Effect of a Monthly High Dose of Vitamin D3 on Bariatric Surgery Patients

NCT ID: NCT02477956

Last Updated: 2015-06-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

31 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-11-30

Study Completion Date

2013-12-31

Brief Summary

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Bariatric surgery patients tend to have malabsorption of many micronutrients such as B12, Iron and vitamin D postoperative. So in this study, a monthly high dose of vitamin D3 is giving to patients with their routine supplements and followed up for 6 months.

Hypothesis:Bariatric surgery subjects taking monthly high dose cholecalciferol supplements in addition to the standard vitamin D protocol will have a significant rise in serum vitamin D levels compared to the subjects taking only the usual vitamin D protocol.

Detailed Description

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Sun exposure and supplement use questionnaire:

A registered dietitian asked each subject for information on sun exposure, vitamins, medications, and any other supplement usage before each blood sample was taken.

Lab analysis included serum hydroxy vitamin D levels pre and 3 months postoperative.

Descriptive statistics which include both the means and standard deviations were calculated on the study variables. A paired sample t-test was used to determine if there was a significant difference in mean values pre and post vitamin D supplementation. An independent sample t-test was used to assess for significant differences in group (control vs. vitamin D supplement) means. A p-value \< 0.05 was considered statistically significant. Statistical analyses were done using SPSS Version 21 (SPSS, Chicago, III, USA).

Conditions

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Morbid Obesity Vitamin D Deficiency

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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vitamin D3

subjects taking the standard vitamin D protocol with added monthly high dose cholecalciferol of 100,000 IU cholecalciferol

Group Type EXPERIMENTAL

vitamin D3 (Replesta)

Intervention Type DIETARY_SUPPLEMENT

vitamin D group receive 2 replesta tablets (100,000 IU/month) of cholecalciferol.

Control

group of subjects taking the standard vitamin D

Group Type ACTIVE_COMPARATOR

vitamin D

Intervention Type DIETARY_SUPPLEMENT

Interventions

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vitamin D3 (Replesta)

vitamin D group receive 2 replesta tablets (100,000 IU/month) of cholecalciferol.

Intervention Type DIETARY_SUPPLEMENT

vitamin D

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Replesta

Eligibility Criteria

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Inclusion Criteria

* morbidly obese and eligible for bariatric surgery

Exclusion Criteria

* under 18 and over 60 years of age
* elevated serum vitamin D and calcium
* pregnant and lactating women
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Texas Tech University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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David Syn, MD

Role: PRINCIPAL_INVESTIGATOR

Texas Tech University Health Sciences Center

Mallory Boylan, PhD

Role: STUDY_DIRECTOR

Texas Tech University

Hadil Subih, PhD

Role: STUDY_CHAIR

Texas Tech University

Shannon Owens, PhD

Role: STUDY_CHAIR

Texas Tech University

Locations

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Texas Tech University

Lubbock, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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Highly dose of vitamin D3

Identifier Type: -

Identifier Source: org_study_id

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