Evidence of Neuroplasticity After Performing a Cognitive Task in Idiopathic Parkinson's Disease Patients
NCT ID: NCT02494908
Last Updated: 2015-07-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
80 participants
INTERVENTIONAL
2015-07-31
2018-07-31
Brief Summary
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Detailed Description
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PD patients and controls will undergo a full cranial MRI scan for depiction of anatomy and structural abnormalities (scan duration \~40 min). Immediately afterwards the subjects will play a car race computer game (Need for Speed) for 90 minutes. Following the game, the patients will undergo an additional DTI MRI scan (\~15 minutes).
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Healthy controls
Healthy controls with no known neurological disease matched for sex and age with the patients group
Playing a computer game simulating a car race
Playing a computer game simulating a car race
IPD patients
Men and women diagnosed with idiopathic parkinson's disease
Playing a computer game simulating a car race
Playing a computer game simulating a car race
Interventions
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Playing a computer game simulating a car race
Playing a computer game simulating a car race
Eligibility Criteria
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Inclusion Criteria
* Healthy subjects should have no known neurological disease matched for age and sex with the study group
Exclusion Criteria
* History of psychiatric disease (major depression, bipolar affective disorder, schizophrenia)
* Patients with severe tremor or dyskinesias that may interfere with performance of the MRI scan
* Patients with Montreal Cognitive Assessment (MoCA) score of 22 or under
* Contraindications for MRI (metal objects: implants/shrapnel/bullet; any electrically, magnetically or mechanically activated implants: cardiac pacemakers/defibrillator, biostimulators, neurostimulators, cochlear implants, hearing aids, insulin pump; claustrophobia)
* Subjects who are familiar and have played on multiple occasions the computer game "need for speed"
30 Years
80 Years
ALL
Yes
Sponsors
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Bar-Ilan University, Israel
OTHER
Tel Aviv University
OTHER
Sheba Medical Center
OTHER_GOV
Dr. Sharon Hassin
OTHER_GOV
Responsible Party
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Dr. Sharon Hassin
Dr.
Principal Investigators
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Sharon Hassin-Baer, Dr
Role: PRINCIPAL_INVESTIGATOR
Sheba Medical Center
Locations
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Movement Disorders Institute, Sheba Medical center
Ramat Gan, , Israel
Countries
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Central Contacts
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Facility Contacts
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References
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Sagi Y, Tavor I, Hofstetter S, Tzur-Moryosef S, Blumenfeld-Katzir T, Assaf Y. Learning in the fast lane: new insights into neuroplasticity. Neuron. 2012 Mar 22;73(6):1195-203. doi: 10.1016/j.neuron.2012.01.025. Epub 2012 Mar 21.
Vakil E, Herishanu-Naaman S. Declarative and procedural learning in Parkinson's disease patients having tremor or bradykinesia as the predominant symptom. Cortex. 1998 Sep;34(4):611-20. doi: 10.1016/s0010-9452(08)70518-5.
Exner C, Koschack J, Irle E. The differential role of premotor frontal cortex and basal ganglia in motor sequence learning: evidence from focal basal ganglia lesions. Learn Mem. 2002 Nov-Dec;9(6):376-86. doi: 10.1101/lm.48402.
Doyon J, Bellec P, Amsel R, Penhune V, Monchi O, Carrier J, Lehericy S, Benali H. Contributions of the basal ganglia and functionally related brain structures to motor learning. Behav Brain Res. 2009 Apr 12;199(1):61-75. doi: 10.1016/j.bbr.2008.11.012. Epub 2008 Nov 17.
Gheysen F, Van Opstal F, Roggeman C, Van Waelvelde H, Fias W. The neural basis of implicit perceptual sequence learning. Front Hum Neurosci. 2011 Nov 11;5:137. doi: 10.3389/fnhum.2011.00137. eCollection 2011.
Hofstetter S, Tavor I, Tzur Moryosef S, Assaf Y. Short-term learning induces white matter plasticity in the fornix. J Neurosci. 2013 Jul 31;33(31):12844-50. doi: 10.1523/JNEUROSCI.4520-12.2013.
Hill RA. Do short-term changes in white matter structure indicate learning-induced myelin plasticity? J Neurosci. 2013 Dec 11;33(50):19393-5. doi: 10.1523/JNEUROSCI.4122-13.2013. No abstract available.
Foerde K, Shohamy D. The role of the basal ganglia in learning and memory: insight from Parkinson's disease. Neurobiol Learn Mem. 2011 Nov;96(4):624-36. doi: 10.1016/j.nlm.2011.08.006. Epub 2011 Sep 16.
Schlaug G. Musicians and music making as a model for the study of brain plasticity. Prog Brain Res. 2015;217:37-55. doi: 10.1016/bs.pbr.2014.11.020. Epub 2015 Feb 11.
Blumenfeld-Katzir T, Pasternak O, Dagan M, Assaf Y. Diffusion MRI of structural brain plasticity induced by a learning and memory task. PLoS One. 2011;6(6):e20678. doi: 10.1371/journal.pone.0020678. Epub 2011 Jun 20.
Other Identifiers
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2372-15-SMC
Identifier Type: -
Identifier Source: org_study_id
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