Influence of Diabetes on Lower Limb Amputation

NCT ID: NCT02500303

Last Updated: 2018-01-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

171 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-03-31

Study Completion Date

2018-12-31

Brief Summary

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The purpose of this study is to explore the factors that influence limb fitting in those with diabetes compared to those without diabetes. The population without diabetes will usually present with peripheral arterial disease (PAD) and are similar in management following LEA. The impact that not walking with a prosthesis has long term on both populations will be explored. In general, previous research has used retrospective analysis of case notes which, although valuable, have fixed fields and only allow the researcher to look at associations between factors not at causation. Additionally, very few have followed a population over time. Therefore this study will be a prospective observational analysis of all those who undergo a LEA in one year from 01/03/14 to 28/02/15 within the Greater Glasgow \& Clyde area with follow up at 6, 12 \& 18 months from date of amputation.

Detailed Description

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This research has been designed to ask the following question: What are the factors that influence the rehabilitation and functional outcomes following LEA, in the long term in both those with and without diabetes.

Therefore this study will be a prospective observational analysis of all those who undergo a LEA in one year within the Greater Glasgow \& Clyde area with follow up at 6, 12 \& 18 months from date of amputation.

* Primary Endpoint Comparison of rehabilitation and functional outcomes in those with diabetes to those without diabetes, up to 18 months post LEA.
* Secondary endpoints

1. At discharge from rehabilitation, the characteristics of those who proceed to limb fitting following LEA to those who do not will be defined.
2. At discharge from rehabilitation, the characteristics of those with diabetes that do not proceed to limb fitting following LEA compared to those who do.
3. At discharge from rehabilitation to 18 months post LEA, a comparison of the characteristics in those with and without diabetes.
4. From six months post LEA, at 6 monthly intervals (6,12 \& 18 months), a comparison of the health status, social circumstances, mobility and quality of life measures in those with and without diabetes.

Conditions

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Diabetes PAD

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Over 18 years of age with a major amputation above the ankle.

Exclusion Criteria

* Amputation for tumour, trauma, congenital abnormalities
* Amputation at hip disarticulation or trans-pelvectomy level
* Adults with incapacity
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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NHS Greater Glasgow and Clyde Board HQ

OTHER

Sponsor Role collaborator

University of Glasgow

OTHER

Sponsor Role lead

Responsible Party

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Fiona Smith

PhD Student & Chief Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Lorna Paul, PhD

Role: STUDY_DIRECTOR

University of Glasgow

Locations

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Western Infirmary

Glasgow, , United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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GN13DI563

Identifier Type: -

Identifier Source: org_study_id

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