Exercise and Body Composition in Juvenile Idiopathic Arthritis
NCT ID: NCT02479373
Last Updated: 2018-04-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
33 participants
INTERVENTIONAL
2012-07-31
2015-10-31
Brief Summary
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JIA is an inflammatory autoimmune disease that can cause severe impairment and disability. JIA can cause bone loss and decreased muscle strength. The medications used to treat JIA can also have negative effects on growth and development, strength, and ability to function. RE is performing movements in a slow and controlled fashion (i.e., no speeding up or using force in the lifting and lowering of the weight) to lessen force on the joints and tissues. This study will be using Ren-Ex exercise equipment to perform RE.
Currently the American College of Rheumatology recommends exercise for patients with arthritis. This exercise includes range of motion exercise to protect joint mobility as well as low resistance and aerobic exercise (AE) to protect muscle mass, bone health, and fitness. However, a recent study showed no major differences in functionality or quality of life between patients who performed AE and those who did not perform AE. There is a need for more data on the impact of RE on children with JIA. Children and young adults aged 10 to 21 with juvenile idiopathic arthritis may join.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
Study Groups
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Resistance Exercise (RE)
Those assigned to RE will complete baseline and post-testing assessments and participate in 12 weeks of individually-supervised resistance exercise, which will take place in the exercise facility on the Johns Hopkins Bayview Medical Center Campus. Exercises will be performed on Ren-Ex Machines. This equipment is suitable for the proposed study because it provides ultra-low friction movement which creates a personalized resistance profile, which minimizes force on joints and thereby reduces the risk of joint trauma and injury.
Ren-Ex Machine
The exercise is performed once per week with individualized instruction using moderate resistance on Ren-Ex Machines, ultra-low-friction equipment to minimize force on joints.
Dual-Emission X-ray Absorptiometry (DEXA) scan
To study body composition
Biodex dynamometer
To study muscle strength
Sub-maximal test
To study lung capacity, a sub-maximal (limited exercise) test on a stationary bicycle is performed.
Quality of life questionnaires
Control Group (CG)
Those assigned to the CG will complete baseline and post-testing assessments and will also be given JIA educational materials, including physical activity and exercise recommendations from the American Academy of Pediatrics (AAP) Council on Sports Medicine and Fitness (COSMF).
Dual-Emission X-ray Absorptiometry (DEXA) scan
To study body composition
Biodex dynamometer
To study muscle strength
Sub-maximal test
To study lung capacity, a sub-maximal (limited exercise) test on a stationary bicycle is performed.
Quality of life questionnaires
Interventions
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Ren-Ex Machine
The exercise is performed once per week with individualized instruction using moderate resistance on Ren-Ex Machines, ultra-low-friction equipment to minimize force on joints.
Dual-Emission X-ray Absorptiometry (DEXA) scan
To study body composition
Biodex dynamometer
To study muscle strength
Sub-maximal test
To study lung capacity, a sub-maximal (limited exercise) test on a stationary bicycle is performed.
Quality of life questionnaires
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Stable medical therapy
Exclusion Criteria
* Pregnancy
* Currently breast feeding
* Cognitive impairment as determined by PI (patient is not responsible for making their own health care decisions)
10 Years
21 Years
ALL
No
Sponsors
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National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Johns Hopkins University
OTHER
Responsible Party
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Principal Investigators
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Sangeeta Sule, M.D., Ph.D.
Role: PRINCIPAL_INVESTIGATOR
Johns Hopkins University
Locations
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Johns Hopkins University
Baltimore, Maryland, United States
Countries
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Other Identifiers
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NA00071505
Identifier Type: -
Identifier Source: org_study_id
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