Review of Human Herpes Viruses in Burns

NCT ID: NCT02452229

Last Updated: 2015-05-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

10267 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-03-31

Brief Summary

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Herpes simplex virus, cytomegalovirus and varicella zoster virus infection are purported to play a pivotal role in morbidity and mortality in burns. Thus far, there is no existing systematic review (Level of Evidence III or higher) describing the unique role as well as concurrent infections of these viruses in burns. The aim of this review is to point out the clinical differences between these human herpes virus subtypes, to outline established therapy approaches, and to provide evidence for virus related morbidity and mortality in burns.

Detailed Description

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This systematic review was created according the PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist.

We performed an review of the medical literature to identify all studies that contain HSV, CMV and VZV infections in burns.Therefore, systematic review of the Medline database by using PubMed and Ovid interface was conducted. Also the Web of Science interface was used for systematic literature search.

On the PubMed interface, we used the following search terms: ("HSV"\[All Fields\] OR "herpes"\[All Fields\] OR "CMV"\[All Fields\] OR "cytomegalovirus"\[All Fields\] OR "VZV"\[All Fields\] OR "varicella-zoster"\[All Fields\]) AND ("burns"\[MeSH Terms\] OR "burns"\[All Fields\] OR "burn"\[All Fields\] OR "thermal trauma"\[All Fields\]). For Ovid we used: exp Burns/ AND (exp Herpes Zoster/ or exp Encephalitis, Herpes Simplex/ or exp Herpes Simplex/ or exp Herpes Simples Virus Vaccines/), exp Burns/ AND (exp Cytomegalovirus/ or exp Cytomegalovirus Infections/), exp Burns/ AND (exp Chickenpox/ or Herpesvirus 3. Human/ or exp Herpes Zoster/). And for Web of Science we used: (TS=(HSV OR herpes OR CMV OR cytomegalovirus OR VZV OR varicella-zoster) AND TS=(burn OR burns OR thermal trauma)) AND LANGUAGE: (English) AND DOCUMENT TYPES: (Article); Timespan: All years; Indexes: SCI-EXPANDED, SSCI, A\&HCI, CPCI-S.

Conditions

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Human Herpes Virus Herpes Simplex Virus Varicella-zoster Virus Chickenpox Cytomegalovirus Burns

Study Design

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Study Time Perspective

RETROSPECTIVE

Study Groups

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Burn patients

The included patient are burn victims who sustained a burn of at least 1 % total body surface are (TBSA); with no restriction on age.

Review of the Literature for Human Herpes Virus infections

Intervention Type OTHER

Review of the Medline database (PubMed and Ovid interface) for human herpes virus infections in burns as well as Web of Science interface.

PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist were used.

Interventions

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Review of the Literature for Human Herpes Virus infections

Review of the Medline database (PubMed and Ovid interface) for human herpes virus infections in burns as well as Web of Science interface.

PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist were used.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients who presented with at least 1% TBSA burned
* Patients who presented with a viral infections during their hospitalization

Exclusion Criteria

* Patients who had no burns
* Patients who had no viral infections during their hospitalization
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shriners Hospitals for Children

OTHER

Sponsor Role collaborator

The University of Texas Medical Branch, Galveston

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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David N Herndon, MD, FACS

Role: STUDY_CHAIR

Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas, USA

References

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Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010;8(5):336-41. doi: 10.1016/j.ijsu.2010.02.007. Epub 2010 Feb 18. No abstract available.

Reference Type BACKGROUND
PMID: 20171303 (View on PubMed)

Other Identifiers

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SHC-G-SR-HHV

Identifier Type: -

Identifier Source: org_study_id

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