Diabetes Risk Reduction Through Eat, Walk, Sleep and Medication Therapy Management for Depressed Cambodians

NCT ID: NCT02502929

Last Updated: 2021-02-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

182 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-11-30

Study Completion Date

2020-09-30

Brief Summary

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The primary aim of the study is to compare the effect of three different interventions on lifestyle risk factors and biological risk factors for type 2 diabetes in depressed Cambodians. The three different interventions are lifestyle, lifestyle plus medication therapy management, and social services.

Detailed Description

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Cambodian Americans have high risk for major depressive disorder and for type 2 diabetes. Depression is a known risk factor for diabetes. Some antidepressants can also increase risk of diabetes by causing weight gain. DREAM will test the effect of lifestyle and medication therapy management (MTM) compared to social services (control) on diabetes risk among depressed Cambodian Americans. Community health workers (CHWs) will deliver the lifestyle intervention and assist pharmacists with MTM. Lifestyle and biological risk factors for diabetes, such as depressive symptoms, HbA1c and insulin sensitivity, will be measured before and after the interventions.

Conditions

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Diabetes Depression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Social Services

Participants in this arm will receive referrals for social services as indicated.

Group Type ACTIVE_COMPARATOR

Social Services

Intervention Type BEHAVIORAL

Lifestyle

Participants in this arm will receive lifestyle modification from community health workers using the manualized lifestyle intervention called "Eat, Walk, Sleep". They will receive individual home visits, health activity group sessions, and supportive phone calls.

Group Type EXPERIMENTAL

Lifestyle

Intervention Type BEHAVIORAL

Lifestyle plus Medication Therapy Management

Participants in this arm will receive everything in the Lifestyle arm, plus Medication Therapy Management (MTM). Participants will receive MTM from a pharmacist via telemedicine with the assistance of a community health worker.

Group Type EXPERIMENTAL

Lifestyle Plus Medication Therapy Management

Intervention Type BEHAVIORAL

Interventions

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Social Services

Intervention Type BEHAVIORAL

Lifestyle

Intervention Type BEHAVIORAL

Lifestyle Plus Medication Therapy Management

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Self-identified as Cambodian or Cambodian-American
* Khmer speaking
* Likely major depressive disorder
* Elevated diabetes risk score per ADA guidelines
* Ambulatory
* Competent to give consent.

Exclusion Criteria

* Pregnancy or plans to become pregnant in the next 2 years
* Previous diagnosis of diabetes
* Seeing or hearing problems that would interfere with group sessions
* Currently being followed by a physician for major medical problem
* Serious thinking or memory problems (e.g., schizophrenia or dementia)
* 3 or more days in a psychiatric hospital or self-harm in the past 2 years.
Minimum Eligible Age

35 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Khmer Health Advocates

UNKNOWN

Sponsor Role collaborator

Penn State University

OTHER

Sponsor Role collaborator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

Sponsor Role collaborator

UConn Health

OTHER

Sponsor Role lead

Responsible Party

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Julie A. Wagner

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Julie A Wagner, PhD

Role: PRINCIPAL_INVESTIGATOR

UConn Health

Locations

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Uconn Health

Farmington, Connecticut, United States

Site Status

Khmer Health Advocates

West Hartford, Connecticut, United States

Site Status

Center for Southeast Asians

Providence, Rhode Island, United States

Site Status

Countries

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United States

References

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Wagner JA, Bermudez-Millan A, Buckley TE, Buxton OM, Feinn RS, Kong S, Kuoch T, Master L, Scully MF. Secondary analysis of a randomized trial testing community health educator interventions for diabetes prevention among refugees with depression: effects on nutrition, physical activity and sleep. Int J Behav Nutr Phys Act. 2023 Sep 12;20(1):107. doi: 10.1186/s12966-023-01509-y.

Reference Type DERIVED
PMID: 37700288 (View on PubMed)

Wagner J, Bermudez-Millan A, Buckley T, Buxton OM, Feinn R, Kong S, Kuoch T, Nye LM, Scully M. Self-reported outcomes of a randomized trial comparing three community health worker interventions for diabetes prevention among Cambodian Americans with depression. Patient Educ Couns. 2022 Dec;105(12):3501-3508. doi: 10.1016/j.pec.2022.09.011. Epub 2022 Oct 6.

Reference Type DERIVED
PMID: 36307274 (View on PubMed)

Wagner JA, Bermudez-Millan A, Berthold SM, Buckley T, Buxton OM, Feinn R, Kuoch T, Kong S, Lim M, Polomoff C, Scully M. Risk factors for drug therapy problems among Cambodian Americans with complex needs: a cross-sectional, observational study. Health Psychol Behav Med. 2022 Jan 24;10(1):145-159. doi: 10.1080/21642850.2021.2021917. eCollection 2022.

Reference Type DERIVED
PMID: 35087696 (View on PubMed)

Wagner J, Bermudez-Millan A, Buckley T, Buxton OM, Feinn R, Kong S, Kuoch T, Nahmod NG, Scully M. A randomized trial to decrease risk for diabetes among Cambodian Americans with depression: Intervention development, baseline characteristics and process outcomes. Contemp Clin Trials. 2021 Jul;106:106427. doi: 10.1016/j.cct.2021.106427. Epub 2021 May 3.

Reference Type DERIVED
PMID: 33957272 (View on PubMed)

Other Identifiers

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5R01DK103663

Identifier Type: NIH

Identifier Source: secondary_id

View Link

15-164S-3

Identifier Type: -

Identifier Source: org_study_id

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