Evaluation of Pressure Sense Threshold and Tactile Sensation After Lidocaine Iontophoresis Using Interferential Current
NCT ID: NCT02487914
Last Updated: 2015-07-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2/PHASE3
30 participants
INTERVENTIONAL
2013-01-31
2015-03-31
Brief Summary
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Detailed Description
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Lidocaine iontophoresis using interferential current can increase perception threshold of pain, and pressure sense more significantly in comparison to the application of Lidocaine and interferential current alone.
Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
TREATMENT
DOUBLE
Study Groups
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lidocaine iontophoresis using interferential current
the threshold of pressure, tactile,and pain thresholds were evaluated after the iontophoresis of Lidocaine using interferential current.
iontophoresis of Lidocaine 10% with interferential current (Dynatron 438)
drug delivery through interferential current.
interferential current
the threshold of pressure, tactile,and pain thresholds were evaluated after the application of interferential current.
interferential current
lidocaine
the threshold of pressure, tactile,and pain thresholds were evaluated after the application of topical Lidocaine.
Lidocaine 10% was sprayed at the identified region
Interventions
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iontophoresis of Lidocaine 10% with interferential current (Dynatron 438)
drug delivery through interferential current.
Lidocaine 10% was sprayed at the identified region
interferential current
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* neuro-muscular diseases such as diabetes and all forms of neuropathies,
* and use of narcoleptic drugs which may contaminate the results.
* Also, none of the participants were on their menstrual cycle.
18 Years
25 Years
FEMALE
Yes
Sponsors
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Shiraz University of Medical Sciences
OTHER
Responsible Party
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Alireza Motealleh
Dr. Amin Kordi Yoosefinejad
Principal Investigators
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alireza motealleh, PhD, PT
Role: STUDY_DIRECTOR
Shiraz University of Medical Sciences
Locations
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School of Rehabilitation
Shiraz, Fars, Iran
Countries
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References
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Baskurt F, Ozcan A, Algun C. Comparison of effects of phonophoresis and iontophoresis of naproxen in the treatment of lateral epicondylitis. Clin Rehabil. 2003 Feb;17(1):96-100. doi: 10.1191/0269215503cr588oa.
Ebrahimi S, Abbasnia K, Motealleh A, Kooroshfard N, Kamali F, Ghaffarinezhad F. Effect of lidocaine phonophoresis on sensory blockade: pulsed or continuous mode of therapeutic ultrasound? Physiotherapy. 2012 Mar;98(1):57-63. doi: 10.1016/j.physio.2011.01.009.
Gokoglu F, Findikoglu G, Yorgancoglu ZR, Okumus M, Ceceli E, Kocaoglu S. Evaluation of iontophoresis and local corticosteroid injection in the treatment of carpal tunnel syndrome. Am J Phys Med Rehabil. 2005 Feb;84(2):92-6. doi: 10.1097/01.phm.0000151942.49031.dd.
Pal B, Morris J. Perceived risks of joint infection following intra-articular corticosteroid injections: a survey of rheumatologists. Clin Rheumatol. 1999;18(3):264-5. doi: 10.1007/s100670050098.
Jadoul A, Bouwstra J, Preat V V. Effects of iontophoresis and electroporation on the stratum corneum. Review of the biophysical studies. Adv Drug Deliv Rev. 1999 Jan 4;35(1):89-105. doi: 10.1016/s0169-409x(98)00065-9.
Jadoul A, Doucet J, Durand D, Preat V. Modifications induced on stratum corneum structure after in vitro iontophoresis; ATR-FTIR and X-ray scattering studies. J. Controlled Release 42: 165-173,1996.
Thysman S, Van Neste D, Preat V. Noninvasive investigation of human skin after in vivo iontophoresis. Skin Pharmacol. 1995;8(5):229-36. doi: 10.1159/000211352.
Costello CT, Jeske AH. Iontophoresis: applications in transdermal medication delivery. Phys Ther. 1995 Jun;75(6):554-63. doi: 10.1093/ptj/75.6.554.
Singh P, Maibach HI. Iontophoresis in drug delivery: basic principles and applications. Crit Rev Ther Drug Carrier Syst. 1994;11(2-3):161-213.
Panzade P, Puranik P. Iontophoresis: A Functional Approach for Enhancement of Transdermal Drug Delivery. Asian Journal of Biomedical and Pharmaceutical Sciences 2(11): 1-8, 2012.
Banga AK, Chien YW. Hydrogel-based iontotherapeutic delivery devices for transdermal delivery of peptide/protein drugs. Pharm Res. 1993 May;10(5):697-702. doi: 10.1023/a:1018955631835.
Gupta SK, Bernstein KJ, Noorduin H, Van Peer A, Sathyan G, Haak R. Fentanyl delivery from an electrotransport system: delivery is a function of total current, not duration of current. J Clin Pharmacol. 1998 Oct;38(10):951-8. doi: 10.1002/j.1552-4604.1998.tb04392.x.
Lvovich VF, Matthews E, Riga AT, Kaza L. AC electrokinetic platform for iontophoretic transdermal drug delivery. J Control Release. 2010 Jul 14;145(2):134-40. doi: 10.1016/j.jconrel.2010.04.015. Epub 2010 Apr 24.
Reinauer S, Neusser A, Schauf G, Holzle E. Iontophoresis with alternating current and direct current offset (AC/DC iontophoresis): a new approach for the treatment of hyperhidrosis. Br J Dermatol. 1993 Aug;129(2):166-9. doi: 10.1111/j.1365-2133.1993.tb03521.x.
Ganne JM. Interferential therapy. Aust J Physiother. 1976 Sep;22(3):101-10. doi: 10.1016/S0004-9514(14)61005-9.
Jorge S, Parada CA, Ferreira SH, Tambeli CH. Interferential therapy produces antinociception during application in various models of inflammatory pain. Phys Ther. 2006 Jun;86(6):800-8.
Watson T. The role of electrotherapy in contemporary physiotherapy practice. Man Ther. 2000 Aug;5(3):132-41. doi: 10.1054/math.2000.0363.
Bhatia G, Banga AK. Effect of modulated alternating and direct current iontophoresis on transdermal delivery of lidocaine hydrochloride. Biomed Res Int. 2014;2014:537941. doi: 10.1155/2014/537941. Epub 2014 May 15.
Hayashi S, Ogami S, Shibaji T, Umino M. Lidocaine transport through a cellophane membrane by alternating current iontophoresis with a duty cycle. Bioelectrochemistry. 2009 Feb;74(2):315-22. doi: 10.1016/j.bioelechem.2008.11.007. Epub 2008 Nov 30.
Yan G, Xu Q, Anissimov YG, Hao J, Higuchi WI, Li SK. Alternating current (AC) iontophoretic transport across human epidermal membrane: effects of AC frequency and amplitude. Pharm Res. 2008 Mar;25(3):616-24. doi: 10.1007/s11095-007-9405-2. Epub 2007 Aug 17.
Yamazaki Y, Umino M, Fukayama H, Shimada M. The effect of alternating current iontophoresis on rats with the chronic constriction injury to the infraorbital nerve. Int J Dent. 2012;2012:405292. doi: 10.1155/2012/405292. Epub 2012 May 23.
Kandell ER, Schwartz JH, Jessell TM. Principles of neural science 2000. 4th edition.
Viscusi ER, Witkowski TA. Iontophoresis: the process behind noninvasive drug delivery. Reg Anesth Pain Med. 2005 May-Jun;30(3):292-4. doi: 10.1016/j.rapm.2004.12.002. No abstract available.
Other Identifiers
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386
Identifier Type: -
Identifier Source: org_study_id
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