Study of the Angiogenesis by PET/CT in Patients With Lymphoma

NCT ID: NCT02490891

Last Updated: 2026-01-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-11-13

Study Completion Date

2020-10-16

Brief Summary

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The aim of the study is to measure tumoral angiogenesis modifications by RGD-K5 PET/CT before and after 2 cycles of chemotherapy in patients with lymphoma and a large tumoral mass

Detailed Description

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After inclusion PET scans with FDG tracer and with a specific tracer of angiogenesis will be performed on patient with lymphoma. After two cycles of chemotherapy PET scans with the same tracers will be performed.

Overall survival and disease free survival will be monitored during 18 months.

Conditions

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Lymphoma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Study Groups

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PET scan with RGD K5 imaging

PET scan with RGD K5 tracer will be performed before and after two cycles of chemotherapy

Group Type EXPERIMENTAL

RGD K5 PET scan

Intervention Type DEVICE

PET scan with a tracer specific for angiogenesis (RGD K5) will be performed before and after 2 cycles of chemotherapy

Interventions

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RGD K5 PET scan

PET scan with a tracer specific for angiogenesis (RGD K5) will be performed before and after 2 cycles of chemotherapy

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Male or Female
* Age ≥ 18 years old
* OMS ≤ 1
* Histological diagnosis of diffuse large B-cell lymphoma what ever the subtype
* Presence of measurable tumor with at least a node mass superior to 3 centimeters
* Stage I to IV
* Inform consent signed

Exclusion Criteria

* Primary cerebral lymphoma
* Absence of fixing on FDG-PET exam
* Pregnant , child bearing, breast feeding or without effective contraception method woman
* Hypersensitivity to RGD-K5
* Hypersensitivity to FDG
* Poorly controlled diabètes (glycemia ≥ 10 millimoles/liter)
* Neoplastic disease (less than 2 years or in progression)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Henri Becquerel

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pierre Vera, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Centre Henri Becquerel

Locations

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Centre Henri Becquerel

Rouen, , France

Site Status

Countries

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France

Other Identifiers

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CHB14.02

Identifier Type: -

Identifier Source: org_study_id

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