Interval Training in Bipolar Disorder

NCT ID: NCT02498730

Last Updated: 2022-07-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-08-31

Study Completion Date

2017-07-31

Brief Summary

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Our main objective will be to evaluate the chronic effects (12 weeks) of high-intensity interval training compared to moderate intensity (same total work) on reducing the symptoms of bipolar disorder, cortical changes, as well as on the VO2max. In addition, the investigators will establish what influence of gain to VO2max has on reducing symptoms.

Detailed Description

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Physical exercise has significant effects on health promotion and the consequent reduction of the severity of bipolar disorder (BD). This review establishes a pattern of response of exercise and potential impact on the pathophysiology of BD; , as well as, produces hypotheses on how acute and chronic effect of exercises may act differently; and provides future perspectives with the focus of the exercise as an important and innovative model of treatment for BD and mental disorder. A critical evaluation of the literature was undertaken including the influence of exercise on health promotion in patients with mental disorders, neurochemical behavior exercise-induced, as well as reflective introduction of news perspectives of training control in severe exercise domain. The exercise induces significant changes in monoaminergic after, and with long-term training, and work with a threshold of exercise can modulate positive effects on mood. Fast adaptive effects from the high intensity interval training should be considered in BD patients. However, there must be caution in his administration. We speculate that exercise may be a way of maintaining euthymia in the case of BD, making it less vulnerable patient to stay longer at a time of neutrality. Future research is needed to adopt a training strategy that is both time efficient in the different areas and adequate for the population in question.

Conditions

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Bipolar Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized Controlled Trial
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Interval Training

6 stimulous (30 s) at 100% VO2Max/ 1 min 30 s to rest, 19 minutes (total exercise), 3 times/ week, 12 weeks

Group Type ACTIVE_COMPARATOR

Interval Training

Intervention Type BEHAVIORAL

High Intensity Interval Training at 100% VO2Max

Continuous Training

Intervention Type BEHAVIORAL

Continuous Stimulous at 60% VO2Max

Continuous Training

Running at 60% VO2Max, 25 minutes (total exercise), 3 times/week, 12 weeks

Group Type ACTIVE_COMPARATOR

Interval Training

Intervention Type BEHAVIORAL

High Intensity Interval Training at 100% VO2Max

Continuous Training

Intervention Type BEHAVIORAL

Continuous Stimulous at 60% VO2Max

Control

Only Dependent Variables Measures

Group Type SHAM_COMPARATOR

Control

Intervention Type BEHAVIORAL

Only Dependent Variables Measures

Interventions

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Interval Training

High Intensity Interval Training at 100% VO2Max

Intervention Type BEHAVIORAL

Continuous Training

Continuous Stimulous at 60% VO2Max

Intervention Type BEHAVIORAL

Control

Only Dependent Variables Measures

Intervention Type BEHAVIORAL

Other Intervention Names

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High intensity interval training HIIT HIT Moderate Training Endurance No Intervention

Eligibility Criteria

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Inclusion Criteria

* Bipolar Criteria (DSM-IV),
* sedentary lifestyle

Exclusion Criteria

* 60 and over,
* Cardiovascular Disease,
* Panic disorder,
* Metabolic syndrome Diagnosis
Minimum Eligible Age

18 Years

Maximum Eligible Age

59 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Universidade Federal do Rio de Janeiro

OTHER

Sponsor Role lead

Responsible Party

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Alberto Souza de Sá Filho

Doctorade in Mental Health

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sérgio E. Machado, PhD

Role: STUDY_DIRECTOR

Universidade Federal do Rio de Janeiro

Locations

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Institute of Psychiatry (IPUB)

Rio de Janeiro, , Brazil

Site Status

Countries

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Brazil

Other Identifiers

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UFRJ-01

Identifier Type: -

Identifier Source: org_study_id

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