 20-carbon fatty acids on T helper type 1 and T helper type 2 cytokine production in human whole-blood cultures. Clin Exp Allergy. 2003 May;33(5):624-32. doi: 10.1046/j.1365-2222.2003.01637.x.

Reference Type RESULT

PMID: 12752591 (View on PubMed)

Roper RL, Brown DM, Phipps RP. Prostaglandin E2 promotes B lymphocyte Ig isotype switching to IgE. J Immunol. 1995 Jan 1;154(1):162-70.

Reference Type RESULT

PMID: 7995935 (View on PubMed)

Nagel G, Nieters A, Becker N, Linseisen J. The influence of the dietary intake of fatty acids and antioxidants on hay fever in adults. Allergy. 2003 Dec;58(12):1277-84. doi: 10.1046/j.1398-9995.2003.00296.x.

Reference Type RESULT

PMID: 14616103 (View on PubMed)

Kompauer I, Demmelmair H, Koletzko B, Bolte G, Linseisen J, Heinrich J. Association of fatty acids in serum phospholipids with hay fever, specific and total immunoglobulin E. Br J Nutr. 2005 Apr;93(4):529-35. doi: 10.1079/bjn20041387.

Reference Type RESULT

PMID: 15946416 (View on PubMed)

Krebs JD, Browning LM, McLean NK, Rothwell JL, Mishra GD, Moore CS, Jebb SA. Additive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic women. Int J Obes (Lond). 2006 Oct;30(10):1535-44. doi: 10.1038/sj.ijo.0803309. Epub 2006 Mar 21.

Reference Type RESULT

PMID: 16552404 (View on PubMed)

Tsang JY, Li D, Ho D, Peng J, Xu A, Lamb J, Chen Y, Tam PK. Novel immunomodulatory effects of adiponectin on dendritic cell functions. Int Immunopharmacol. 2011 May;11(5):604-9. doi: 10.1016/j.intimp.2010.11.009. Epub 2010 Nov 19.

Reference Type RESULT

PMID: 21094289 (View on PubMed)

De Rosa V, Procaccini C, Cali G, Pirozzi G, Fontana S, Zappacosta S, La Cava A, Matarese G. A key role of leptin in the control of regulatory T cell proliferation. Immunity. 2007 Feb;26(2):241-55. doi: 10.1016/j.immuni.2007.01.011.

Reference Type RESULT

PMID: 17307705 (View on PubMed)

Lloyd CM, Hawrylowicz CM. Regulatory T cells in asthma. Immunity. 2009 Sep 18;31(3):438-49. doi: 10.1016/j.immuni.2009.08.007.

Reference Type RESULT

PMID: 19766086 (View on PubMed)

Manigrasso MR, Ferroni P, Santilli F, Taraborelli T, Guagnano MT, Michetti N, Davi G. Association between circulating adiponectin and interleukin-10 levels in android obesity: effects of weight loss. J Clin Endocrinol Metab. 2005 Oct;90(10):5876-9. doi: 10.1210/jc.2005-0281. Epub 2005 Jul 19.

Reference Type RESULT

PMID: 16030165 (View on PubMed)

Nagel G, Koenig W, Rapp K, Wabitsch M, Zoellner I, Weiland SK. Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. Pediatr Allergy Immunol. 2009 Feb;20(1):81-8. doi: 10.1111/j.1399-3038.2008.00740.x. Epub 2008 Mar 7.

Reference Type RESULT

PMID: 18331416 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

UNH-01-2536-01

Identifier Type: -

Identifier Source: org_study_id

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Dietary Arachidonic Acid, Obesity and Atopic Respiratory Disease

Study Results

Basic Information

Brief Summary

Related Clinical Trials

Obesity and Asthma: Nutrigenetic Response to Omega-3 Fatty Acids

Fish Oil and Asthma in House Dust Mite Allergy

A Phase II Randomized Trial of Fish Oil in Patients With Acute Lung Injury (ALI)

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High Omega-3/Low Omega-6 Treatment Diet for Aspirin-exacerbated Respiratory Disease (AERD)

Detailed Description

Conditions

Study Design

Eligibility Criteria

Inclusion Criteria

Exclusion Criteria

Sponsors

University of New Hampshire

Responsible Party

Anthony R. Tagliaferro

References

Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O'Keefe JH, Brand-Miller J. Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr. 2005 Feb;81(2):341-54. doi: 10.1093/ajcn.81.2.341.

Linneberg A, Gislum M, Johansen N, Husemoen LL, Jorgensen T. Temporal trends of aeroallergen sensitization over twenty-five years. Clin Exp Allergy. 2007 Aug;37(8):1137-42. doi: 10.1111/j.1365-2222.2007.02760.x.

Holt PG, Macaubas C, Stumbles PA, Sly PD. The role of allergy in the development of asthma. Nature. 1999 Nov 25;402(6760 Suppl):B12-7. doi: 10.1038/35037009.

Beuther DA. Recent insight into obesity and asthma. Curr Opin Pulm Med. 2010 Jan;16(1):64-70. doi: 10.1097/MCP.0b013e3283338fa7.

Ma J, Xiao L, Knowles SB. Obesity, insulin resistance and the prevalence of atopy and asthma in US adults. Allergy. 2010 Nov;65(11):1455-63. doi: 10.1111/j.1398-9995.2010.02402.x.

Chen Y, Rennie D, Cormier Y, Dosman J. Atopy, obesity, and asthma in adults: the Humboldt study. J Agromedicine. 2009;14(2):222-7. doi: 10.1080/10599240902724051.

Husemoen LL, Glumer C, Lau C, Pisinger C, Morch LS, Linneberg A. Association of obesity and insulin resistance with asthma and aeroallergen sensitization. Allergy. 2008 May;63(5):575-82. doi: 10.1111/j.1398-9995.2007.01613.x.

Vieira VJ, Ronan AM, Windt MR, Tagliaferro AR. Elevated atopy in healthy obese women. Am J Clin Nutr. 2005 Sep;82(3):504-9. doi: 10.1093/ajcn.82.3.504.

Kay AB. Allergy and allergic diseases. First of two parts. N Engl J Med. 2001 Jan 4;344(1):30-7. doi: 10.1056/NEJM200101043440106. No abstract available.

Wood JD, Enser M, Richardson RI, Whittington FM. Fatty acids in meat and meat products. 3rd ed. In: Chow CK ed. Fatty acids in food and health complications. Boca Raton, FL: CRC Press, 2008;87-107.

Decsi T, Molnar D, Koletzko B. Long-chain polyunsaturated fatty acids in plasma lipids of obese children. Lipids. 1996 Mar;31(3):305-11. doi: 10.1007/BF02529877.

Savva SC, Chadjigeorgiou C, Hatzis C, Kyriakakis M, Tsimbinos G, Tornaritis M, Kafatos A. Association of adipose tissue arachidonic acid content with BMI and overweight status in children from Cyprus and Crete. Br J Nutr. 2004 Apr;91(4):643-9. doi: 10.1079/BJN20031084.

Snijdewint FG, Kalinski P, Wierenga EA, Bos JD, Kapsenberg ML. Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J Immunol. 1993 Jun 15;150(12):5321-9.

Bao YS, Zhang P, Xie RJ, Wang M, Wang ZY, Zhou Z, Zhai WJ, Feng SZ, Han MZ. The regulation of CD4+ T cell immune responses toward Th2 cell development by prostaglandin E2. Int Immunopharmacol. 2011 Oct;11(10):1599-605. doi: 10.1016/j.intimp.2011.05.021. Epub 2011 May 31.

Hersoug LG, Linneberg A. The link between the epidemics of obesity and allergic diseases: does obesity induce decreased immune tolerance? Allergy. 2007 Oct;62(10):1205-13. doi: 10.1111/j.1398-9995.2007.01506.x.

Couet C, Delarue J, Ritz P, Antoine JM, Lamisse F. Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults. Int J Obes Relat Metab Disord. 1997 Aug;21(8):637-43. doi: 10.1038/sj.ijo.0800451.

Calder PC. The relationship between the fatty acid composition of immune cells and their function. Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov;79(3-5):101-8. doi: 10.1016/j.plefa.2008.09.016. Epub 2008 Oct 23.

Williams PB, Barnes JH, Szeinbach SL, Sullivan TJ. Analytic precision and accuracy of commercial immunoassays for specific IgE: establishing a standard. J Allergy Clin Immunol. 2000 Jun;105(6 Pt 1):1221-30. doi: 10.1067/mai.2000.105219.

Chen W, Mempel M, Schober W, Behrendt H, Ring J. Gender difference, sex hormones, and immediate type hypersensitivity reactions. Allergy. 2008 Nov;63(11):1418-27. doi: 10.1111/j.1398-9995.2008.01880.x.

Duncan MH, Singh BM, Wise PH, Carter G, Alaghband-Zadeh J. A simple measure of insulin resistance. Lancet. 1995 Jul 8;346(8967):120-1. doi: 10.1016/s0140-6736(95)92143-5. No abstract available.

Black PN, Sharpe S. Dietary fat and asthma: is there a connection? Eur Respir J. 1997 Jan;10(1):6-12. doi: 10.1183/09031936.97.10010006.

Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002 Oct;56(8):365-79. doi: 10.1016/s0753-3322(02)00253-6.

Daniel CR, Cross AJ, Koebnick C, Sinha R. Trends in meat consumption in the USA. Public Health Nutr. 2011 Apr;14(4):575-83. doi: 10.1017/S1368980010002077. Epub 2010 Nov 12.

Rule DC, Broughton KS, Shellito SM, Maiorano G. Comparison of muscle fatty acid profiles and cholesterol concentrations of bison, beef cattle, elk, and chicken. J Anim Sci. 2002 May;80(5):1202-11. doi: 10.2527/2002.8051202x.

Clifton PM, Condo D, Keogh JB. Long term weight maintenance after advice to consume low carbohydrate, higher protein diets--a systematic review and meta analysis. Nutr Metab Cardiovasc Dis. 2014 Mar;24(3):224-35. doi: 10.1016/j.numecd.2013.11.006. Epub 2013 Dec 20.

Melanson K, Gootman J, Myrdal A, Kline G, Rippe JM. Weight loss and total lipid profile changes in overweight women consuming beef or chicken as the primary protein source. Nutrition. 2003 May;19(5):409-14. doi: 10.1016/s0899-9007(02)01080-8.

Miles EA, Aston L, Calder PC. In vitro effects of eicosanoids derived from different 20-carbon fatty acids on T helper type 1 and T helper type 2 cytokine production in human whole-blood cultures. Clin Exp Allergy. 2003 May;33(5):624-32. doi: 10.1046/j.1365-2222.2003.01637.x.

Roper RL, Brown DM, Phipps RP. Prostaglandin E2 promotes B lymphocyte Ig isotype switching to IgE. J Immunol. 1995 Jan 1;154(1):162-70.

Nagel G, Nieters A, Becker N, Linseisen J. The influence of the dietary intake of fatty acids and antioxidants on hay fever in adults. Allergy. 2003 Dec;58(12):1277-84. doi: 10.1046/j.1398-9995.2003.00296.x.

Kompauer I, Demmelmair H, Koletzko B, Bolte G, Linseisen J, Heinrich J. Association of fatty acids in serum phospholipids with hay fever, specific and total immunoglobulin E. Br J Nutr. 2005 Apr;93(4):529-35. doi: 10.1079/bjn20041387.

Tsang JY, Li D, Ho D, Peng J, Xu A, Lamb J, Chen Y, Tam PK. Novel immunomodulatory effects of adiponectin on dendritic cell functions. Int Immunopharmacol. 2011 May;11(5):604-9. doi: 10.1016/j.intimp.2010.11.009. Epub 2010 Nov 19.

De Rosa V, Procaccini C, Cali G, Pirozzi G, Fontana S, Zappacosta S, La Cava A, Matarese G. A key role of leptin in the control of regulatory T cell proliferation. Immunity. 2007 Feb;26(2):241-55. doi: 10.1016/j.immuni.2007.01.011.

Lloyd CM, Hawrylowicz CM. Regulatory T cells in asthma. Immunity. 2009 Sep 18;31(3):438-49. doi: 10.1016/j.immuni.2009.08.007.

Manigrasso MR, Ferroni P, Santilli F, Taraborelli T, Guagnano MT, Michetti N, Davi G. Association between circulating adiponectin and interleukin-10 levels in android obesity: effects of weight loss. J Clin Endocrinol Metab. 2005 Oct;90(10):5876-9. doi: 10.1210/jc.2005-0281. Epub 2005 Jul 19.

Nagel G, Koenig W, Rapp K, Wabitsch M, Zoellner I, Weiland SK. Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. Pediatr Allergy Immunol. 2009 Feb;20(1):81-8. doi: 10.1111/j.1399-3038.2008.00740.x. Epub 2008 Mar 7.

Other Identifiers

UNH-01-2536-01

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