The Blood Saving Effect of Tranexamic Acid in Total Knee Arthroplasty With Rivaroxaban as Thromboprophylaxis

NCT ID: NCT02458729

Last Updated: 2015-06-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

294 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-08-31

Study Completion Date

2014-07-31

Brief Summary

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The aim of this study was to conduct a prospective, randomized, double-blind study and assess the efficacy of and safety for thromboprophylaxis of rivaroxaban in total knee arthroplasty patients when tranexamic acid is used for bleeding prophylaxis.

Detailed Description

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Total knee arthroplasty is an effective procedure for end-stage arthritis of the knee in terms of pain relief and functional recovery. However, this procedure is associated with a substantial perioperative blood loss. As high as 69% allogeneic blood transfusion rate was reported in patients receiving total knee arthroplasty when preoperative haemoglabin level was \<13 g/dl. Tranexamic acid (TXA), an antifibrinolytic, given intraoperatively, has been reported to be effective in reducing one third of postoperative blood loss in standard total knee arthroplasty. Our previous study showed that TXA reduced total blood loss from 1453mL to 833mL (p\<0.001) and the need for transfusion from 20% to 4% (p=0.014) in total knee patients with enoxaparin (Clexane; Glaxo-Smith-Kline, Brentford, United Kindom) for thromboprophylaxis.

In recent years, there have been more effective and practical methods for thrombophylaxis in total hip and knee replacement surgeries. Rivaroxaban is one of the first oral factor Xa inhibitors licensed for this regard. The advantages of rivaroxaban include oral administration, no need to monitor blood levels and no dosing adjustments which are convenient for short hospital stay in contemporary total knee arthroplasty. Its efficacy in preventing venous thromboembolism (VTE) after total knee arthroplasty have been extensitvely investigated in RECORD (Regulation of Coagulation in Orthopaedic surgery to prevent Deep-vein thrombosis and pulmonary embolism) 3 and 4 studies, and the results showed that rivaroxaban 10mg once daily was superior to enoxaparin 40mg subcutaneously once daily or 30mg every 12 hours for 10 to 14 days. Despite of its clinical efficacy in VTE prophylaxis, orthopaedic surgeons are still sceptic in routine use of rivaroxaban in knee and hip surgery and concerned about the increased risk of bleeding complications. A higher reoperation rate regarding wound complications within 30 days of hip and knee replacement in the rivaroxaban group than the tinzaparin group (2.94% versus 1.8%) was reported recently. Similar event has been reported in other studies. However, all these studies did not use TXA as bleeding prophylaxis after hip and knee replacement surgery. The risk of increasing VTE by use of TXA, owing to its antifibrinolytic effects, is the cause of concern.

The aim of this study was to conduct a prospective, randomized, double-blind study and assess the efficacy of and safety for thromboprophylaxis of rivaroxaban in total knee arthroplasty patients when TXA is used for bleeding prophylaxis.

Conditions

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Osteoarthritis, Knee

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo Group

Primary total knee replacement with 0.9% normal saline 20ml administration intravenously twice, five minutes before deflation of the tourniquet and 3 hours after operation Oral rivaroxaban (10mg) QD on PostOp Day 1 to 14 for VTE prophylaxis

Group Type PLACEBO_COMPARATOR

0.9% Normal Saline (intraoperative)

Intervention Type DRUG

0.9% Normal Saline 20ml administered intravenously five minutes before deflation of the tourniquet

0.9% Normal Saline (3 hours after operation)

Intervention Type DRUG

0.9% Normal Saline 20ml administered intravenously 3 hours after operation

rivaroxaban (10mg)

Intervention Type DRUG

Oral rivaroxabam (10mg) QD on PostOp Day 1 to 14

One-dose TXA Group

Primary total knee replacement with 1 g Tranexamic Acid 5%,5ml/amp administrated intravenously five minutes before deflation of the tourniquet. and then 0.9% normal saline 20ml administration intravenously 3 hours after operation Oral rivaroxaban (10mg) QD on PostOp Day 1 to 14 for VTE prophylaxis

Group Type ACTIVE_COMPARATOR

Tranexamic Acid 5%,5ml/amp (intraoperative)

Intervention Type DRUG

tranexamic acid 1g administered intravenously five minutes before deflation of the tourniquet

0.9% Normal Saline (3 hours after operation)

Intervention Type DRUG

0.9% Normal Saline 20ml administered intravenously 3 hours after operation

rivaroxaban (10mg)

Intervention Type DRUG

Oral rivaroxabam (10mg) QD on PostOp Day 1 to 14

Two-dose TXA Group

Primary total knee replacement with 1 g Tranexamic Acid 5%,5ml/amp administrated intravenously twice, five minutes before deflation of the tourniquet and 3 hours after operation Oral rivaroxaban (10mg) QD on PostOp Day 1 to 14 for VTE prophylaxis

Group Type ACTIVE_COMPARATOR

Tranexamic Acid 5%,5ml/amp (intraoperative)

Intervention Type DRUG

tranexamic acid 1g administered intravenously five minutes before deflation of the tourniquet

Tranexamic Acid 5%,5ml/amp (3 hours after operation)

Intervention Type DRUG

tranexamic acid 1g administered intravenously 3 hours after operation

rivaroxaban (10mg)

Intervention Type DRUG

Oral rivaroxabam (10mg) QD on PostOp Day 1 to 14

Interventions

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Tranexamic Acid 5%,5ml/amp (intraoperative)

tranexamic acid 1g administered intravenously five minutes before deflation of the tourniquet

Intervention Type DRUG

Tranexamic Acid 5%,5ml/amp (3 hours after operation)

tranexamic acid 1g administered intravenously 3 hours after operation

Intervention Type DRUG

0.9% Normal Saline (intraoperative)

0.9% Normal Saline 20ml administered intravenously five minutes before deflation of the tourniquet

Intervention Type DRUG

0.9% Normal Saline (3 hours after operation)

0.9% Normal Saline 20ml administered intravenously 3 hours after operation

Intervention Type DRUG

rivaroxaban (10mg)

Oral rivaroxabam (10mg) QD on PostOp Day 1 to 14

Intervention Type DRUG

Other Intervention Names

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Transamine Transamine 0.9% sodium chloride 0.9% Normal Saline Xarelto

Eligibility Criteria

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Inclusion Criteria

* End-stage arthritis of the knee
* Failure of medical treatment or rehabilitation
* Hemoglobin \> 10g/dl
* No use of non-steroid anti-inflammatory agent one week before operation

Exclusion Criteria

* Preoperative Hemoglobin ≦10 g/dl
* History of infection or intraarticular fracture of the affective knee
* Renal function deficiency (GFR \< 55 ml/min/1.73m2)which is relative contraindicated for venography
* Elevated liver enzyme, history of liver cirrhosis, impaired liver function and coagulopathy (including long-term use anticoagulant)
* History of deep vein thrombosis, ischemic heart disease or stroke
Minimum Eligible Age

50 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chang Gung Memorial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Wang Jun-Wen

Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jun-Wen Wang, MD

Role: STUDY_CHAIR

Chang Gung Memorial Hospital

Locations

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Kaohsiung Chang Gung Memorial Hospital

Koahsiung, Taiwan, Taiwan

Site Status

Countries

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Taiwan

References

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Other Identifiers

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NMRPG8B6181

Identifier Type: -

Identifier Source: org_study_id

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