HeartMate 3 ELEVATE™ Registry

NCT ID: NCT02497950

Last Updated: 2025-03-20

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

540 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-10-13

Study Completion Date

2022-02-28

Brief Summary

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Evaluate real-world experience of HeartMate 3 (HM3) in post-approval setting.

Detailed Description

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The purpose of this post-market registry is to collect data and evaluate the real-world experience of the HeartMate 3 Left Ventricular Assist System (HM3 LVAS) in a post-approval setting.

Conditions

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Heart Failure Cardiovascular Disease Ventricular Dysfunction

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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HeartMate 3

This registry will include all patients that receive the HM3 LVAS in the post-market setting

HeartMate 3

Intervention Type DEVICE

Any patient that is determined to meet the HM3 commercially approved labelling indication and that is implanted with the HM3

Interventions

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HeartMate 3

Any patient that is determined to meet the HM3 commercially approved labelling indication and that is implanted with the HM3

Intervention Type DEVICE

Other Intervention Names

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HM3

Eligibility Criteria

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Inclusion Criteria

1. Patient consented to registry data collection
2. Patient has met the HeartMate 3 commercially approved labeling indication and is implanted with the HM3.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Thoratec Europe Ltd

INDUSTRY

Sponsor Role collaborator

Thoratec Corporation

INDUSTRY

Sponsor Role collaborator

Abbott Medical Devices

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Finn Gustafsson, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Rigshospitalet, Denmark

Jens Garbade, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Gesundheit Nord Klinikverbund Bremen

Locations

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AJH - Wien

Vienna, , Austria

Site Status

Institute for Clinical and Experimental Medicine (IKEM)

Prague, , Czechia

Site Status

Rigshospitalet Copenhagen

Copenhagen, , Denmark

Site Status

Universitatsklinikum Aachen

Aachen, , Germany

Site Status

Herz- und Gefäßklinik Bad Neustadt a d Saale

Bad Neustadt an der Saale, , Germany

Site Status

Herz-und Diabetes Zentrum NRW

Bad Oeynhausen, , Germany

Site Status

Deutsches Herzzentrum Berlin

Berlin, , Germany

Site Status

Medizinische Einrichtungen der Universitat Dusseldorf

Düsseldorf, , Germany

Site Status

Universitäts-Herzzentrum Freiburg

Freiberg, , Germany

Site Status

Medizinische Hochschule Hannover

Hanover, , Germany

Site Status

Universitätsklinikum Jena

Jena, , Germany

Site Status

Herzentrum Leipzig GmbH

Leipzig, , Germany

Site Status

Universitätsklinikum Schleswig Holstein

Lübeck, , Germany

Site Status

Otto-von-Guericke-Universitat Magdeburg

Magdeburg, , Germany

Site Status

Universitätsklinikum Tübingen

Tübingen, , Germany

Site Status

Sheba Medical Center

Tel Aviv, , Israel

Site Status

Ospedale San Raffaele

Milan, , Italy

Site Status

Az. Osp. San Camillo Forlanini

Roma, , Italy

Site Status

Ospedale Civile Maggiore di Verona Borgo Trento

Verona, , Italy

Site Status

National Research Center for Cardiac Surgery

Astana, , Kazakhstan

Site Status

Erasmus MC - Thoraxcenter

Rotterdam, , Netherlands

Site Status

UMC Utrecht

Utrecht, , Netherlands

Site Status

Warsaw Institute of Cardiology

Warsaw, , Poland

Site Status

National Heart Centre Singapore

Singapore, , Singapore

Site Status

Queen Elizabeth Hospital

Birmingham, , United Kingdom

Site Status

Wythenshawe Hospital

Manchester, , United Kingdom

Site Status

Countries

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Austria Czechia Denmark Germany Israel Italy Kazakhstan Netherlands Poland Singapore United Kingdom

References

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Zimpfer D, Gustafsson F, Potapov E, Pya Y, Schmitto J, Berchtold-Herz M, Morshuis M, Shaw SM, Saeed D, Lavee J, Heatley G, Gazzola C, Garbade J. Two-year outcome after implantation of a full magnetically levitated left ventricular assist device: results from the ELEVATE Registry. Eur Heart J. 2020 Oct 14;41(39):3801-3809. doi: 10.1093/eurheartj/ehaa639.

Reference Type DERIVED
PMID: 33107561 (View on PubMed)

Garbade J, Gustafsson F, Shaw S, Lavee J, Saeed D, Pya Y, Krabatsch T, Schmitto JD, Morshuis M, Chuang J, Zimpfer D. Postmarket Experience With HeartMate 3 Left Ventricular Assist Device: 30-Day Outcomes From the ELEVATE Registry. Ann Thorac Surg. 2019 Jan;107(1):33-39. doi: 10.1016/j.athoracsur.2018.07.092. Epub 2018 Oct 3.

Reference Type DERIVED
PMID: 30291831 (View on PubMed)

Gustafsson F, Shaw S, Lavee J, Saeed D, Pya Y, Krabatsch T, Schmitto J, Morshuis M, Chuang J, Damme L, Zimpfer D, Garbade J. Six-month outcomes after treatment of advanced heart failure with a full magnetically levitated continuous flow left ventricular assist device: report from the ELEVATE registry. Eur Heart J. 2018 Oct 1;39(37):3454-3460. doi: 10.1093/eurheartj/ehy513.

Reference Type DERIVED
PMID: 30165521 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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HeartMate 3™ Registry

Identifier Type: -

Identifier Source: org_study_id

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