Study to Assess the Relative Potency of Multiple Oral Doses of LUM001 and SHP626 in Overweight and Obese Adults as Assessed by Fecal Bile Acid Excretion

NCT ID: NCT02475317

Last Updated: 2019-04-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 84 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-06-01
• Study Completion Date: 2015-12-01

Brief Summary

The purpose of this study is to assess the relative potency of multiple oral doses of LUM001 and SHP626 administered for 7 days as assessed by fecal bile acid excretion in overweight and obese adult subjects. This study is designed to address the relative potency question for the first time in the same.

Conditions

Healthy Volunteers

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: DOUBLE

Study Groups

Placebo

Participants will receive placebo matched to maralixibat 10 milligram (mg), 20 mg, 50 mg once daily (QD), 50 mg twice daily (BID), 100 mg liquid formulation and volixibat 10 mg, 20 mg capsule orally for 7 days.

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

Participants will receive placebo matched to maralixibat/volixibat orally for 7 days.

Maralixibat 10mg

Participants will receive maralixibat 10 mg liquid formulation orally QD for 7 days.

Group Type: EXPERIMENTAL

Maralixibat

Intervention Type: DRUG

Participants will receive maralixibat in 10 mg, 20 mg, 50 mg or 100 mg doses.

Volixibat 10mg

Participants will receive volixibat 10 mg capsule orally QD for 7 days.

Group Type: EXPERIMENTAL

Volixibat

Intervention Type: DRUG

Participants will receive volixibat in 10 mg and 20 mg doses.

Maralixibat 20mg

Participants will receive maralixibat 20 mg liquid formulation orally QD for 7 days.

Group Type: EXPERIMENTAL

Maralixibat

Intervention Type: DRUG

Participants will receive maralixibat in 10 mg, 20 mg, 50 mg or 100 mg doses.

Volixibat 20mg

Participants will receive volixibat 20 mg capsule orally QD for 7 days.

Group Type: EXPERIMENTAL

Volixibat

Intervention Type: DRUG

Participants will receive volixibat in 10 mg and 20 mg doses.

Maralixibat 50mg

Participants will receive maralixibat 50 mg liquid formulation orally QD for 7 days.

Group Type: EXPERIMENTAL

Maralixibat

Intervention Type: DRUG

Participants will receive maralixibat in 10 mg, 20 mg, 50 mg or 100 mg doses.

Maralixibat 50mg BID

Participants will receive maralixibat 50 mg liquid formulation orally BID for 7 days.

Group Type: EXPERIMENTAL

Maralixibat

Intervention Type: DRUG

Participants will receive maralixibat in 10 mg, 20 mg, 50 mg or 100 mg doses.

Maralixibat 100mg

Participants will receive maralixibat 100 mg liquid formulation orally QD for 7 days.

Group Type: EXPERIMENTAL

Maralixibat

Intervention Type: DRUG

Participants will receive maralixibat in 10 mg, 20 mg, 50 mg or 100 mg doses.

Interventions

Placebo

Participants will receive placebo matched to maralixibat/volixibat orally for 7 days.

Intervention Type: DRUG

Maralixibat

Participants will receive maralixibat in 10 mg, 20 mg, 50 mg or 100 mg doses.

Intervention Type: DRUG

Volixibat

Participants will receive volixibat in 10 mg and 20 mg doses.

Intervention Type: DRUG

Other Intervention Names

LUM001; SHP626

Eligibility Criteria

Inclusion Criteria

1. An understanding, ability, and willingness to fully comply with study procedures, study diet, and restrictions.

2. Ability to voluntarily provide written, signed, and dated (personally or via a legally-authorized representative) informed consent/and assent as applicable to participate in the study.

3. Aged 18-65 years inclusive at the time of consent. The date of signature of the informed consent is defined as the beginning of the screening period. This inclusion criterion will only be assessed at the first screening visit.

4. Males who agree to comply with any applicable contraceptive requirements of the protocol or females of non-childbearing potential (see Section 4.4 for details).

5. Must be considered generally healthy. Health status is defined by the absence of evidence of any active or chronic disease (see Section 7.2.2.1 for details and exceptions) following the completion of a detailed medical and surgical history, a complete physical examination, vital signs, 12-lead ECG, hematology, blood chemistry, and urinalysis.

6. Must have a body mass index of 25.0-35.0 kg/m² inclusive with a body weight >63.5 kg (140 lbs at the first screening visit). This inclusion criterion will only be assessed at the first screening visit.

7. All clinical laboratory parameters are within normal laboratory limit or not found to be clinically significant by the principal investigator.

8. Ability to swallow a dose(s) of investigational product(s).

Exclusion Criteria

1. History of any hematological, hepatic, respiratory, cardiovascular, renal, neurological, or psychiatric disease, gall bladder removal, or current or recurrent disease that could affect the action, absorption, or disposition of the investigational product, or clinical or laboratory assessments.

2. Current or relevant history of physical or psychiatric illness, any medical disorder that may require treatment or make the subject unlikely to fully complete the study, or any condition that presents undue risk from the investigational product or procedures.

3. Known or suspected intolerance or hypersensitivity to the investigational product(s), closely-related compounds, or any of the stated ingredients.

4. Significant illness, as judged by the investigator, within 2 weeks prior to the first dose of investigational product.

5. Known history of alcohol or other substance abuse within the last year.

6. Donation of blood or blood products (eg, plasma or platelets) within 60 days prior to receiving the first dose of investigational product.

7. Within 30 days prior to the first dose of investigational product:

• Have used an investigational product (if elimination half-life is <6 days, otherwise 5 half-lives).
• Have been enrolled in a clinical study (including vaccine studies) that, in the investigator's opinion, may impact this Shire-sponsored study.
• Have had any substantial changes in eating habits or exercise routine, as assessed by the investigator

8. Confirmed resting systolic blood pressure >145 mmHg or <89 mmHg, and diastolic blood pressure >95 mmHg or <59 mmHg.

9. Twelve-lead ECG demonstrating QTc >460 milliseconds for male subjects or >470 milliseconds for female subjects at screening. If QTc exceeds 460 milliseconds for males or 470 milliseconds for females, the ECG should be repeated 2 more times and the average of the 3 QTc values should be used to determine the subject's eligibility

10. A positive screen for drugs of abuse at screening or at Day -3 (check-in).

11. Male subjects who consume more than 21 units of alcohol per week or 3 units per day. Female subjects who consume more than 14 units of alcohol per week or 2 units per day. (1 alcohol unit=1 beer or 1 wine [5 oz/150 mL] or 1 liquor [1.5 oz/40 mL] or 0.75 oz alcohol).

12. A positive HIV, hepatitis B surface antigen (HBsAg), or hepatitis C virus (HCV) antibody screen.

13. Use of tobacco (eg, smoking or chewing) or other nicotine-containing products (eg, gum, patch) in any form. Ex-users must report that they have stopped using tobacco for at least 30 days prior to receiving the first dose of investigational product.

14. Routine consumption of more than 2 units of caffeine per day or subjects who experience caffeine withdrawal headaches. (One caffeine unit is contained in the following items: one 6 oz [180 mL] cup of coffee, two 12 oz [360 mL] cans of cola, one 12 oz cup of tea, and three 1 oz [85 g] chocolate bars. Decaffeinated coffee, tea, and cola are not considered to contain caffeine.)

15. Prior screen failure, randomization, participation, or enrollment in this study. If a subject has successfully completed a study using LUM001 or SHP626, they may participate in this study providing at least 30 days has passed since their last dose of these investigational products and they have successfully completed all screening procedures

16. Current use of any medication (including over-the-counter, herbal, or homeopathic preparations) with the exception of those medications listed in Section 5.2.1. (Current use is defined as use within 14 days of the first dose of investigational product.)

17. An inability to follow a standardized diet and meal schedule or inability to fast, as required during the study.

18. Colonoscopy, barium enema, or other tests that require a bowel cleansing within 4 weeks prior to the first dose of investigational product.

19. Subjects who report typically having less than 3 bowel movements per week or greater than 3 bowel movements per day.

20. Use of antibiotics within 30 days prior to the first dose of investigational product.

21. Use of bile acid sequestrants within 30 days prior to the first dose of investigational product

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Mirum Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Study Director

Role: STUDY_DIRECTOR

Mirum

Locations

New Orleans Center for Clinical Research

Knoxville, Tennessee, United States

Countries

United States

Other Identifiers

SHP625-101

Identifier Type: -

Identifier Source: org_study_id