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A Study of Aerobic Exercise for Patients With Bipolar Disorder

NCT ID: NCT03353337

Last Updated: 2017-11-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

210 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-12-01

Study Completion Date

2019-12-31

Brief Summary

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This study will investigate the effects of aerobic exercise on mental states, cognition, BDNF, and long-term outcomes in patients with bipolar disorder.

Detailed Description

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Multiple cognitive impairments are common in patients with bipolar disorder. Preliminary evidence shows that aerobic exercise might have positive effects in enhancing cognition and improving clinical symptoms in patients with mood disorders. This randomized controlled trial will investigate short-term (1 months) effects of aerobic exercise on cognition and clinical symptoms as well as the long-term (12 months) effects on decreasing the recurrence rate.

Conditions

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Bipolar Disorder Cognitive Symptom

Keywords

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neurocognition prognosis aerobic exercise

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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aerobic exercise

Cycling at the intensity of 50%-70% of maximum heart rate (220-age) for 30 mins per day, 4 days per week, last for 1 month.

Group Type EXPERIMENTAL

aerobic exercise

Intervention Type BEHAVIORAL

Cycling at the intensity of 50%-70% of maximum heart rate (220-age) for 30 mins per day, 4 days per week, last for 1 months.

Placebo controlled group

General intensity activities of recreation therapy, including Handicraft manufacture, reading activity, singing entertainment, walking.

Group Type PLACEBO_COMPARATOR

Placebo controlled group

Intervention Type BEHAVIORAL

General intensity activities of recreation therapy, including Handicraft manufacture, reading activity, singing entertainment, walking.

Interventions

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aerobic exercise

Cycling at the intensity of 50%-70% of maximum heart rate (220-age) for 30 mins per day, 4 days per week, last for 1 months.

Intervention Type BEHAVIORAL

Placebo controlled group

General intensity activities of recreation therapy, including Handicraft manufacture, reading activity, singing entertainment, walking.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* DSM-IV defined bipolar disorder.
* Never accept aerobic exercise therapy.
* dextromanuality.

Exclusion Criteria

* Diagnosed neurological or musculoskeletal disorder/injury,
* Uncontrolled cardiovascular or metabolic diseases that are not suitable for running
* Diagnosed hypertension
* Other diagnosed serious medical conditions that are not suitable for cycling
* Severe suicidal ideation
* Mental retardation
* Currently participating in a exercise program or activity, defined as 30 minutes of vigorous physical activity 4-5 times per week
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Guangzhou Psychiatric Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Kangguang Lin

MD,PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kangguang Lin, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Guangzhou Brain hospital (Guangzhou Psychiatric Hospital)

Locations

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Guangzhou Brain hospital(Guangzhou Huiai Hospital)

Guangzhou, Guangdong, China

Site Status

Countries

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China

Central Contacts

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Kangguang Lin, MD, PhD

Role: CONTACT

Phone: 13560360144

Email: [email protected]

Yaoguang Guo, MPH

Role: CONTACT

Phone: 13580339565

Email: [email protected]

Facility Contacts

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Kangguang Lin, D.D;Ph.D

Role: primary

Other Identifiers

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GZ Psychiatric Hospital

Identifier Type: -

Identifier Source: org_study_id